Detailed information of TA system TA036398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 4122062..4122632
• Replicon: chromosome
• Accession: NZ_AP022616
• Organism: Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: G6N46_RS19710
• Protein ID: WP_082934949.1
• Coordinates: 4122285..4122632 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A7I7ZUA3
• Locus tag: G6N46_RS19705
• Protein ID: WP_064861194.1
• Coordinates: 4122062..4122298 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N46_RS19700	4118636..4121884	-	3249	WP_138251099.1	arabinosyltransferase domain-containing protein	-
G6N46_RS19705	4122062..4122298	+	237	WP_064861194.1	hypothetical protein	Antitoxin
G6N46_RS19710	4122285..4122632	+	348	WP_082934949.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
G6N46_RS19715	4122643..4125840	-	3198	WP_138251098.1	arabinosyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-112)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12064.18 Da
• Isoelectric Point: 11.1786

>T36398 WP_082934949.1 NZ_AP022616:4122285-4122632 [Mycolicibacterium phocaicum]
MTSAEPRRGDLWLVALGAGRAGEPTKHRPAVVLSVDDLLTGEPTELVVVVPVSSSRIATPLRPTIRPGEGVEVDSVAVCR
AVRGIARGRLVRRLGVLAAPTMGQIEKSLALILGI

Nucleotide

• Length: 348 bp

>T36398 NZ_AP022616:4122285-4122632 [Mycolicibacterium phocaicum]
ATGACCTCGGCTGAGCCACGCCGCGGTGACTTATGGCTGGTCGCACTCGGTGCCGGTCGGGCCGGAGAACCGACGAAACA
CCGGCCCGCCGTTGTGCTGTCTGTTGATGATCTGCTCACCGGTGAACCCACCGAACTTGTCGTGGTGGTTCCCGTCTCCA
GCTCGCGAATCGCCACACCTCTGCGGCCCACAATCCGGCCGGGCGAGGGCGTCGAGGTGGACAGCGTCGCCGTCTGCCGC
GCCGTCCGTGGCATCGCCCGGGGTCGGCTGGTACGTCGGCTCGGGGTGCTCGCGGCACCAACGATGGGACAGATAGAGAA
ATCCCTGGCCCTGATCCTCGGTATATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8538.25 Da
• Isoelectric Point: 4.0717

>AT36398 WP_064861194.1 NZ_AP022616:4122062-4122298 [Mycolicibacterium phocaicum]
MATPTTTIRVPVATRDRLNARARDHGISVVALLDEWANRAEREDAFAAERAATVAEATNEAVIEEDQDWGQTDTDDLG

Nucleotide

• Length: 237 bp

>AT36398 NZ_AP022616:4122062-4122298 [Mycolicibacterium phocaicum]
ATGGCGACACCGACGACGACAATCCGGGTCCCGGTCGCGACCCGTGACCGCCTCAACGCACGAGCTCGCGACCACGGTAT
TTCCGTTGTCGCGTTGCTCGACGAATGGGCCAACCGCGCAGAACGCGAGGATGCGTTTGCAGCGGAGCGGGCTGCCACCG
TGGCCGAGGCGACCAACGAAGCCGTCATCGAAGAGGACCAGGACTGGGGCCAGACGGACACCGATGACCTCGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I7ZUA3