36402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3972277..3972938 Replicon chromosome
Accession NZ_AP022617
Organism Mycolicibacterium monacense strain JCM 15658

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0H4V2
Locus tag G6N49_RS19045 Protein ID WP_011854664.1
Coordinates 3972277..3972702 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X0H4R4
Locus tag G6N49_RS19050 Protein ID WP_011854663.1
Coordinates 3972699..3972938 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N49_RS19040 3970379..3972028 - 1650 WP_011854665.1 NERD domain-containing protein/DEAD/DEAH box helicase -
G6N49_RS19045 3972277..3972702 - 426 WP_011854664.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N49_RS19050 3972699..3972938 - 240 WP_011854663.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G6N49_RS19055 3973735..3974079 - 345 WP_041925225.1 hypothetical protein -
G6N49_RS19060 3974367..3974864 - 498 WP_133056645.1 hypothetical protein -
G6N49_RS19065 3975175..3975819 - 645 WP_049771749.1 hypothetical protein -
G6N49_RS19070 3975929..3976504 - 576 WP_041925222.1 hypothetical protein -
G6N49_RS19075 3976636..3977589 - 954 WP_011854658.1 MCE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-127)

Antitoxin

SpoVT-AbrB domain

(9-43)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14905.99 Da        Isoelectric Point: 9.6917

>T36402 WP_011854664.1 NZ_AP022617:c3972702-3972277 [Mycolicibacterium monacense]
MTPVPLTAVDTSVAVPLLVTSHRQHTMVAKWAKARPLGLSGHALAETYSVLTRLPGDARVTAADAVALIDENFPESFQLG
ARAARAAHREFARRGIAGGATYDGLVALAARERGAVLFTRDARARSTYEALGVSTEVLAEP

Download         Length: 426 bp

>T36402 NZ_AP022617:c3972702-3972277 [Mycolicibacterium monacense]
TTGACGCCGGTGCCACTCACGGCGGTCGATACCAGCGTCGCGGTGCCTCTCCTCGTGACCTCGCACCGGCAACACACCAT
GGTCGCGAAGTGGGCGAAGGCGCGGCCGCTTGGGCTCAGCGGACACGCGCTGGCCGAAACATACTCAGTACTCACGCGCC
TGCCTGGCGACGCTCGCGTCACCGCTGCTGACGCGGTCGCATTGATCGACGAGAACTTTCCCGAATCCTTCCAGCTCGGC
GCGCGGGCCGCGCGCGCCGCCCACCGCGAGTTCGCCCGACGGGGAATCGCCGGGGGTGCAACCTATGACGGGCTGGTTGC
CTTGGCGGCTCGTGAGCGCGGTGCCGTGCTGTTCACCCGAGATGCGCGCGCGAGATCGACCTACGAAGCACTCGGGGTGA
GTACCGAAGTGTTGGCCGAACCATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8406.60 Da        Isoelectric Point: 5.7974

>AT36402 WP_011854663.1 NZ_AP022617:c3972938-3972699 [Mycolicibacterium monacense]
MEAVIDSGGRIVLPKQLRDALGLTPGSKVDISAYGGGLHVVPGGRTARLERDEDGRLVARADTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT36402 NZ_AP022617:c3972938-3972699 [Mycolicibacterium monacense]
ATGGAGGCTGTTATCGATTCCGGCGGTCGAATCGTCCTGCCCAAGCAGCTGCGCGATGCGCTGGGTCTGACTCCCGGGTC
CAAGGTCGATATTTCTGCGTACGGCGGCGGACTGCACGTCGTTCCCGGAGGGCGAACCGCTCGACTCGAGCGGGATGAGG
ACGGGCGCCTGGTCGCAAGAGCGGATACGGTCGTCACCGATGAGATGATGTTCGCCCTCATCGATTCGGGACGGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0H4V2

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0H4R4

References