Detailed information of TA system TA036546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 580031..580553
• Replicon: chromosome
• Accession: NZ_AP022821
• Organism: Halomonas meridiana strain Slthf1

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A2M9TBV7
• Locus tag: HMSLTHF_RS02895
• Protein ID: WP_058578261.1
• Coordinates: 580031..580294 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: HMSLTHF_RS02900
• Protein ID: WP_137094295.1
• Coordinates: 580284..580553 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMSLTHF_RS02870	575316..575918	+	603	Protein_552	MBL fold metallo-hydrolase	-
HMSLTHF_RS02875	575948..577199	-	1252	Protein_553	IS256 family transposase	-
HMSLTHF_RS02880	577306..577668	+	363	Protein_554	MBL fold metallo-hydrolase	-
HMSLTHF_RS02885	577855..579020	+	1166	WP_172415915.1	IS3 family transposase	-
HMSLTHF_RS02890	579254..579955	+	702	WP_137094293.1	aspartate/glutamate racemase family protein	-
HMSLTHF_RS02895	580031..580294	+	264	WP_058578261.1	BrnT family toxin	Toxin
HMSLTHF_RS02900	580284..580553	+	270	WP_137094295.1	CopG family transcriptional regulator	Antitoxin
HMSLTHF_RS02905	580586..581032	-	447	Protein_559	homoserine acetyltransferase	-
HMSLTHF_RS02910	581029..582201	-	1173	WP_058578263.1	UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase	-
HMSLTHF_RS02915	582298..583164	+	867	WP_044628895.1	NAD-dependent protein deacetylase	-
HMSLTHF_RS02920	583306..584784	+	1479	WP_044628894.1	YdiU family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (6-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10314.77 Da
• Isoelectric Point: 7.2035

>T36546 WP_058578261.1 NZ_AP022821:580031-580294 [Halomonas meridiana]
MNEFEFDVNKSQANLTKHGIDFEAAQALWKDPYLLEIRAKSEGEPRFLLIGMISEKHWSAVVTYREERIRLISVRRSRKK
EVDIYES

Nucleotide

• Length: 264 bp

>T36546 NZ_AP022821:580031-580294 [Halomonas meridiana]
ATGAACGAGTTCGAGTTTGACGTCAACAAAAGTCAGGCCAACCTGACAAAGCACGGTATTGATTTTGAAGCGGCACAAGC
GCTGTGGAAGGATCCATATCTGCTAGAAATTCGCGCAAAATCCGAGGGCGAACCAAGGTTTTTGCTAATCGGTATGATCA
GTGAAAAACATTGGTCGGCAGTCGTCACCTACCGAGAAGAGCGTATTCGGCTGATTTCTGTTAGACGCTCCCGCAAGAAG
GAGGTAGACATCTATGAAAGCTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10301.57 Da
• Isoelectric Point: 6.8810

>AT36546 WP_137094295.1 NZ_AP022821:580284-580553 [Halomonas meridiana]
MKAKEFDKKFDENQYDVLDDLDFSTARRVNQEQKRINVDFPAWVVESLDREAARMGVTRQSIIKVWLVERLQAEAAHKPH
GHNSVGGPH

Nucleotide

• Length: 270 bp

>AT36546 NZ_AP022821:580284-580553 [Halomonas meridiana]
ATGAAAGCTAAAGAGTTCGATAAAAAATTCGATGAAAATCAATATGATGTTCTCGATGATCTAGACTTTTCCACTGCTCG
ACGGGTGAATCAGGAGCAAAAGCGGATTAACGTAGATTTTCCTGCATGGGTAGTGGAGTCACTAGACCGTGAGGCTGCGA
GAATGGGTGTTACCCGCCAGTCGATTATCAAGGTTTGGTTAGTGGAGCGTCTGCAAGCTGAAGCGGCTCATAAACCTCAT
GGCCATAACTCAGTAGGGGGACCTCACTAG

Structures

Toxin

• AlphaFold DB: A0A2M9TBV7