Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4406886..4407721 Replicon chromosome
Accession NZ_AP022811
Organism Escherichia coli strain JE86-ST02

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3K4KCT6
Locus tag JLZ98_RS21845 Protein ID WP_000854827.1
Coordinates 4407344..4407721 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1Y2XNS0
Locus tag JLZ98_RS21840 Protein ID WP_001403016.1
Coordinates 4406886..4407254 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ98_RS21800 4402971..4403426 + 456 WP_000581502.1 hypothetical protein -
JLZ98_RS21805 4403501..4403734 + 234 WP_001119729.1 DUF905 family protein -
JLZ98_RS21810 4403834..4404655 + 822 WP_032266500.1 DUF945 domain-containing protein -
JLZ98_RS21815 4404918..4405391 + 474 WP_000855084.1 antirestriction protein -
JLZ98_RS21820 4405407..4405883 + 477 WP_001186743.1 RadC family protein -
JLZ98_RS21825 4405952..4406173 + 222 WP_001220314.1 DUF987 domain-containing protein -
JLZ98_RS21830 4406192..4406413 + 222 WP_000086676.1 hypothetical protein -
JLZ98_RS21835 4406543..4406836 + 294 Protein_4263 antitoxin of the YeeV-YeeU toxin-antitoxin system -
JLZ98_RS21840 4406886..4407254 + 369 WP_001403016.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLZ98_RS21845 4407344..4407721 + 378 WP_000854827.1 type IV toxin-antitoxin system toxin CbtA Toxin
JLZ98_RS21850 4407718..4408206 + 489 WP_000761674.1 hypothetical protein -
JLZ98_RS21855 4408218..4408415 + 198 WP_000839236.1 DUF957 domain-containing protein -
JLZ98_RS21860 4408500..4409345 + 846 WP_096855538.1 DUF4942 domain-containing protein -
JLZ98_RS21865 4410137..4411321 + 1185 WP_001172876.1 sugar efflux transporter -
JLZ98_RS21870 4411432..4412355 + 924 WP_000535960.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14045.05 Da        Isoelectric Point: 7.8840

>T36508 WP_000854827.1 NZ_AP022811:4407344-4407721 [Escherichia coli]
MKTLPVLPGQSASSRPSPVEIWQILLARLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKR

Download         Length: 378 bp

>T36508 NZ_AP022811:4407344-4407721 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGTCGGCCAGTTCACGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGGC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAACTACAGAACGGTAAATGACATTACCCAGGGTAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13648.33 Da        Isoelectric Point: 5.9582

>AT36508 WP_001403016.1 NZ_AP022811:4406886-4407254 [Escherichia coli]
VSDTLPETNNPNDNHDRPWWGLPCTATPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT36508 NZ_AP022811:4406886-4407254 [Escherichia coli]
GTGTCAGACACGCTCCCTGAGACAAATAACCCCAACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGCGAC
ACCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGCAACCAGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGGCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K4KCT6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y2XNS0

References