Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1054580..1055200 Replicon chromosome
Accession NZ_AP022628
Organism Enterobacter asburiae strain A2563

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag HRR29_RS04940 Protein ID WP_008499287.1
Coordinates 1054580..1054798 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag HRR29_RS04945 Protein ID WP_008499288.1
Coordinates 1054826..1055200 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRR29_RS04910 1050594..1050854 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
HRR29_RS04915 1050857..1050997 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
HRR29_RS04920 1050994..1051704 - 711 WP_033144788.1 GNAT family N-acetyltransferase -
HRR29_RS04925 1051806..1053266 + 1461 WP_033144789.1 PLP-dependent aminotransferase family protein -
HRR29_RS04930 1053238..1053705 - 468 WP_023310598.1 hypothetical protein -
HRR29_RS04935 1053823..1054374 - 552 WP_033144790.1 maltose O-acetyltransferase -
HRR29_RS04940 1054580..1054798 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
HRR29_RS04945 1054826..1055200 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
HRR29_RS04950 1055712..1058858 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
HRR29_RS04955 1058881..1060074 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T36419 WP_008499287.1 NZ_AP022628:c1054798-1054580 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T36419 NZ_AP022628:c1054798-1054580 [Enterobacter asburiae]
ATGTCTGATAAACCACTCACAAAAATCGATTATTTGATGCGCTTACGGCGTTGTCAGTCAATTGACACGCTTGAGCGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TGACAATGAATAAACTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT36419 WP_008499288.1 NZ_AP022628:c1055200-1054826 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT36419 NZ_AP022628:c1055200-1054826 [Enterobacter asburiae]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGACCCAACATCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCGCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References