Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 3040959..3041549 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HRR29_RS14650 Protein ID WP_033145927.1
Coordinates 3040959..3041291 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag HRR29_RS14655 Protein ID WP_033145928.1
Coordinates 3041292..3041549 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS14630 3036120..3036923 - 804 WP_003036327.1 TIGR02391 family protein -
HRR29_RS14635 3036945..3037424 - 480 WP_031617716.1 hypothetical protein -
HRR29_RS14640 3037503..3038441 - 939 WP_003036321.1 hypothetical protein -
HRR29_RS14645 3039277..3040638 + 1362 WP_003036316.1 hypothetical protein -
HRR29_RS14650 3040959..3041291 - 333 WP_033145927.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HRR29_RS14655 3041292..3041549 - 258 WP_033145928.1 antitoxin Antitoxin
HRR29_RS14660 3041841..3042230 - 390 WP_033145929.1 RidA family protein -
HRR29_RS14665 3042372..3043292 + 921 WP_033145930.1 LysR family transcriptional regulator -
HRR29_RS14670 3043368..3043670 - 303 WP_029741460.1 XRE family transcriptional regulator -
HRR29_RS14675 3043675..3044028 - 354 WP_033145931.1 type II toxin-antitoxin system RelE/ParE family toxin -
HRR29_RS14680 3044206..3045099 - 894 WP_033145932.1 LysR family transcriptional regulator -
HRR29_RS14685 3045270..3045878 + 609 WP_080277780.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3024951..3052897 27946


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11828.65 Da        Isoelectric Point: 9.4051

>T36430 WP_033145927.1 NZ_AP022628:c3041291-3040959 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMSARNGMRLERIPDAVINEVLARLDAILN

Download         Length: 333 bp

>T36430 NZ_AP022628:c3041291-3040959 [Enterobacter asburiae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGAACAACAACAACGGGCGTTATTCGCTGCGATCAGCCCAGAACCATT
GATATGTCTGCCCGGAACGGCATGCGGCTGGAACGTATACCTGACGCGGTTATAAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTGAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9464.92 Da        Isoelectric Point: 4.4737

>AT36430 WP_033145928.1 NZ_AP022628:c3041549-3041292 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT36430 NZ_AP022628:c3041549-3041292 [Enterobacter asburiae]
ATGTATACAACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAACGCTGGAACT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCTCACTATTCGC
TTGAGGAACTGCTGGCGCAGTGCGATCCGCACGCTGAAATGAGCGAAGAGGAGCGGGAATGGATCGATGCGCCTGCGGTG
GGCAGGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References