Detailed information of TA system TA036405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3872134..3872801
• Replicon: chromosome
• Accession: NZ_AP022618
• Organism: Mycolicibacterium insubricum strain JCM 16366

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N16_RS18230
• Protein ID: WP_083029110.1
• Coordinates: 3872370..3872801 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N16_RS18225
• Protein ID: WP_083029109.1
• Coordinates: 3872134..3872373 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N16_RS18205	3867330..3868655	-	1326	WP_083029200.1	homoserine dehydrogenase	-
G6N16_RS18210	3868661..3870076	-	1416	WP_083029107.1	diaminopimelate decarboxylase	-
G6N16_RS18215	3870073..3871725	-	1653	WP_083029108.1	arginine--tRNA ligase	-
G6N16_RS18225	3872134..3872373	+	240	WP_083029109.1	ribbon-helix-helix domain-containing protein	Antitoxin
G6N16_RS18230	3872370..3872801	+	432	WP_083029110.1	PIN domain-containing protein	Toxin
G6N16_RS18235	3872844..3873608	-	765	WP_083029111.1	MspA family porin	-
G6N16_RS18240	3873868..3874548	-	681	WP_083029201.1	TenA family protein	-
G6N16_RS18245	3874750..3875034	+	285	WP_083029112.1	hypothetical protein	-
G6N16_RS18250	3875087..3875446	+	360	WP_083029113.1	heme-binding protein	-
G6N16_RS18255	3875520..3877493	+	1974	WP_083029114.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16115.36 Da
• Isoelectric Point: 7.6072

>T36405 WP_083029110.1 NZ_AP022618:3872370-3872801 [Mycolicibacterium insubricum]
VTRALLDVNVLIALFDSDHVDHRRVRQWLDSEIVHGWASCAITQNGFIRIVSQPRYPSPVTPTQAIERLTHATDTVHHEY
WPCSISLLDTKLFDHSKLHGHRQVTDAYLLALATANKARFVTLDQSIALTAVRHAGPQHLTVI

Nucleotide

• Length: 432 bp

>T36405 NZ_AP022618:3872370-3872801 [Mycolicibacterium insubricum]
GTGACACGCGCTCTGCTGGACGTCAACGTTCTGATCGCGCTCTTCGACAGCGATCACGTCGATCACCGGCGCGTTCGCCA
GTGGCTCGACTCCGAGATTGTTCACGGCTGGGCGTCCTGCGCGATAACCCAGAACGGCTTCATCCGCATTGTCAGTCAGC
CTCGGTACCCAAGTCCGGTAACACCGACCCAAGCAATCGAGCGGCTCACCCATGCCACCGATACCGTCCACCACGAGTAC
TGGCCGTGCTCGATCAGTCTGCTCGACACGAAGCTCTTTGACCACTCCAAACTGCACGGCCATCGCCAGGTCACCGATGC
CTATCTGTTGGCGCTCGCGACCGCCAACAAGGCCCGGTTCGTCACCCTCGACCAATCGATCGCCCTGACCGCCGTGCGAC
ATGCCGGTCCCCAGCACCTGACGGTGATCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8669.70 Da
• Isoelectric Point: 5.6939

>AT36405 WP_083029109.1 NZ_AP022618:3872134-3872373 [Mycolicibacterium insubricum]
MRTTLSLDDDVLLAVKERARREKRTAGEVLSDLARQALQQQNAEPGPTAGSFHGFEPFGHRGPAISNALVDKLREEEAV

Nucleotide

• Length: 240 bp

>AT36405 NZ_AP022618:3872134-3872373 [Mycolicibacterium insubricum]
ATGCGCACTACCCTGTCTTTGGACGATGACGTGCTGCTTGCGGTGAAGGAGCGGGCACGCCGGGAGAAGCGCACGGCGGG
CGAGGTGCTTTCCGATCTCGCCCGGCAGGCTTTGCAACAGCAGAACGCCGAGCCGGGGCCAACTGCCGGAAGCTTTCACG
GCTTCGAACCGTTCGGCCACCGCGGACCGGCGATATCGAACGCACTCGTCGACAAGTTGCGCGAGGAAGAAGCCGTGTGA