36482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 4179558..4180120 Replicon chromosome
Accession NZ_AP022671
Organism Nitrospira sp. KM1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag W02_RS19755 Protein ID WP_173050884.1
Coordinates 4179791..4180120 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag W02_RS19750 Protein ID WP_173050882.1
Coordinates 4179558..4179794 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W02_RS19735 4175221..4176984 + 1764 WP_173050876.1 aspartate--tRNA ligase -
W02_RS19740 4177001..4178164 + 1164 WP_173050878.1 chorismate synthase -
W02_RS19745 4178179..4178979 + 801 WP_173050880.1 ATP-binding cassette domain-containing protein -
W02_RS19750 4179558..4179794 + 237 WP_173050882.1 DUF433 domain-containing protein Antitoxin
W02_RS19755 4179791..4180120 + 330 WP_173050884.1 DUF5615 family PIN-like protein Toxin
W02_RS19760 4180552..4180788 + 237 WP_173050886.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
W02_RS19765 4180949..4181224 + 276 WP_173050888.1 type II toxin-antitoxin system VapC family toxin -
W02_RS19770 4181208..4181570 - 363 WP_173050890.1 transposase -
W02_RS21460 4181800..4182336 - 537 WP_197742077.1 hypothetical protein -
W02_RS19780 4182512..4183468 - 957 WP_173050892.1 S1C family serine protease -
W02_RS19785 4183568..4184023 - 456 WP_173050894.1 hypothetical protein -
W02_RS19790 4184024..4184887 - 864 WP_173050895.1 zinc metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-77)

Antitoxin

Protein of unknown function DUF433

(9-64)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12159.06 Da        Isoelectric Point: 4.3507

>T36482 WP_173050884.1 NZ_AP022671:4179791-4180120 [Nitrospira sp. KM1]
MKFLVDANLPPGLAVWLCEHAHESIHVSDQPGLTLDDRAVFEFARRNDYIIMTKDEDFATLAILVDGPAAVVWLRLGNAT
NIALRNWLEPLLPDILQRLAAGETLIEIV

Download         Length: 330 bp

>T36482 NZ_AP022671:4179791-4180120 [Nitrospira sp. KM1]
ATGAAGTTCCTCGTTGACGCGAATCTCCCACCCGGCCTTGCCGTTTGGCTCTGCGAGCATGCACACGAATCGATTCACGT
TAGTGATCAGCCTGGTTTGACTCTCGACGATCGCGCGGTCTTCGAATTCGCCCGCCGAAACGACTATATCATCATGACAA
AGGACGAGGACTTTGCCACGCTGGCCATACTTGTCGATGGTCCGGCAGCGGTTGTCTGGTTGCGATTGGGCAATGCCACT
AATATTGCCCTTCGGAATTGGTTGGAACCGCTGCTTCCGGATATCCTGCAGCGCCTTGCCGCCGGCGAAACACTTATCGA
GATTGTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8695.12 Da        Isoelectric Point: 8.5042

>AT36482 WP_173050882.1 NZ_AP022671:4179558-4179794 [Nitrospira sp. KM1]
MKTTLLHRITIEPGKCGGRPCIRGLRIRVQDILDMLAAGTSEKEILHDYPYLERDDIRAAMAYAAAYLNHSIVPARSG

Download         Length: 237 bp

>AT36482 NZ_AP022671:4179558-4179794 [Nitrospira sp. KM1]
ATGAAGACAACCCTTCTCCATCGCATCACCATCGAGCCCGGGAAATGCGGCGGGCGTCCTTGTATCCGCGGGCTGCGTAT
CCGTGTGCAGGACATCCTCGATATGCTGGCGGCTGGTACCTCCGAGAAAGAGATCCTACATGACTATCCATACTTGGAGC
GCGACGACATCCGCGCAGCCATGGCCTATGCCGCCGCTTATTTGAACCATAGTATCGTGCCTGCACGGTCTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References