Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1576164..1576825 Replicon chromosome
Accession NZ_AP022616
Organism Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R5W8S0
Locus tag G6N46_RS07645 Protein ID WP_061001017.1
Coordinates 1576400..1576825 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R5W7M0
Locus tag G6N46_RS07640 Protein ID WP_061001016.1
Coordinates 1576164..1576403 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N46_RS07630 1574000..1574626 - 627 WP_061001014.1 DUF4194 domain-containing protein -
G6N46_RS07635 1574608..1576062 - 1455 WP_061001015.1 DUF3375 domain-containing protein -
G6N46_RS07640 1576164..1576403 + 240 WP_061001016.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
G6N46_RS07645 1576400..1576825 + 426 WP_061001017.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N46_RS07650 1577087..1577563 - 477 WP_064860476.1 DIP1984 family protein -
G6N46_RS07655 1577682..1577966 - 285 WP_061001018.1 hypothetical protein -
G6N46_RS07660 1577982..1578203 - 222 WP_138248766.1 hypothetical protein -
G6N46_RS07665 1578284..1578909 - 626 Protein_1523 dihydrofolate reductase family protein -
G6N46_RS07670 1578988..1580262 - 1275 WP_133428395.1 hypothetical protein -
G6N46_RS07675 1580272..1581153 - 882 WP_061001021.1 class A beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-126)

Antitoxin

SpoVT-AbrB domain

(4-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14535.33 Da        Isoelectric Point: 5.8813

>T36396 WP_061001017.1 NZ_AP022616:1576400-1576825 [Mycolicibacterium phocaicum]
MTSQQVTAIDTSVAVPLLVSSHPQHVAVSQWAMGRRLGLSGHALAETYSVLTRLPGDARVDPADAVALIDDNFPEPLQLG
ADTGRGAHHEFARCGVAGGATYDGLVALAAREHGAVLVTRDARAKATYDALGVNAEVLAGA

Download         Length: 426 bp

>T36396 NZ_AP022616:1576400-1576825 [Mycolicibacterium phocaicum]
CTGACGTCGCAGCAGGTCACGGCAATCGATACCAGCGTCGCGGTGCCCTTGCTTGTGTCCTCGCATCCGCAGCACGTCGC
GGTCTCGCAATGGGCAATGGGCCGACGTCTTGGGCTCAGCGGGCATGCGCTGGCCGAGACATACTCGGTTCTGACGCGTC
TGCCCGGCGATGCTCGTGTCGACCCTGCCGACGCGGTGGCGTTGATCGACGACAACTTCCCGGAGCCCCTTCAACTGGGT
GCCGACACGGGACGCGGTGCCCATCACGAATTCGCCCGTTGTGGCGTCGCGGGCGGCGCCACCTATGACGGCTTGGTCGC
GTTGGCCGCTCGTGAGCACGGTGCAGTCCTGGTCACTCGCGATGCCAGAGCCAAGGCAACCTACGACGCCCTCGGGGTAA
ACGCGGAAGTGCTGGCCGGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8336.60 Da        Isoelectric Point: 8.7166

>AT36396 WP_061001016.1 NZ_AP022616:1576164-1576403 [Mycolicibacterium phocaicum]
MEAVIDSGGRILVPKQLRDALGLTPGSTVDISAYGPGLQIVPGGRSARLVRNKDGRLVANADTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT36396 NZ_AP022616:1576164-1576403 [Mycolicibacterium phocaicum]
ATGGAAGCGGTAATCGACTCGGGCGGCCGCATCTTGGTGCCCAAGCAACTCCGCGACGCGTTGGGACTGACGCCCGGTTC
GACGGTCGATATTTCGGCATATGGCCCTGGACTGCAGATTGTCCCCGGCGGCCGCTCCGCGCGCCTCGTGCGAAACAAGG
ACGGACGCCTCGTCGCCAACGCAGACACAGTCGTCACCGATGAAATGATGTTCGCGCTCATCGATTCGGGGCGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R5W8S0

Antitoxin

Source ID Structure
AlphaFold DB A0A4R5W7M0

References