Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3168959..3169630 Replicon chromosome
Accession NZ_AP022620
Organism Mycolicibacterium anyangense strain JCM 30275

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N35_RS14830 Protein ID WP_163804943.1
Coordinates 3168959..3169405 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N35_RS14835 Protein ID WP_163804944.1
Coordinates 3169418..3169630 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N35_RS14805 3164946..3165833 - 888 WP_163807687.1 universal stress protein -
G6N35_RS14810 3166003..3166644 + 642 WP_163807688.1 response regulator transcription factor -
G6N35_RS14815 3166637..3168199 + 1563 WP_163804940.1 GAF domain-containing sensor histidine kinase -
G6N35_RS14820 3168218..3168445 - 228 WP_163804941.1 DUF3562 domain-containing protein -
G6N35_RS14825 3168588..3168962 + 375 WP_163804942.1 hypothetical protein -
G6N35_RS14830 3168959..3169405 - 447 WP_163804943.1 SRPBCC family protein Toxin
G6N35_RS14835 3169418..3169630 - 213 WP_163804944.1 antitoxin Antitoxin
G6N35_RS14840 3169633..3172074 - 2442 WP_163804945.1 HAD-IC family P-type ATPase -
G6N35_RS14845 3172071..3173654 - 1584 WP_179967361.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-144)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16149.71 Da        Isoelectric Point: 7.4699

>T36412 WP_163804943.1 NZ_AP022620:c3169405-3168959 [Mycolicibacterium anyangense]
MAKLSVSVDVPLPPEQAWQHASDLSRYKEWLTIHRVWRSTLPETLDKGTEVESIVEVKGMPNRVKWTIVHFKPPEAMTLN
GAGVGGVKVKLIGKVRPHDTDADSSVVTMDVHLGGPALFGPIGMLVAGALRSDIKESLDRFVTVFSPA

Download         Length: 447 bp

>T36412 NZ_AP022620:c3169405-3168959 [Mycolicibacterium anyangense]
ATGGCGAAACTCTCCGTATCCGTAGACGTTCCGTTACCGCCCGAGCAAGCCTGGCAGCACGCCTCTGACCTGTCCCGGTA
CAAGGAATGGCTCACCATTCACCGGGTCTGGCGCTCCACGCTGCCCGAGACCCTCGACAAGGGCACCGAGGTGGAGTCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGCGTGAAGTGGACCATCGTGCACTTCAAGCCGCCGGAGGCGATGACGCTCAAC
GGGGCCGGCGTCGGGGGAGTGAAGGTCAAACTCATCGGCAAGGTCCGGCCGCACGACACCGACGCCGACTCGTCGGTGGT
CACCATGGATGTCCACCTGGGCGGTCCGGCATTGTTCGGGCCGATCGGCATGCTGGTGGCCGGTGCGCTGCGCAGCGACA
TCAAGGAGTCGCTGGACCGGTTCGTGACGGTGTTCTCGCCCGCTTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7440.27 Da        Isoelectric Point: 4.4746

>AT36412 WP_163804944.1 NZ_AP022620:c3169630-3169418 [Mycolicibacterium anyangense]
MSFIDKAKEVLSQNADKVEAAIDKAGDIIDEKTQGKFSEAVDKVQDAAKSAVEKGAEAVKKTTDTDDKPA

Download         Length: 213 bp

>AT36412 NZ_AP022620:c3169630-3169418 [Mycolicibacterium anyangense]
ATGAGTTTCATCGACAAGGCCAAGGAAGTATTGAGCCAGAACGCCGACAAGGTGGAGGCGGCGATCGACAAGGCCGGCGA
CATCATCGACGAGAAGACCCAGGGCAAGTTCTCCGAGGCCGTCGACAAGGTCCAGGATGCGGCGAAGAGCGCTGTCGAGA
AGGGCGCCGAGGCCGTCAAGAAGACGACCGACACGGACGACAAGCCGGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References