Detailed information of TA system TA036399

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4749089..4749633
• Replicon: chromosome
• Accession: NZ_AP022616
• Organism: Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G6N46_RS22730
• Protein ID: WP_138250677.1
• Coordinates: 4749337..4749633 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: G6N46_RS22725
• Protein ID: WP_073694733.1
• Coordinates: 4749089..4749340 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N46_RS22705	4744975..4746489	+	1515	WP_138250680.1	zinc ribbon domain-containing protein	-
G6N46_RS22710	4746452..4747078	-	627	WP_138250679.1	hypothetical protein	-
G6N46_RS22715	4747075..4748349	-	1275	WP_138250678.1	NADH:flavin oxidoreductase/NADH oxidase family protein	-
G6N46_RS22720	4748441..4749028	+	588	WP_073694734.1	TetR/AcrR family transcriptional regulator	-
G6N46_RS22725	4749089..4749340	+	252	WP_073694733.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G6N46_RS22730	4749337..4749633	+	297	WP_138250677.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N46_RS22735	4749664..4751874	-	2211	WP_138250676.1	AAA family ATPase	-
G6N46_RS22740	4751871..4752761	-	891	WP_073694730.1	CDP-diacylglycerol--serine O-phosphatidyltransferase	-
G6N46_RS22745	4752758..4753486	-	729	WP_073694729.1	phosphatidylserine decarboxylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (4-73)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11402.92 Da
• Isoelectric Point: 6.6350

>T36399 WP_138250677.1 NZ_AP022616:4749337-4749633 [Mycolicibacterium phocaicum]
VSRYVLSPAARADLEDVWDYTCERWNADQAQAYVREIQHAIERIAESPMIGRACDDVRPGYRKHAVGSHVLYYRLISGEI
IDVVRILHQRMDVPRHLD

Nucleotide

• Length: 297 bp

>T36399 NZ_AP022616:4749337-4749633 [Mycolicibacterium phocaicum]
GTGAGCCGTTATGTACTTTCGCCCGCGGCGCGCGCCGACTTGGAAGATGTCTGGGACTACACATGTGAGCGCTGGAACGC
TGATCAGGCGCAGGCGTACGTTCGGGAGATTCAACATGCCATCGAACGCATCGCGGAGTCGCCGATGATCGGGCGAGCGT
GCGACGACGTTCGCCCGGGTTACCGGAAACATGCGGTGGGATCGCACGTGCTGTATTACCGGCTCATCTCCGGGGAAATC
ATCGACGTCGTGCGCATCCTCCATCAGCGGATGGATGTGCCTCGGCACCTTGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9510.36 Da
• Isoelectric Point: 5.7425

>AT36399 WP_073694733.1 NZ_AP022616:4749089-4749340 [Mycolicibacterium phocaicum]
VGRNTSFSLDEHYSAFIETEVASGRYRSASDVVRSALRLLEDRETRLRALRQALVDGERSGESTEFDFDEFVSRKRAEGS
HRQ

Nucleotide

• Length: 252 bp

>AT36399 NZ_AP022616:4749089-4749340 [Mycolicibacterium phocaicum]
GTGGGCAGGAACACCTCATTCAGTCTCGATGAGCACTACAGCGCGTTCATCGAGACTGAAGTCGCGTCCGGTCGTTATCG
ATCGGCCAGTGACGTAGTGCGATCCGCATTGCGACTGCTCGAGGATCGGGAGACTCGACTGAGGGCGTTGCGCCAGGCCC
TTGTGGATGGTGAACGTAGCGGTGAATCAACAGAATTCGACTTTGATGAGTTCGTATCGCGCAAACGGGCCGAGGGTTCC
CATCGTCAGTGA