Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1238006..1238477 | Replicon | chromosome |
| Accession | NZ_AP022650 | ||
| Organism | Escherichia coli strain 09-02E | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | HRS14_RS05975 | Protein ID | WP_001303511.1 |
| Coordinates | 1238006..1238284 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | HRS14_RS05980 | Protein ID | WP_001302048.1 |
| Coordinates | 1238286..1238477 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HRS14_RS05940 | 1233191..1233460 | - | 270 | WP_000003742.1 | excisionase | - |
| HRS14_RS05945 | 1233522..1235993 | - | 2472 | WP_032284123.1 | exonuclease | - |
| HRS14_RS05950 | 1236089..1236277 | - | 189 | WP_000199480.1 | DUF1482 family protein | - |
| HRS14_RS05955 | 1236274..1236462 | - | 189 | WP_000449172.1 | cell division inhibitor | - |
| HRS14_RS05960 | 1236957..1237223 | + | 267 | WP_012601410.1 | hypothetical protein | - |
| HRS14_RS05965 | 1237212..1237550 | - | 339 | WP_000394541.1 | hypothetical protein | - |
| HRS14_RS05970 | 1237562..1237714 | - | 153 | WP_000380313.1 | DUF1391 family protein | - |
| HRS14_RS05975 | 1238006..1238284 | - | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HRS14_RS05980 | 1238286..1238477 | - | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| HRS14_RS05985 | 1238498..1238869 | - | 372 | WP_001169687.1 | hypothetical protein | - |
| HRS14_RS05990 | 1238968..1239270 | + | 303 | WP_000172738.1 | transcriptional regulator | - |
| HRS14_RS05995 | 1239267..1239692 | + | 426 | WP_000693943.1 | Rha family transcriptional regulator | - |
| HRS14_RS06000 | 1239715..1240677 | + | 963 | WP_000095673.1 | helix-turn-helix domain-containing protein | - |
| HRS14_RS06005 | 1240718..1241140 | + | 423 | WP_021534702.1 | DUF977 family protein | - |
| HRS14_RS06010 | 1241137..1241391 | + | 255 | WP_000004322.1 | hypothetical protein | - |
| HRS14_RS06015 | 1241384..1241695 | + | 312 | WP_021534703.1 | hypothetical protein | - |
| HRS14_RS06020 | 1241824..1242006 | + | 183 | WP_001224665.1 | hypothetical protein | - |
| HRS14_RS06025 | 1241999..1242175 | + | 177 | WP_021534704.1 | hypothetical protein | - |
| HRS14_RS06030 | 1242172..1242532 | + | 361 | Protein_1181 | hypothetical protein | - |
| HRS14_RS06035 | 1242533..1242747 | + | 215 | Protein_1182 | hypothetical protein | - |
| HRS14_RS06040 | 1242749..1242967 | + | 219 | WP_001142588.1 | DUF4014 family protein | - |
| HRS14_RS06045 | 1242969..1243232 | + | 264 | WP_000224216.1 | hypothetical protein | - |
| HRS14_RS06050 | 1243243..1243410 | + | 168 | WP_000207997.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1227837..1286933 | 59096 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T36454 WP_001303511.1 NZ_AP022650:c1238284-1238006 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T36454 NZ_AP022650:c1238284-1238006 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT36454 WP_001302048.1 NZ_AP022650:c1238477-1238286 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT36454 NZ_AP022650:c1238477-1238286 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|