Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1465311..1465837 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag HRR29_RS06955 Protein ID WP_000323025.1
Coordinates 1465311..1465598 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag HRR29_RS06960 Protein ID WP_000534858.1
Coordinates 1465598..1465837 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS06935 1460407..1461930 + 1524 WP_033145004.1 efflux transporter outer membrane subunit -
HRR29_RS06940 1462033..1463073 + 1041 WP_033145005.1 aldo/keto reductase -
HRR29_RS06945 1463222..1464598 + 1377 WP_033145006.1 glycoside hydrolase family 1 protein -
HRR29_RS06950 1464650..1465252 + 603 Protein_1343 PTS sugar transporter subunit IIC -
HRR29_RS06955 1465311..1465598 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HRR29_RS06960 1465598..1465837 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HRR29_RS06965 1465862..1466167 + 306 WP_001326990.1 hypothetical protein -
HRR29_RS06970 1466370..1466702 + 333 WP_001317460.1 FlxA-like family protein -
HRR29_RS06975 1467139..1468479 - 1341 WP_004196353.1 ISNCY family transposase -
HRR29_RS06980 1468536..1469288 + 753 Protein_1349 PTS sugar transporter subunit IIC -
HRR29_RS06985 1469304..1470020 + 717 WP_033145008.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T36420 WP_000323025.1 NZ_AP022628:c1465598-1465311 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T36420 NZ_AP022628:c1465598-1465311 [Enterobacter asburiae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT36420 WP_000534858.1 NZ_AP022628:c1465837-1465598 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT36420 NZ_AP022628:c1465837-1465598 [Enterobacter asburiae]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References