Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4278997..4279639 Replicon chromosome
Accession NZ_AP022618
Organism Mycolicibacterium insubricum strain JCM 16366

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N16_RS20115 Protein ID WP_083031270.1
Coordinates 4278997..4279434 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N16_RS20120 Protein ID WP_083031272.1
Coordinates 4279448..4279639 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N16_RS20090 4274167..4275669 + 1503 WP_083031263.1 PTS transporter subunit EIIC -
G6N16_RS20095 4275674..4276156 - 483 WP_083031265.1 hypothetical protein -
G6N16_RS20100 4276164..4276550 - 387 WP_083031267.1 phage holin family protein -
G6N16_RS20105 4277105..4277755 + 651 WP_083031282.1 response regulator transcription factor -
G6N16_RS20110 4277748..4278872 + 1125 WP_083031269.1 GAF domain-containing sensor histidine kinase -
G6N16_RS20115 4278997..4279434 - 438 WP_083031270.1 SRPBCC family protein Toxin
G6N16_RS20120 4279448..4279639 - 192 WP_083031272.1 antitoxin Antitoxin
G6N16_RS20125 4279658..4282192 - 2535 WP_083031273.1 HAD-IC family P-type ATPase -
G6N16_RS20130 4282180..4283286 - 1107 WP_083031275.1 MBL fold metallo-hydrolase -
G6N16_RS20135 4283288..4284022 - 735 WP_083031283.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-143)

Antitoxin

Antitoxin Rv0909/MT0933

(4-51)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15526.00 Da        Isoelectric Point: 9.8968

>T36406 WP_083031270.1 NZ_AP022618:c4279434-4278997 [Mycolicibacterium insubricum]
MAKLSVSIDVPLTPEQAWTSASDLSRYSEWLTIHRVWRSALPETLEKGVQLSSIVEVKGMPNRVNWTIVSYKPPMSMTLN
GDGKGGVKIKLIGKVTPTDDGGSNVKFDVHLGGAALFGPIGMVVAGALKGDIRASLEQFKAVFAS

Download         Length: 438 bp

>T36406 NZ_AP022618:c4279434-4278997 [Mycolicibacterium insubricum]
ATGGCAAAGCTTTCCGTCTCCATCGATGTGCCGCTGACCCCCGAGCAGGCCTGGACCAGCGCCTCGGATCTGTCCCGCTA
CTCCGAGTGGCTGACGATTCACCGGGTGTGGCGTTCCGCGCTGCCCGAGACCCTGGAAAAGGGTGTGCAGCTCTCCTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGGTGAACTGGACCATCGTGAGCTACAAGCCGCCGATGTCGATGACCCTCAAC
GGTGACGGCAAGGGCGGGGTGAAGATCAAGCTGATCGGCAAGGTCACCCCCACCGACGACGGCGGCTCCAACGTCAAGTT
CGACGTGCACCTGGGCGGCGCGGCGCTGTTCGGGCCGATCGGCATGGTGGTCGCCGGCGCGCTCAAGGGCGATATCCGTG
CCTCGCTGGAGCAGTTCAAGGCGGTTTTCGCCAGCTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6579.22 Da        Isoelectric Point: 4.3407

>AT36406 WP_083031272.1 NZ_AP022618:c4279639-4279448 [Mycolicibacterium insubricum]
MSFLDKAKDLIGQNVDKVEAAIDKAGDVIDEKTEGKFSGVVDKAQEAAKNFAHNAGDSDAPSA

Download         Length: 192 bp

>AT36406 NZ_AP022618:c4279639-4279448 [Mycolicibacterium insubricum]
ATGTCGTTTCTGGATAAGGCCAAGGATCTGATCGGGCAGAACGTCGACAAGGTCGAGGCCGCGATCGACAAGGCCGGCGA
CGTCATCGACGAGAAGACCGAGGGCAAGTTCTCCGGCGTCGTCGACAAGGCCCAGGAGGCCGCCAAGAACTTCGCGCACA
ACGCCGGCGATTCGGACGCCCCCTCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References