Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 1974270..1975255 | Replicon | chromosome |
| Accession | NZ_AP022617 | ||
| Organism | Mycolicibacterium monacense strain JCM 15658 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | A0A1X0H0L6 |
| Locus tag | G6N49_RS09365 | Protein ID | WP_011560054.1 |
| Coordinates | 1974270..1974848 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | A0A1X0H0D6 |
| Locus tag | G6N49_RS09370 | Protein ID | WP_011560053.1 |
| Coordinates | 1974863..1975255 (-) | Length | 131 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| G6N49_RS09345 | 1970328..1971101 | - | 774 | WP_011560058.1 | enoyl-CoA hydratase/isomerase family protein | - |
| G6N49_RS09350 | 1971151..1971513 | - | 363 | WP_011560057.1 | RNA-binding S4 domain-containing protein | - |
| G6N49_RS09355 | 1971523..1972593 | - | 1071 | WP_011855720.1 | aldo/keto reductase | - |
| G6N49_RS09360 | 1972622..1974043 | - | 1422 | WP_011560055.1 | rifampin monooxygenase | - |
| G6N49_RS09365 | 1974270..1974848 | - | 579 | WP_011560054.1 | zeta toxin family protein | Toxin |
| G6N49_RS09370 | 1974863..1975255 | - | 393 | WP_011560053.1 | hypothetical protein | Antitoxin |
| G6N49_RS09375 | 1975364..1976230 | + | 867 | WP_179967744.1 | EamA family transporter | - |
| G6N49_RS09380 | 1976235..1976996 | - | 762 | WP_011560051.1 | SDR family oxidoreductase | - |
| G6N49_RS09385 | 1977007..1978020 | - | 1014 | WP_011768229.1 | acetamidase/formamidase family protein | - |
| G6N49_RS09390 | 1978133..1978540 | + | 408 | WP_011560049.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| G6N49_RS09395 | 1978544..1979176 | - | 633 | WP_041310156.1 | FKBP-type peptidyl-prolyl cis-trans isomerase | - |
| G6N49_RS09405 | 1979325..1980077 | + | 753 | WP_011855719.1 | SDR family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21319.14 Da Isoelectric Point: 8.1325
>T36400 WP_011560054.1 NZ_AP022617:c1974848-1974270 [Mycolicibacterium monacense]
MRRLDLVIGPNGAGKSTFVAFTLAPLLPGSPFVNADEIARQRWPDDAEQHSYEAARIAAATRSALIRSGRSFIAETVFSH
PSKLDLIAEAHGRDYTVVVHVLLVPEDLSVERVRHRVLAGGHRVSEDKIRERYRRLWDLAAQAIESCDSATVYDNSRRRG
PRIVAQFTGGEPIGAPAWPEWTPAPLVQHWPA
MRRLDLVIGPNGAGKSTFVAFTLAPLLPGSPFVNADEIARQRWPDDAEQHSYEAARIAAATRSALIRSGRSFIAETVFSH
PSKLDLIAEAHGRDYTVVVHVLLVPEDLSVERVRHRVLAGGHRVSEDKIRERYRRLWDLAAQAIESCDSATVYDNSRRRG
PRIVAQFTGGEPIGAPAWPEWTPAPLVQHWPA
Download Length: 579 bp
>T36400 NZ_AP022617:c1974848-1974270 [Mycolicibacterium monacense]
ATGCGCCGACTCGACCTCGTCATCGGGCCGAACGGGGCCGGTAAGTCCACCTTCGTCGCGTTCACCCTGGCGCCGCTGCT
GCCGGGCAGCCCGTTCGTCAACGCCGACGAGATCGCCAGGCAGCGCTGGCCCGACGATGCGGAGCAGCACTCCTACGAGG
CGGCCCGGATCGCGGCCGCCACGCGCAGCGCCCTGATCCGTTCGGGTCGCTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCGAAGCTGGACCTCATCGCCGAAGCGCACGGCCGCGACTACACCGTCGTCGTGCACGTCTTGTTGGTCCCCGAGGA
TCTGTCGGTGGAACGCGTGCGGCATCGCGTACTCGCCGGCGGGCACCGCGTCTCGGAGGACAAGATCCGCGAACGATACC
GCCGGCTATGGGATCTCGCGGCTCAGGCGATCGAATCATGTGACAGTGCAACCGTTTACGACAACAGCCGCCGACGCGGA
CCGAGGATCGTGGCCCAGTTCACCGGCGGTGAGCCGATCGGCGCGCCGGCGTGGCCGGAGTGGACACCGGCGCCACTGGT
GCAGCACTGGCCTGCCTGA
ATGCGCCGACTCGACCTCGTCATCGGGCCGAACGGGGCCGGTAAGTCCACCTTCGTCGCGTTCACCCTGGCGCCGCTGCT
GCCGGGCAGCCCGTTCGTCAACGCCGACGAGATCGCCAGGCAGCGCTGGCCCGACGATGCGGAGCAGCACTCCTACGAGG
CGGCCCGGATCGCGGCCGCCACGCGCAGCGCCCTGATCCGTTCGGGTCGCTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCGAAGCTGGACCTCATCGCCGAAGCGCACGGCCGCGACTACACCGTCGTCGTGCACGTCTTGTTGGTCCCCGAGGA
TCTGTCGGTGGAACGCGTGCGGCATCGCGTACTCGCCGGCGGGCACCGCGTCTCGGAGGACAAGATCCGCGAACGATACC
GCCGGCTATGGGATCTCGCGGCTCAGGCGATCGAATCATGTGACAGTGCAACCGTTTACGACAACAGCCGCCGACGCGGA
CCGAGGATCGTGGCCCAGTTCACCGGCGGTGAGCCGATCGGCGCGCCGGCGTGGCCGGAGTGGACACCGGCGCCACTGGT
GCAGCACTGGCCTGCCTGA
Antitoxin
Download Length: 131 a.a. Molecular weight: 13705.22 Da Isoelectric Point: 4.9341
>AT36400 WP_011560053.1 NZ_AP022617:c1975255-1974863 [Mycolicibacterium monacense]
MADVADRVTRVAADLIDSAAVEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGVAGLDTLNREEGVVFNAEI
SAAIEERLAGADYGELLAARGITTVALDDAGRIVQYRPDGTSVVLDDTPA
MADVADRVTRVAADLIDSAAVEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGVAGLDTLNREEGVVFNAEI
SAAIEERLAGADYGELLAARGITTVALDDAGRIVQYRPDGTSVVLDDTPA
Download Length: 393 bp
>AT36400 NZ_AP022617:c1975255-1974863 [Mycolicibacterium monacense]
ATGGCTGACGTCGCCGACCGGGTGACTCGCGTCGCCGCCGATCTGATCGACAGTGCGGCGGTCGAGGGCGCACGCCAGAG
CCGCTCTGCCAAACAGCAACTCGACCACTGGGCGCGGGTCGGCCGGGCGGTGTCGAGTCACCACACCGCCGCCCGCAGGC
GCGTCGAAGCCGCGCTGGCCGGAGTAGCCGGCCTCGACACCCTCAACCGCGAGGAGGGCGTGGTCTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCGGCTCGCCGGCGCCGACTACGGGGAACTGCTGGCGGCCCGCGGCATCACCACCGTCGCCCT
CGACGACGCCGGCCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACCCCGGCCTGA
ATGGCTGACGTCGCCGACCGGGTGACTCGCGTCGCCGCCGATCTGATCGACAGTGCGGCGGTCGAGGGCGCACGCCAGAG
CCGCTCTGCCAAACAGCAACTCGACCACTGGGCGCGGGTCGGCCGGGCGGTGTCGAGTCACCACACCGCCGCCCGCAGGC
GCGTCGAAGCCGCGCTGGCCGGAGTAGCCGGCCTCGACACCCTCAACCGCGAGGAGGGCGTGGTCTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCGGCTCGCCGGCGCCGACTACGGGGAACTGCTGGCGGCCCGCGGCATCACCACCGTCGCCCT
CGACGACGCCGGCCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACCCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X0H0L6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1X0H0D6 |