Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2850418..2850983 Replicon chromosome
Accession NZ_AP022620
Organism Mycolicibacterium anyangense strain JCM 30275

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N35_RS13245 Protein ID WP_163804663.1
Coordinates 2850418..2850789 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N35_RS13250 Protein ID WP_163804664.1
Coordinates 2850786..2850983 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N35_RS13210 2846288..2847193 - 906 WP_163804657.1 2-hydroxyacid dehydrogenase -
G6N35_RS13215 2847197..2847331 - 135 WP_163804658.1 helix-turn-helix transcriptional regulator -
G6N35_RS13225 2847535..2847735 - 201 WP_163804659.1 hypothetical protein -
G6N35_RS13230 2847759..2848454 + 696 WP_163804660.1 guanylate cyclase -
G6N35_RS13235 2848455..2848961 - 507 WP_163804661.1 DUF1942 domain-containing protein -
G6N35_RS13240 2849296..2850405 + 1110 WP_197748424.1 sensor domain-containing diguanylate cyclase -
G6N35_RS13245 2850418..2850789 - 372 WP_163804663.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N35_RS13250 2850786..2850983 - 198 WP_163804664.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N35_RS13255 2851140..2851550 - 411 WP_163804665.1 VOC family protein -
G6N35_RS13260 2851624..2851992 - 369 WP_163804666.1 alkylphosphonate utilization protein -
G6N35_RS13265 2852071..2854770 - 2700 WP_163804667.1 hypothetical protein -
G6N35_RS13270 2854817..2855890 - 1074 WP_163804668.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13705.90 Da        Isoelectric Point: 6.2148

>T36411 WP_163804663.1 NZ_AP022620:c2850789-2850418 [Mycolicibacterium anyangense]
VILVDTAVWIDHLHARETKLVELLEVDRVGCHPLVIEEIALGSMAQRGVVLDLLENLRQFPTADHAEVMHLVDRRKVWGR
GLSAVDAHLLASVAMVDGAQLWTRDRRLKSACADVGIPTFDPR

Download         Length: 372 bp

>T36411 NZ_AP022620:c2850789-2850418 [Mycolicibacterium anyangense]
GTGATCCTGGTCGACACCGCAGTCTGGATCGACCATCTTCACGCCCGCGAGACCAAACTCGTGGAGCTGCTGGAAGTTGA
TCGAGTCGGCTGCCACCCGTTGGTCATAGAAGAGATTGCCCTCGGATCTATGGCCCAACGAGGTGTGGTGCTCGACTTGC
TGGAGAACTTGCGGCAGTTCCCCACTGCCGACCACGCCGAGGTTATGCATCTCGTCGATCGGCGGAAGGTGTGGGGGCGC
GGTCTGAGCGCTGTGGACGCCCACCTGTTGGCATCGGTCGCAATGGTTGACGGTGCTCAGCTCTGGACTCGGGACAGGCG
GCTGAAATCGGCCTGCGCAGATGTGGGTATCCCTACCTTCGACCCTCGTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6976.02 Da        Isoelectric Point: 11.4058

>AT36411 WP_163804664.1 NZ_AP022620:c2850983-2850786 [Mycolicibacterium anyangense]
VRTTVTIDDELLAKAAELTGVHENVALLKQGLQTLIRVESARRLAALGGTDPKATAAPRRRGQTR

Download         Length: 198 bp

>AT36411 NZ_AP022620:c2850983-2850786 [Mycolicibacterium anyangense]
GTGAGGACGACGGTCACCATCGATGACGAGCTGCTCGCAAAGGCTGCTGAACTCACTGGTGTGCACGAGAACGTCGCACT
ACTCAAGCAGGGCTTGCAAACCCTCATCCGTGTGGAGAGTGCTAGGCGCCTTGCCGCGCTAGGCGGAACGGACCCGAAGG
CGACGGCCGCTCCGCGGCGGCGCGGCCAGACTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References