Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2089328..2089956 Replicon chromosome
Accession NZ_AP022617
Organism Mycolicibacterium monacense strain JCM 15658

Toxin (Protein)


Gene name vapC Uniprot ID A0A1X0GQZ4
Locus tag G6N49_RS09930 Protein ID WP_064876250.1
Coordinates 2089546..2089956 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1SYP9
Locus tag G6N49_RS09925 Protein ID WP_064876252.1
Coordinates 2089328..2089555 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N49_RS09895 2084662..2085216 - 555 WP_083045648.1 redoxin domain-containing protein -
G6N49_RS09900 2085209..2085499 - 291 WP_005148657.1 hypothetical protein -
G6N49_RS09905 2085513..2086172 - 660 WP_163647409.1 organomercurial lyase MerB -
G6N49_RS09910 2086199..2087601 - 1403 Protein_1958 mercury(II) reductase -
G6N49_RS09915 2087658..2088045 + 388 Protein_1959 heavy metal-responsive transcriptional regulator -
G6N49_RS09920 2088184..2088825 + 642 WP_079481877.1 cadmium resistance transporter -
G6N49_RS09925 2089328..2089555 + 228 WP_064876252.1 hypothetical protein Antitoxin
G6N49_RS09930 2089546..2089956 + 411 WP_064876250.1 PIN domain nuclease Toxin
G6N49_RS09935 2090198..2090326 - 129 Protein_1963 TlpA family protein disulfide reductase -
G6N49_RS09940 2090394..2090996 - 603 WP_064875957.1 cadmium resistance transporter -
G6N49_RS09945 2090993..2091370 - 378 WP_110807719.1 signal peptidase II -
G6N49_RS09950 2091392..2091790 - 399 WP_179959971.1 metalloregulator ArsR/SmtB family transcription factor -
G6N49_RS09955 2092178..2092819 + 642 WP_064872264.1 TlpA family protein disulfide reductase -
G6N49_RS09960 2092996..2094609 + 1614 WP_099050156.1 apolipoprotein N-acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(12-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14846.02 Da        Isoelectric Point: 4.8950

>T36401 WP_064876250.1 NZ_AP022617:2089546-2089956 [Mycolicibacterium monacense]
VAVTNWIIDKSAYTRLSASRDATAWIERIERGLVRISTVTRLEIGYSFRTGQQAREETASPPLSLMPVEYLTPAAEDRAV
AVQMLLADRGQHRAPAIPDLLVAATAELGGLTVLALDKDFDLIAQVTGQPVESLRM

Download         Length: 411 bp

>T36401 NZ_AP022617:2089546-2089956 [Mycolicibacterium monacense]
GTGGCGGTGACTAATTGGATCATCGACAAATCCGCCTACACACGGCTATCGGCGTCGCGCGACGCCACGGCCTGGATCGA
ACGCATCGAACGCGGCCTCGTCCGCATCAGCACCGTCACCCGACTAGAAATCGGATACTCGTTCCGCACCGGCCAACAGG
CGCGCGAGGAGACAGCATCCCCTCCCCTGAGCCTGATGCCGGTCGAGTACTTGACACCGGCCGCTGAGGACCGCGCCGTC
GCGGTGCAAATGCTGCTGGCCGATCGCGGCCAGCACCGCGCCCCCGCCATTCCTGATCTTCTCGTCGCCGCGACCGCAGA
ACTCGGTGGGCTGACCGTGCTGGCGCTGGACAAGGACTTCGATCTCATCGCCCAGGTCACCGGTCAGCCCGTTGAGAGCC
TGCGGATGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8129.04 Da        Isoelectric Point: 4.7420

>AT36401 WP_064876252.1 NZ_AP022617:2089328-2089555 [Mycolicibacterium monacense]
VSDVLIRGLSEGAVARIDADAAARGLSRQEYLRQRFEREGTVGATQRSLTLADLRRAEAAAADLDDPGVMDTAWR

Download         Length: 228 bp

>AT36401 NZ_AP022617:2089328-2089555 [Mycolicibacterium monacense]
GTGAGCGACGTGCTGATCCGAGGATTGTCCGAGGGGGCGGTGGCGCGCATCGACGCCGACGCGGCCGCGCGCGGCCTGTC
CCGCCAAGAGTATCTGCGTCAGCGGTTCGAGCGCGAAGGGACAGTGGGCGCGACCCAGCGCTCGCTGACGCTGGCCGACC
TGCGCCGCGCTGAGGCCGCCGCCGCCGACCTCGACGATCCCGGCGTGATGGACACAGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0GQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1SYP9

References