Detailed information of TA system TA036407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 3179413..3180079
• Replicon: chromosome
• Accession: NZ_AP022619
• Organism: Mycobacterium paraseoulense strain JCM 16952

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: G6N51_RS14600
• Protein ID: WP_083167403.1
• Coordinates: 3179413..3179886 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: -
• Locus tag: G6N51_RS14605
• Protein ID: WP_083167408.1
• Coordinates: 3179891..3180079 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N51_RS14575	3174827..3176053	+	1227	WP_083167386.1	acetyl-CoA acetyltransferase	-
G6N51_RS14580	3176055..3177569	+	1515	WP_083167389.1	carotenoid oxygenase family protein	-
G6N51_RS14585	3177569..3178051	+	483	WP_083167393.1	VOC family protein	-
G6N51_RS14590	3178057..3178491	-	435	WP_083167397.1	hypothetical protein	-
G6N51_RS14595	3178531..3179328	-	798	WP_083167400.1	VOC family protein	-
G6N51_RS14600	3179413..3179886	-	474	WP_083167403.1	SRPBCC family protein	Toxin
G6N51_RS14605	3179891..3180079	-	189	WP_083167408.1	antitoxin	Antitoxin
G6N51_RS14610	3180148..3182520	-	2373	WP_083167412.1	cation-translocating P-type ATPase	-
G6N51_RS14615	3182517..3184103	-	1587	WP_083167417.1	serine hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17071.67 Da
• Isoelectric Point: 9.8221

>T36407 WP_083167403.1 NZ_AP022619:c3179886-3179413 [Mycobacterium paraseoulense]
MAKLSGSIDVPLPPEVAWKHASDLSRYKDWLTIHRVWRSKLPEDIDKGTIVESIVEVKGMYNRIRWTVVRYKPPEGMTLN
GDGVGGVKVKLLAKVQPAEQGSIVSFDVHLGGPALFGPIGMIVAAALRGDINESLQNFVTVFTRPDPSTNGSGGGHR

Nucleotide

• Length: 474 bp

>T36407 NZ_AP022619:c3179886-3179413 [Mycobacterium paraseoulense]
ATGGCGAAACTCTCCGGATCCATCGACGTCCCGCTGCCACCCGAGGTGGCCTGGAAGCATGCCTCCGACCTGTCCCGGTA
CAAGGACTGGCTGACCATCCACCGGGTGTGGCGCAGCAAACTGCCCGAAGACATCGACAAGGGCACGATCGTGGAGTCGA
TCGTCGAAGTAAAGGGCATGTACAACCGGATCAGGTGGACGGTCGTGCGCTACAAGCCGCCGGAAGGTATGACCCTCAAC
GGCGACGGTGTCGGCGGCGTCAAGGTCAAACTGCTGGCCAAAGTTCAGCCCGCAGAACAGGGCTCCATCGTCAGCTTCGA
CGTCCACCTCGGTGGCCCCGCGCTGTTCGGGCCGATCGGGATGATCGTCGCCGCCGCGCTGCGCGGTGACATCAACGAAT
CGCTGCAGAACTTCGTCACGGTGTTCACCCGGCCCGATCCGAGCACCAACGGGTCCGGCGGCGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6744.42 Da
• Isoelectric Point: 5.0197

>AT36407 WP_083167408.1 NZ_AP022619:c3180079-3179891 [Mycobacterium paraseoulense]
MGFLDKAKELLSQNADKVETAINKAGELVDDKTQGKYSDTIHKVQEQAKKAAESAAQGDHQD

Nucleotide

• Length: 189 bp

>AT36407 NZ_AP022619:c3180079-3179891 [Mycobacterium paraseoulense]
ATGGGATTTCTGGACAAGGCGAAAGAACTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCAATCAACAAGGCCGGCGA
ATTGGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACAAAGTGCAGGAACAAGCCAAGAAGGCGGCCGAAT
CAGCGGCACAAGGCGACCACCAGGACTGA