Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1396124..1397105 Replicon chromosome
Accession NZ_AP022620
Organism Mycolicibacterium anyangense strain JCM 30275

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N35_RS06590 Protein ID WP_163803531.1
Coordinates 1396530..1397105 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N35_RS06585 Protein ID WP_163803530.1
Coordinates 1396124..1396513 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N35_RS06565 1392123..1392614 - 492 WP_163803527.1 hypothetical protein -
G6N35_RS06570 1392673..1393296 - 624 WP_163803528.1 TetR/AcrR family transcriptional regulator -
G6N35_RS06575 1393391..1394638 - 1248 WP_163803529.1 right-handed parallel beta-helix repeat-containing protein -
G6N35_RS06580 1395409..1396062 + 654 WP_179967321.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N35_RS06585 1396124..1396513 + 390 WP_163803530.1 hypothetical protein Antitoxin
G6N35_RS06590 1396530..1397105 + 576 WP_163803531.1 zeta toxin family protein Toxin
G6N35_RS06595 1397135..1397794 - 660 WP_163803532.1 hypothetical protein -
G6N35_RS06600 1397931..1398845 + 915 WP_163803533.1 nitronate monooxygenase -
G6N35_RS06605 1398860..1399750 + 891 WP_163803534.1 alpha/beta fold hydrolase -
G6N35_RS06610 1399767..1400606 + 840 WP_163803535.1 SDR family oxidoreductase -
G6N35_RS06615 1400647..1401420 + 774 WP_163803536.1 enoyl-CoA hydratase/isomerase family protein -
G6N35_RS06620 1401428..1401709 - 282 WP_170313114.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-155)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20385.45 Da        Isoelectric Point: 10.8365

>T36409 WP_163803531.1 NZ_AP022620:1396530-1397105 [Mycolicibacterium anyangense]
MKRLDLVVGPNGAGKSTFIALTLGPLLPGSVVVNADDIAKQRWPQDPAAHSYDAAKVAAATRSALIARGRSFIAETVFSH
PSKLDLLTEAQSAGYIVVVHVVLVPEDLAVQRVAHRVQAGGHHVPEDKIRQRHRRLVGLVTAAAIRADTATVYDNSRLAG
PRVIAQLAGGDLIGAPRWPSWTPQALAARWP

Download         Length: 576 bp

>T36409 NZ_AP022620:1396530-1397105 [Mycolicibacterium anyangense]
ATGAAGCGGCTCGACCTCGTGGTCGGCCCCAATGGTGCCGGCAAGTCCACGTTCATCGCCCTGACGCTCGGGCCGCTGTT
GCCCGGCAGCGTCGTCGTCAACGCCGACGACATCGCCAAACAGCGGTGGCCGCAGGATCCTGCGGCGCACTCCTACGACG
CTGCCAAGGTTGCCGCCGCGACCCGATCGGCACTGATCGCCCGCGGCCGGTCCTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAACTCGACCTGCTCACCGAGGCCCAATCGGCCGGCTACATCGTGGTGGTGCACGTCGTCCTGGTTCCGGAGGA
CTTGGCAGTCCAGCGGGTGGCCCACCGCGTCCAGGCCGGCGGCCATCACGTGCCGGAGGACAAGATCCGCCAACGCCACC
GTCGCCTGGTGGGTCTGGTCACCGCCGCAGCGATCCGCGCCGACACCGCGACCGTCTACGACAACAGCCGCCTCGCCGGG
CCACGCGTCATCGCCCAACTGGCCGGTGGGGATCTCATCGGGGCGCCGCGCTGGCCATCATGGACGCCGCAGGCCCTGGC
TGCCCGCTGGCCCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13642.94 Da        Isoelectric Point: 4.4943

>AT36409 WP_163803530.1 NZ_AP022620:1396124-1396513 [Mycolicibacterium anyangense]
MADVADRVIRMAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHSASRRRVEAALSGDLDLSDLTVEEGVVFNSEI
SAAIEENLTRTHYGHVLAAGGVTTVALDDAGDIVEYHPDGTSVVLSQDS

Download         Length: 390 bp

>AT36409 NZ_AP022620:1396124-1396513 [Mycolicibacterium anyangense]
ATGGCTGACGTCGCTGATCGCGTGATTCGGATGGCGGCCGACCTGGTGGACAGCGCAGCGGCCGAAGGCGCACGCCAGAG
CCGCTCGGCCAAGCAGCAACTGGACCACTGGGCGAGGGTCGGGCGGGCGGTGTCCAGCCAACACTCCGCCTCCCGGCGCC
GCGTCGAGGCAGCCCTGTCGGGTGATCTCGACCTGTCCGACCTCACCGTAGAAGAAGGCGTGGTGTTCAACTCGGAGATC
TCGGCCGCGATCGAGGAGAACCTGACCCGTACCCACTATGGTCATGTCCTCGCAGCCGGCGGCGTGACGACCGTGGCGCT
CGACGACGCTGGCGACATCGTCGAATACCACCCGGACGGGACCTCGGTGGTGCTGTCTCAGGACAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References