Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4370216..4371051 Replicon chromosome
Accession NZ_AP022815
Organism Escherichia coli strain JE86-ST05

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3K4KCT6
Locus tag JL003_RS21535 Protein ID WP_000854827.1
Coordinates 4370674..4371051 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1Y2XNS0
Locus tag JL003_RS21530 Protein ID WP_001403016.1
Coordinates 4370216..4370584 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL003_RS21490 4366301..4366756 + 456 WP_200974080.1 hypothetical protein -
JL003_RS21495 4366831..4367064 + 234 WP_001119729.1 DUF905 family protein -
JL003_RS21500 4367164..4367985 + 822 WP_032266500.1 DUF945 domain-containing protein -
JL003_RS21505 4368248..4368721 + 474 WP_000855084.1 antirestriction protein -
JL003_RS21510 4368737..4369213 + 477 WP_001186743.1 RadC family protein -
JL003_RS21515 4369282..4369503 + 222 WP_001220314.1 DUF987 domain-containing protein -
JL003_RS21520 4369522..4369743 + 222 WP_000086676.1 hypothetical protein -
JL003_RS21525 4369873..4370166 + 294 Protein_4207 antitoxin of the YeeV-YeeU toxin-antitoxin system -
JL003_RS21530 4370216..4370584 + 369 WP_001403016.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JL003_RS21535 4370674..4371051 + 378 WP_000854827.1 type IV toxin-antitoxin system toxin CbtA Toxin
JL003_RS21540 4371048..4371536 + 489 WP_000761674.1 hypothetical protein -
JL003_RS21545 4371548..4371745 + 198 WP_000839236.1 DUF957 domain-containing protein -
JL003_RS21550 4371830..4372675 + 846 WP_096855538.1 DUF4942 domain-containing protein -
JL003_RS21555 4373467..4374651 + 1185 WP_001172876.1 sugar efflux transporter -
JL003_RS21560 4374762..4375685 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14045.05 Da        Isoelectric Point: 7.8840

>T36537 WP_000854827.1 NZ_AP022815:4370674-4371051 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQILLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKR

Download         Length: 378 bp

>T36537 NZ_AP022815:4370674-4371051 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGTCGGCCAGTTCACGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGGC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCAGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13648.33 Da        Isoelectric Point: 5.9582

>AT36537 WP_001403016.1 NZ_AP022815:4370216-4370584 [Escherichia coli]
VSDTLPETNNPNDNHDRPWWGLPCTATPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT36537 NZ_AP022815:4370216-4370584 [Escherichia coli]
GTGTCAGACACGCTCCCTGAGACAAATAACCCCAACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGCGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGGCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K4KCT6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y2XNS0

References