Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3929479..3930136 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag HRR29_RS18790 Protein ID WP_021242050.1
Coordinates 3929479..3929889 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag HRR29_RS18795 Protein ID WP_010435322.1
Coordinates 3929870..3930136 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS18770 3925472..3927205 - 1734 WP_033146589.1 single-stranded-DNA-specific exonuclease RecJ -
HRR29_RS18775 3927211..3927924 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HRR29_RS18780 3927953..3928849 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
HRR29_RS18785 3928951..3929472 + 522 WP_023309099.1 flavodoxin FldB -
HRR29_RS18790 3929479..3929889 - 411 WP_021242050.1 protein YgfX Toxin
HRR29_RS18795 3929870..3930136 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
HRR29_RS18800 3930431..3931411 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
HRR29_RS18805 3931486..3932145 - 660 WP_033146591.1 hemolysin III family protein -
HRR29_RS18810 3932311..3932622 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
HRR29_RS18815 3932674..3933405 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
HRR29_RS18820 3933522..3934955 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T36434 WP_021242050.1 NZ_AP022628:c3929889-3929479 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T36434 NZ_AP022628:c3929889-3929479 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTTCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT36434 WP_010435322.1 NZ_AP022628:c3930136-3929870 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT36434 NZ_AP022628:c3930136-3929870 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References