Detailed information of TA system TA036481

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 625782..626192
• Replicon: chromosome
• Accession: NZ_AP022671
• Organism: Nitrospira sp. KM1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: W02_RS02920
• Protein ID: WP_173044642.1
• Coordinates: 625782..625934 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: W02_RS02925
• Protein ID: WP_173044644.1
• Coordinates: 625980..626192 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
W02_RS02885	621207..621668	-	462	WP_197742124.1	cupin domain-containing protein	-
W02_RS02890	621948..622274	+	327	WP_173044630.1	hypothetical protein	-
W02_RS02895	622429..622938	-	510	WP_173044632.1	response regulator	-
W02_RS02900	623168..623659	-	492	WP_173044634.1	response regulator	-
W02_RS02905	624049..624336	+	288	WP_197742125.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
W02_RS02910	624349..624618	+	270	WP_197742210.1	helix-turn-helix domain-containing protein	-
W02_RS02915	624888..625127	-	240	WP_173044640.1	DUF2283 domain-containing protein	-
W02_RS02920	625782..625934	+	153	WP_173044642.1	type II toxin-antitoxin system HicA family toxin	Toxin
W02_RS02925	625980..626192	+	213	WP_173044644.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
W02_RS02930	626830..627138	+	309	WP_173044646.1	HigA family addiction module antidote protein	-
W02_RS02935	627449..627724	+	276	WP_173044648.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
W02_RS02940	627721..627957	+	237	WP_173044650.1	hypothetical protein	-
W02_RS02945	628261..628707	-	447	WP_173044652.1	hypothetical protein	-
W02_RS02950	629385..630257	+	873	WP_173044654.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-49)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-64)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5412.16 Da
• Isoelectric Point: 10.4898

>T36481 WP_173044642.1 NZ_AP022671:625782-625934 [Nitrospira sp. KM1]
VKVGDVLDKLREDGWFIVATKGSHRQFKHASKPGRVTVAGKPSDDLPPGN

Nucleotide

• Length: 153 bp

>T36481 NZ_AP022671:625782-625934 [Nitrospira sp. KM1]
GTGAAGGTTGGCGATGTACTGGATAAGCTACGAGAAGATGGTTGGTTCATTGTTGCCACGAAGGGCAGTCATCGCCAATT
TAAGCATGCCAGTAAACCTGGCCGCGTCACTGTGGCTGGCAAACCAAGCGATGACTTGCCTCCTGGAAACTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7451.53 Da
• Isoelectric Point: 4.2498

>AT36481 WP_173044644.1 NZ_AP022671:625980-626192 [Nitrospira sp. KM1]
MRYAVVIEKAPANYAAYVPDLPGCIATGATVAETESLIREAIEFHLAGLKEDGLPIPLPSSHVEYVDVPA

Nucleotide

• Length: 213 bp

>AT36481 NZ_AP022671:625980-626192 [Nitrospira sp. KM1]
ATGCGTTATGCTGTGGTGATAGAAAAAGCACCCGCGAATTATGCGGCATATGTTCCGGACCTTCCCGGCTGCATCGCCAC
GGGTGCCACCGTTGCAGAAACCGAGTCGCTCATCCGTGAAGCGATTGAGTTTCATTTAGCGGGACTCAAAGAGGATGGCC
TTCCTATTCCTCTTCCAAGCAGCCACGTCGAATACGTGGATGTTCCTGCCTAA