Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 4749089..4749633 Replicon chromosome
Accession NZ_AP022616
Organism Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag G6N46_RS22730 Protein ID WP_138250677.1
Coordinates 4749337..4749633 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag G6N46_RS22725 Protein ID WP_073694733.1
Coordinates 4749089..4749340 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N46_RS22705 4744975..4746489 + 1515 WP_138250680.1 zinc ribbon domain-containing protein -
G6N46_RS22710 4746452..4747078 - 627 WP_138250679.1 hypothetical protein -
G6N46_RS22715 4747075..4748349 - 1275 WP_138250678.1 NADH:flavin oxidoreductase/NADH oxidase family protein -
G6N46_RS22720 4748441..4749028 + 588 WP_073694734.1 TetR/AcrR family transcriptional regulator -
G6N46_RS22725 4749089..4749340 + 252 WP_073694733.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
G6N46_RS22730 4749337..4749633 + 297 WP_138250677.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N46_RS22735 4749664..4751874 - 2211 WP_138250676.1 AAA family ATPase -
G6N46_RS22740 4751871..4752761 - 891 WP_073694730.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
G6N46_RS22745 4752758..4753486 - 729 WP_073694729.1 phosphatidylserine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(4-73)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11402.92 Da        Isoelectric Point: 6.6350

>T36399 WP_138250677.1 NZ_AP022616:4749337-4749633 [Mycolicibacterium phocaicum]
VSRYVLSPAARADLEDVWDYTCERWNADQAQAYVREIQHAIERIAESPMIGRACDDVRPGYRKHAVGSHVLYYRLISGEI
IDVVRILHQRMDVPRHLD

Download         Length: 297 bp

>T36399 NZ_AP022616:4749337-4749633 [Mycolicibacterium phocaicum]
GTGAGCCGTTATGTACTTTCGCCCGCGGCGCGCGCCGACTTGGAAGATGTCTGGGACTACACATGTGAGCGCTGGAACGC
TGATCAGGCGCAGGCGTACGTTCGGGAGATTCAACATGCCATCGAACGCATCGCGGAGTCGCCGATGATCGGGCGAGCGT
GCGACGACGTTCGCCCGGGTTACCGGAAACATGCGGTGGGATCGCACGTGCTGTATTACCGGCTCATCTCCGGGGAAATC
ATCGACGTCGTGCGCATCCTCCATCAGCGGATGGATGTGCCTCGGCACCTTGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9510.36 Da        Isoelectric Point: 5.7425

>AT36399 WP_073694733.1 NZ_AP022616:4749089-4749340 [Mycolicibacterium phocaicum]
VGRNTSFSLDEHYSAFIETEVASGRYRSASDVVRSALRLLEDRETRLRALRQALVDGERSGESTEFDFDEFVSRKRAEGS
HRQ

Download         Length: 252 bp

>AT36399 NZ_AP022616:4749089-4749340 [Mycolicibacterium phocaicum]
GTGGGCAGGAACACCTCATTCAGTCTCGATGAGCACTACAGCGCGTTCATCGAGACTGAAGTCGCGTCCGGTCGTTATCG
ATCGGCCAGTGACGTAGTGCGATCCGCATTGCGACTGCTCGAGGATCGGGAGACTCGACTGAGGGCGTTGCGCCAGGCCC
TTGTGGATGGTGAACGTAGCGGTGAATCAACAGAATTCGACTTTGATGAGTTCGTATCGCGCAAACGGGCCGAGGGTTCC
CATCGTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References