Detailed information of TA system TA036511

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4944472..4945273
• Replicon: chromosome
• Accession: NZ_AP022811
• Organism: Escherichia coli strain JE86-ST02

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: D3GUT5
• Locus tag: JLZ98_RS24305
• Protein ID: WP_001094430.1
• Coordinates: 4944472..4944849 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: JLZ98_RS24310
• Protein ID: WP_096855618.1
• Coordinates: 4944896..4945273 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLZ98_RS24285	4940564..4942102	-	1539	WP_001187182.1	lysine decarboxylation/transport transcriptional activator CadC	-
JLZ98_RS24290	4942851..4943693	-	843	WP_096855615.1	DUF4942 domain-containing protein	-
JLZ98_RS24295	4943778..4943975	-	198	WP_001374283.1	DUF957 domain-containing protein	-
JLZ98_RS24300	4943987..4944475	-	489	WP_000761666.1	hypothetical protein	-
JLZ98_RS24305	4944472..4944849	-	378	WP_001094430.1	TA system toxin CbtA family protein	Toxin
JLZ98_RS24310	4944896..4945273	-	378	WP_096855618.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JLZ98_RS24315	4945347..4945568	-	222	WP_096855616.1	DUF987 domain-containing protein	-
JLZ98_RS24320	4945637..4946113	-	477	WP_122997650.1	RadC family protein	-
JLZ98_RS24325	4946128..4946607	-	480	WP_032233447.1	antirestriction protein	-
JLZ98_RS24330	4946707..4946847	+	141	WP_000997937.1	hypothetical protein	-
JLZ98_RS24335	4946873..4947691	-	819	WP_001175155.1	DUF945 domain-containing protein	-
JLZ98_RS24340	4947781..4948014	-	234	WP_001278293.1	DUF905 family protein	-
JLZ98_RS24345	4948020..4948697	-	678	WP_200984377.1	hypothetical protein	-
JLZ98_RS24350	4948845..4949525	-	681	WP_096855617.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	iroB	4933075..4997193	64118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13971.82 Da
• Isoelectric Point: 6.8608

>T36511 WP_001094430.1 NZ_AP022811:c4944849-4944472 [Escherichia coli]
MNTLPDTHVREASGCPSPITIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T36511 NZ_AP022811:c4944849-4944472 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAAGCGAAACAATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13725.59 Da
• Isoelectric Point: 6.7380

>AT36511 WP_096855618.1 NZ_AP022811:c4945273-4944896 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPATTV

Nucleotide

• Length: 378 bp

>AT36511 NZ_AP022811:c4945273-4944896 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0Y6M7