Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 1191979..1192640 Replicon chromosome
Accession NZ_AP022620
Organism Mycolicibacterium anyangense strain JCM 30275

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N35_RS05600 Protein ID WP_197748407.1
Coordinates 1191979..1192374 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N35_RS05605 Protein ID WP_163803360.1
Coordinates 1192374..1192640 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N35_RS05580 1188531..1188896 + 366 WP_163803355.1 nitrite reductase small subunit NirD -
G6N35_RS05585 1188868..1190013 + 1146 WP_163803356.1 uroporphyrinogen-III synthase -
G6N35_RS05590 1190010..1190744 + 735 WP_163803357.1 sirohydrochlorin chelatase -
G6N35_RS05595 1190692..1191972 + 1281 WP_163803358.1 threonine ammonia-lyase IlvA -
G6N35_RS05600 1191979..1192374 - 396 WP_197748407.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N35_RS05605 1192374..1192640 - 267 WP_163803360.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N35_RS05610 1192658..1193074 - 417 WP_163803361.1 hypothetical protein -
G6N35_RS05615 1193132..1194856 - 1725 WP_163803362.1 malto-oligosyltrehalose trehalohydrolase -
G6N35_RS05620 1194849..1197134 - 2286 WP_163803363.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 13938.11 Da        Isoelectric Point: 9.7367

>T36408 WP_197748407.1 NZ_AP022620:c1192374-1191979 [Mycolicibacterium anyangense]
MQLYLDTSALVKVVVAEPESPALRSYLNGHPQDIRFTAALSRTELLRAIGRSGSFDAVAHARRVLARLDTVALTHRLLDE
AGSLGPPSLRTLDAIHLAAALTAPALRALVTYDARLAHAAESIGIAVIAPR

Download         Length: 396 bp

>T36408 NZ_AP022620:c1192374-1191979 [Mycolicibacterium anyangense]
ATGCAGCTGTATCTGGACACCTCGGCCCTCGTCAAAGTCGTTGTCGCCGAACCTGAAAGCCCGGCGCTCAGGAGCTATCT
GAATGGCCACCCACAGGATATTCGCTTCACCGCCGCGCTGAGTAGAACCGAACTCCTGCGGGCTATCGGGCGAAGTGGTT
CGTTTGATGCCGTCGCACACGCCCGCCGCGTACTGGCCCGGCTCGACACGGTGGCGCTCACCCACCGATTGCTCGATGAA
GCCGGCTCGCTCGGTCCGCCCTCGTTACGAACGCTAGACGCCATCCATCTCGCCGCCGCGCTCACCGCTCCGGCGTTGCG
GGCGCTTGTCACCTACGACGCCCGGTTGGCGCACGCCGCCGAGTCGATCGGCATCGCCGTCATCGCGCCGCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9606.72 Da        Isoelectric Point: 5.1239

>AT36408 WP_163803360.1 NZ_AP022620:c1192640-1192374 [Mycolicibacterium anyangense]
MDRIGLRELRQHASRYVGRVASGESIEIAVRGRLVARLIPASDSGWDDLVQRGDVIPATSPHGLLDEPAGDYGVDGSAAL
EQLRREER

Download         Length: 267 bp

>AT36408 NZ_AP022620:c1192640-1192374 [Mycolicibacterium anyangense]
ATGGATCGGATCGGGCTGCGTGAACTGCGCCAGCACGCGAGCCGCTACGTCGGGAGGGTGGCCAGCGGCGAGTCTATCGA
GATCGCCGTCCGAGGTCGGCTGGTAGCTCGGTTGATCCCTGCCTCCGATAGCGGGTGGGACGATCTGGTACAGCGCGGCG
ATGTCATTCCGGCTACCTCGCCCCACGGGTTGCTCGACGAACCCGCAGGCGACTACGGCGTCGACGGGTCGGCAGCGCTG
GAACAGTTGCGCCGCGAGGAACGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References