Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3225096..3225622 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HRR29_RS15475 Protein ID WP_000323025.1
Coordinates 3225096..3225383 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HRR29_RS15480 Protein ID WP_000534858.1
Coordinates 3225383..3225622 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS15460 3221672..3222610 - 939 WP_014170919.1 1-phosphofructokinase -
HRR29_RS15465 3222610..3223740 - 1131 WP_033146038.1 fused PTS fructose transporter subunit IIA/HPr protein -
HRR29_RS15470 3224102..3225037 + 936 Protein_3028 MFS transporter -
HRR29_RS15475 3225096..3225383 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HRR29_RS15480 3225383..3225622 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HRR29_RS15485 3225647..3225952 + 306 WP_001326990.1 hypothetical protein -
HRR29_RS15490 3226155..3226487 + 333 WP_001317460.1 FlxA-like family protein -
HRR29_RS15495 3226924..3228264 - 1341 WP_004196353.1 ISNCY family transposase -
HRR29_RS15500 3228340..3228600 + 261 Protein_3034 MFS transporter -
HRR29_RS15505 3228597..3228851 - 255 WP_033146563.1 YkgJ family cysteine cluster protein -
HRR29_RS15510 3229016..3229588 + 573 WP_008500940.1 elongation factor P-like protein YeiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T36432 WP_000323025.1 NZ_AP022628:c3225383-3225096 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T36432 NZ_AP022628:c3225383-3225096 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT36432 WP_000534858.1 NZ_AP022628:c3225622-3225383 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT36432 NZ_AP022628:c3225622-3225383 [Enterobacter asburiae]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References