Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4730250..4730866 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HRR29_RS22755 Protein ID WP_080277799.1
Coordinates 4730250..4730621 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HRR29_RS22760 Protein ID WP_033146961.1
Coordinates 4730624..4730866 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS22740 4727750..4728652 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
HRR29_RS22745 4728649..4729284 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
HRR29_RS22750 4729281..4730210 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
HRR29_RS22755 4730250..4730621 - 372 WP_080277799.1 type II toxin-antitoxin system VapC family toxin Toxin
HRR29_RS22760 4730624..4730866 - 243 WP_033146961.1 ribbon-helix-helix domain-containing protein Antitoxin
HRR29_RS22765 4731066..4731986 + 921 WP_033146962.1 alpha/beta hydrolase -
HRR29_RS22770 4731995..4732936 - 942 WP_033146963.1 fatty acid biosynthesis protein FabY -
HRR29_RS22775 4732981..4733418 - 438 WP_033146964.1 D-tyrosyl-tRNA(Tyr) deacylase -
HRR29_RS22780 4733415..4734296 - 882 WP_033146965.1 virulence factor BrkB family protein -
HRR29_RS22785 4734290..4734889 - 600 WP_033146966.1 glucose-1-phosphatase -
HRR29_RS22790 4734978..4735448 - 471 WP_033146967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13687.90 Da        Isoelectric Point: 6.9789

>T36435 WP_080277799.1 NZ_AP022628:c4730621-4730250 [Enterobacter asburiae]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFLGITGVVSPYQL

Download         Length: 372 bp

>T36435 NZ_AP022628:c4730621-4730250 [Enterobacter asburiae]
ATGGAGCACATGGCGGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCTCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTTTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAGTTGCCCGTTAATCTCACGCAA
TACGAAAGACTTTTTGGGCATCACCGGGGTCGTTTCACCTTACCAGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.67 Da        Isoelectric Point: 4.2917

>AT36435 WP_033146961.1 NZ_AP022628:c4730866-4730624 [Enterobacter asburiae]
MILSADLDMGRILIDLSEDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp

>AT36435 NZ_AP022628:c4730866-4730624 [Enterobacter asburiae]
ATGATTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGAAGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGGCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References