Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2228102..2228679 Replicon chromosome
Accession NZ_AP022620
Organism Mycolicibacterium anyangense strain JCM 30275

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G6N35_RS10520 Protein ID WP_163804204.1
Coordinates 2228401..2228679 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G6N35_RS10515 Protein ID WP_163804203.1
Coordinates 2228102..2228404 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N35_RS10495 2224516..2226099 + 1584 WP_163804200.1 alkaline phosphatase family protein -
G6N35_RS10500 2226103..2227311 - 1209 WP_163804201.1 alpha/beta hydrolase -
G6N35_RS10505 2227604..2227921 + 318 WP_163804202.1 hypothetical protein -
G6N35_RS10515 2228102..2228404 + 303 WP_163804203.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N35_RS10520 2228401..2228679 + 279 WP_163804204.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N35_RS10525 2228751..2229350 + 600 WP_197748417.1 cadmium resistance transporter -
G6N35_RS10530 2229347..2230414 - 1068 WP_163804205.1 HoxN/HupN/NixA family nickel/cobalt transporter -
G6N35_RS10535 2230704..2231345 + 642 WP_163804206.1 YcnI family protein -
G6N35_RS10540 2231342..2231842 + 501 WP_163804207.1 copper resistance protein CopC -
G6N35_RS10545 2232001..2233041 + 1041 WP_163807597.1 HoxN/HupN/NixA family nickel/cobalt transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(30-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-80)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10538.98 Da        Isoelectric Point: 10.3975

>T36410 WP_163804204.1 NZ_AP022620:2228401-2228679 [Mycolicibacterium anyangense]
VTDQRYELIVAPTARKQLAETLTGAVAFAAYEFITGPLLDNPHRVGKRLRPPLEDRHSARRGTYRVIYRIDDEQRRVTVV
GVFSRADAYRNP

Download         Length: 279 bp

>T36410 NZ_AP022620:2228401-2228679 [Mycolicibacterium anyangense]
GTGACCGATCAGCGCTACGAATTGATCGTCGCCCCGACCGCCAGGAAACAACTGGCCGAAACCCTGACCGGTGCAGTGGC
CTTCGCAGCATATGAGTTCATCACTGGACCGCTGCTCGACAACCCACATCGAGTCGGCAAGCGATTGCGACCGCCGCTCG
AAGATCGTCACAGTGCCCGCCGCGGAACGTATCGCGTGATCTATCGGATTGACGACGAGCAGCGGCGCGTGACGGTCGTG
GGCGTGTTCAGCCGGGCAGACGCCTACCGAAACCCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10557.97 Da        Isoelectric Point: 4.3633

>AT36410 WP_163804203.1 NZ_AP022620:2228102-2228404 [Mycolicibacterium anyangense]
MVILMTMTEVSSLAETKARLSELVARVGEQHERVTVTVHGRPAAVLIAVDDLESLEETIAVLSDSAALRALSEADAELAR
GEGETEGDLAAAMQARRAGK

Download         Length: 303 bp

>AT36410 NZ_AP022620:2228102-2228404 [Mycolicibacterium anyangense]
ATGGTCATACTTATGACCATGACGGAAGTCAGCTCGCTCGCAGAGACCAAGGCCCGCCTGTCGGAGTTGGTGGCCCGTGT
CGGCGAGCAACACGAACGGGTCACCGTCACGGTCCACGGGCGTCCCGCGGCAGTCCTTATCGCTGTCGACGATCTGGAGT
CGCTCGAAGAGACCATTGCGGTCCTATCCGACTCTGCCGCGCTGCGCGCATTGAGCGAGGCCGACGCCGAACTAGCCCGA
GGCGAAGGAGAAACTGAGGGCGATCTCGCCGCAGCGATGCAGGCCCGTCGAGCCGGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References