Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 326416..327076 Replicon chromosome
Accession NZ_AP022618
Organism Mycolicibacterium insubricum strain JCM 16366

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N16_RS01555 Protein ID WP_083033176.1
Coordinates 326416..326808 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N16_RS01560 Protein ID WP_083033185.1
Coordinates 326813..327076 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N16_RS01535 321663..322454 + 792 WP_133052998.1 hypothetical protein -
G6N16_RS01540 322457..324685 - 2229 WP_083033173.1 DNA polymerase III subunits gamma/tau -
G6N16_RS01545 324941..326230 - 1290 WP_083033175.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
G6N16_RS01555 326416..326808 - 393 WP_083033176.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N16_RS01560 326813..327076 - 264 WP_083033185.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N16_RS01570 327317..328108 + 792 WP_083033178.1 hypothetical protein -
G6N16_RS01575 328182..329258 + 1077 WP_083033179.1 dihydrodipicolinate reductase -
G6N16_RS01580 329302..330375 + 1074 WP_083033181.1 S1C family serine protease -
G6N16_RS01585 330896..331591 + 696 WP_163787727.1 peroxiredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-41)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 13795.76 Da        Isoelectric Point: 4.3280

>T36403 WP_083033176.1 NZ_AP022618:c326808-326416 [Mycolicibacterium insubricum]
VAYYFDTSALVKLVVAEPETSALTAWIAEADSDLVSCELTRTELLRAVRRVALDRVVAARAVLDGLALITPSTATFEAAG
HLDPMLFRSLDAVHVATALELGDDLAGMITYDDRMADAARAHGIAVVAPN

Download         Length: 393 bp

>T36403 NZ_AP022618:c326808-326416 [Mycolicibacterium insubricum]
GTGGCCTACTACTTCGACACATCGGCACTGGTCAAGCTGGTCGTCGCCGAGCCGGAAACGAGCGCCCTGACCGCCTGGAT
CGCCGAGGCCGATTCCGATCTCGTCTCCTGCGAACTGACGCGCACCGAACTGCTGCGGGCGGTCCGACGTGTTGCGCTGG
ACCGCGTGGTGGCAGCCCGGGCGGTGCTCGACGGGCTCGCCCTCATCACCCCGAGCACGGCGACGTTCGAGGCGGCGGGT
CACCTCGACCCCATGCTCTTTCGCAGCCTGGACGCCGTGCACGTGGCGACCGCACTGGAACTCGGCGACGACCTGGCCGG
GATGATCACCTACGACGACCGGATGGCCGACGCCGCGCGGGCGCACGGCATCGCGGTGGTTGCGCCGAACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9209.61 Da        Isoelectric Point: 11.1023

>AT36403 WP_083033185.1 NZ_AP022618:c327076-326813 [Mycolicibacterium insubricum]
MTEVGIRALKQNASAVVAEAAAGETIIVTDRGRPVAQLTPLPASPLQRLLASGRARPPRRDIRELPAPSPGPSLTAELAA
MRDAERY

Download         Length: 264 bp

>AT36403 NZ_AP022618:c327076-326813 [Mycolicibacterium insubricum]
ATGACCGAGGTGGGGATCCGGGCCCTCAAACAGAACGCCTCCGCCGTCGTCGCCGAGGCCGCCGCGGGCGAGACGATCAT
CGTCACCGACCGCGGGCGTCCCGTCGCGCAGCTCACCCCGCTGCCCGCCTCGCCGCTGCAGCGCCTGCTGGCCTCGGGCC
GGGCCCGCCCCCCGCGCCGCGACATCCGGGAGCTCCCCGCGCCGAGCCCCGGCCCCAGCCTGACGGCCGAGTTGGCCGCG
ATGCGCGACGCCGAGCGCTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References