Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2515089..2515857 Replicon chromosome
Accession NZ_AP022811
Organism Escherichia coli strain JE86-ST02

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JLZ98_RS12740 Protein ID WP_000854814.1
Coordinates 2515483..2515857 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3W4SUB1
Locus tag JLZ98_RS12735 Protein ID WP_044863316.1
Coordinates 2515089..2515394 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ98_RS12705 2511930..2512385 + 456 WP_000581504.1 hypothetical protein -
JLZ98_RS12710 2512464..2512697 + 234 WP_032173243.1 DUF905 family protein -
JLZ98_RS12715 2512797..2513615 + 819 WP_137519561.1 DUF945 domain-containing protein -
JLZ98_RS12720 2513697..2514176 + 480 WP_032241953.1 antirestriction protein -
JLZ98_RS12725 2514192..2514668 + 477 WP_001186726.1 RadC family protein -
JLZ98_RS12730 2514731..2514952 + 222 WP_000692323.1 DUF987 domain-containing protein -
JLZ98_RS12735 2515089..2515394 + 306 WP_044863316.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLZ98_RS12740 2515483..2515857 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JLZ98_RS12745 2515854..2516048 + 195 WP_000988600.1 hypothetical protein -
JLZ98_RS12750 2516061..2516174 + 114 WP_001161660.1 DUF957 domain-containing protein -
JLZ98_RS12755 2516463..2516636 - 174 WP_071592185.1 transposase domain-containing protein -
JLZ98_RS12760 2516663..2516845 + 183 WP_001016348.1 hypothetical protein -
JLZ98_RS12765 2516946..2517275 - 330 WP_000450409.1 DUF496 family protein -
JLZ98_RS12770 2517447..2517965 - 519 Protein_2492 hypothetical protein -
JLZ98_RS12775 2518060..2519040 - 981 WP_000399648.1 IS110-like element IS621 family transposase -
JLZ98_RS12780 2519104..2519784 - 681 WP_001200880.1 FUSC family protein -
JLZ98_RS12785 2519982..2520455 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2518060..2519040 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(2-96)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T36501 WP_000854814.1 NZ_AP022811:2515483-2515857 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T36501 NZ_AP022811:2515483-2515857 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11250.00 Da        Isoelectric Point: 7.2621

>AT36501 WP_044863316.1 NZ_AP022811:2515089-2515394 [Escherichia coli]
MPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELNPRHQHTVTLYAKGLTCKA
DTLSSCGYVYLAVYPTPEMKN

Download         Length: 306 bp

>AT36501 NZ_AP022811:2515089-2515394 [Escherichia coli]
CTGCCCTGCACCGTGACGCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGC
CGGTATCAGAGGCCTGTTCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAC
TCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCC
GATACCCTCAGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A3W4SUB1

References