Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1974270..1975255 Replicon chromosome
Accession NZ_AP022617
Organism Mycolicibacterium monacense strain JCM 15658

Toxin (Protein)


Gene name pezT Uniprot ID A0A1X0H0L6
Locus tag G6N49_RS09365 Protein ID WP_011560054.1
Coordinates 1974270..1974848 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A1X0H0D6
Locus tag G6N49_RS09370 Protein ID WP_011560053.1
Coordinates 1974863..1975255 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N49_RS09345 1970328..1971101 - 774 WP_011560058.1 enoyl-CoA hydratase/isomerase family protein -
G6N49_RS09350 1971151..1971513 - 363 WP_011560057.1 RNA-binding S4 domain-containing protein -
G6N49_RS09355 1971523..1972593 - 1071 WP_011855720.1 aldo/keto reductase -
G6N49_RS09360 1972622..1974043 - 1422 WP_011560055.1 rifampin monooxygenase -
G6N49_RS09365 1974270..1974848 - 579 WP_011560054.1 zeta toxin family protein Toxin
G6N49_RS09370 1974863..1975255 - 393 WP_011560053.1 hypothetical protein Antitoxin
G6N49_RS09375 1975364..1976230 + 867 WP_179967744.1 EamA family transporter -
G6N49_RS09380 1976235..1976996 - 762 WP_011560051.1 SDR family oxidoreductase -
G6N49_RS09385 1977007..1978020 - 1014 WP_011768229.1 acetamidase/formamidase family protein -
G6N49_RS09390 1978133..1978540 + 408 WP_011560049.1 pyridoxamine 5'-phosphate oxidase family protein -
G6N49_RS09395 1978544..1979176 - 633 WP_041310156.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N49_RS09405 1979325..1980077 + 753 WP_011855719.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(6-155)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21319.14 Da        Isoelectric Point: 8.1325

>T36400 WP_011560054.1 NZ_AP022617:c1974848-1974270 [Mycolicibacterium monacense]
MRRLDLVIGPNGAGKSTFVAFTLAPLLPGSPFVNADEIARQRWPDDAEQHSYEAARIAAATRSALIRSGRSFIAETVFSH
PSKLDLIAEAHGRDYTVVVHVLLVPEDLSVERVRHRVLAGGHRVSEDKIRERYRRLWDLAAQAIESCDSATVYDNSRRRG
PRIVAQFTGGEPIGAPAWPEWTPAPLVQHWPA

Download         Length: 579 bp

>T36400 NZ_AP022617:c1974848-1974270 [Mycolicibacterium monacense]
ATGCGCCGACTCGACCTCGTCATCGGGCCGAACGGGGCCGGTAAGTCCACCTTCGTCGCGTTCACCCTGGCGCCGCTGCT
GCCGGGCAGCCCGTTCGTCAACGCCGACGAGATCGCCAGGCAGCGCTGGCCCGACGATGCGGAGCAGCACTCCTACGAGG
CGGCCCGGATCGCGGCCGCCACGCGCAGCGCCCTGATCCGTTCGGGTCGCTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCGAAGCTGGACCTCATCGCCGAAGCGCACGGCCGCGACTACACCGTCGTCGTGCACGTCTTGTTGGTCCCCGAGGA
TCTGTCGGTGGAACGCGTGCGGCATCGCGTACTCGCCGGCGGGCACCGCGTCTCGGAGGACAAGATCCGCGAACGATACC
GCCGGCTATGGGATCTCGCGGCTCAGGCGATCGAATCATGTGACAGTGCAACCGTTTACGACAACAGCCGCCGACGCGGA
CCGAGGATCGTGGCCCAGTTCACCGGCGGTGAGCCGATCGGCGCGCCGGCGTGGCCGGAGTGGACACCGGCGCCACTGGT
GCAGCACTGGCCTGCCTGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13705.22 Da        Isoelectric Point: 4.9341

>AT36400 WP_011560053.1 NZ_AP022617:c1975255-1974863 [Mycolicibacterium monacense]
MADVADRVTRVAADLIDSAAVEGARQSRSAKQQLDHWARVGRAVSSHHTAARRRVEAALAGVAGLDTLNREEGVVFNAEI
SAAIEERLAGADYGELLAARGITTVALDDAGRIVQYRPDGTSVVLDDTPA

Download         Length: 393 bp

>AT36400 NZ_AP022617:c1975255-1974863 [Mycolicibacterium monacense]
ATGGCTGACGTCGCCGACCGGGTGACTCGCGTCGCCGCCGATCTGATCGACAGTGCGGCGGTCGAGGGCGCACGCCAGAG
CCGCTCTGCCAAACAGCAACTCGACCACTGGGCGCGGGTCGGCCGGGCGGTGTCGAGTCACCACACCGCCGCCCGCAGGC
GCGTCGAAGCCGCGCTGGCCGGAGTAGCCGGCCTCGACACCCTCAACCGCGAGGAGGGCGTGGTCTTCAACGCCGAGATC
TCCGCGGCGATCGAGGAGCGGCTCGCCGGCGCCGACTACGGGGAACTGCTGGCGGCCCGCGGCATCACCACCGTCGCCCT
CGACGACGCCGGCCGGATCGTGCAGTACCGGCCCGACGGCACGTCGGTCGTCCTCGACGACACCCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0H0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0H0D6

References