Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2540065..2540833 Replicon chromosome
Accession NZ_AP022815
Organism Escherichia coli strain JE86-ST05

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JL003_RS12875 Protein ID WP_000854814.1
Coordinates 2540459..2540833 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3W4SUB1
Locus tag JL003_RS12870 Protein ID WP_044863316.1
Coordinates 2540065..2540370 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JL003_RS12840 2536906..2537361 + 456 WP_000581504.1 hypothetical protein -
JL003_RS12845 2537440..2537673 + 234 WP_032173243.1 DUF905 family protein -
JL003_RS12850 2537773..2538591 + 819 WP_137519561.1 DUF945 domain-containing protein -
JL003_RS12855 2538673..2539152 + 480 WP_137519560.1 antirestriction protein -
JL003_RS12860 2539168..2539644 + 477 WP_001186726.1 RadC family protein -
JL003_RS12865 2539707..2539928 + 222 WP_000692323.1 DUF987 domain-containing protein -
JL003_RS12870 2540065..2540370 + 306 WP_044863316.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JL003_RS12875 2540459..2540833 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JL003_RS12880 2540830..2541024 + 195 WP_000988600.1 hypothetical protein -
JL003_RS12885 2541037..2541150 + 114 WP_001161660.1 DUF957 domain-containing protein -
JL003_RS12890 2541439..2541612 - 174 WP_071592185.1 transposase domain-containing protein -
JL003_RS12895 2541639..2541821 + 183 WP_001016348.1 hypothetical protein -
JL003_RS12900 2541922..2542251 - 330 WP_000450409.1 DUF496 family protein -
JL003_RS12905 2542423..2542941 - 519 Protein_2522 hypothetical protein -
JL003_RS12910 2543036..2544016 - 981 WP_000399648.1 IS110-like element IS621 family transposase -
JL003_RS12915 2544080..2544760 - 681 WP_001200880.1 FUSC family protein -
JL003_RS12920 2544958..2545431 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2543036..2544016 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T36530 WP_000854814.1 NZ_AP022815:2540459-2540833 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T36530 NZ_AP022815:2540459-2540833 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11250.00 Da        Isoelectric Point: 7.2621

>AT36530 WP_044863316.1 NZ_AP022815:2540065-2540370 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT36530 NZ_AP022815:2540065-2540370 [Escherichia coli]
CTGCCCTGCACCGTGACGCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGC
CGGTATCAGAGGCCTGTTCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAC
TCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCC
GATACCCTCAGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A3W4SUB1

References