Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 625782..626192 Replicon chromosome
Accession NZ_AP022671
Organism Nitrospira sp. KM1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag W02_RS02920 Protein ID WP_173044642.1
Coordinates 625782..625934 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag W02_RS02925 Protein ID WP_173044644.1
Coordinates 625980..626192 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W02_RS02885 621207..621668 - 462 WP_197742124.1 cupin domain-containing protein -
W02_RS02890 621948..622274 + 327 WP_173044630.1 hypothetical protein -
W02_RS02895 622429..622938 - 510 WP_173044632.1 response regulator -
W02_RS02900 623168..623659 - 492 WP_173044634.1 response regulator -
W02_RS02905 624049..624336 + 288 WP_197742125.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
W02_RS02910 624349..624618 + 270 WP_197742210.1 helix-turn-helix domain-containing protein -
W02_RS02915 624888..625127 - 240 WP_173044640.1 DUF2283 domain-containing protein -
W02_RS02920 625782..625934 + 153 WP_173044642.1 type II toxin-antitoxin system HicA family toxin Toxin
W02_RS02925 625980..626192 + 213 WP_173044644.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
W02_RS02930 626830..627138 + 309 WP_173044646.1 HigA family addiction module antidote protein -
W02_RS02935 627449..627724 + 276 WP_173044648.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
W02_RS02940 627721..627957 + 237 WP_173044650.1 hypothetical protein -
W02_RS02945 628261..628707 - 447 WP_173044652.1 hypothetical protein -
W02_RS02950 629385..630257 + 873 WP_173044654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-49)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5412.16 Da        Isoelectric Point: 10.4898

>T36481 WP_173044642.1 NZ_AP022671:625782-625934 [Nitrospira sp. KM1]
VKVGDVLDKLREDGWFIVATKGSHRQFKHASKPGRVTVAGKPSDDLPPGN

Download         Length: 153 bp

>T36481 NZ_AP022671:625782-625934 [Nitrospira sp. KM1]
GTGAAGGTTGGCGATGTACTGGATAAGCTACGAGAAGATGGTTGGTTCATTGTTGCCACGAAGGGCAGTCATCGCCAATT
TAAGCATGCCAGTAAACCTGGCCGCGTCACTGTGGCTGGCAAACCAAGCGATGACTTGCCTCCTGGAAACTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7451.53 Da        Isoelectric Point: 4.2498

>AT36481 WP_173044644.1 NZ_AP022671:625980-626192 [Nitrospira sp. KM1]
MRYAVVIEKAPANYAAYVPDLPGCIATGATVAETESLIREAIEFHLAGLKEDGLPIPLPSSHVEYVDVPA

Download         Length: 213 bp

>AT36481 NZ_AP022671:625980-626192 [Nitrospira sp. KM1]
ATGCGTTATGCTGTGGTGATAGAAAAAGCACCCGCGAATTATGCGGCATATGTTCCGGACCTTCCCGGCTGCATCGCCAC
GGGTGCCACCGTTGCAGAAACCGAGTCGCTCATCCGTGAAGCGATTGAGTTTCATTTAGCGGGACTCAAAGAGGATGGCC
TTCCTATTCCTCTTCCAAGCAGCCACGTCGAATACGTGGATGTTCCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References