Detailed information of TA system TA036395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1569013..1569614
• Replicon: chromosome
• Accession: NZ_AP022616
• Organism: Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N46_RS07615
• Protein ID: WP_133425924.1
• Coordinates: 1569213..1569614 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N46_RS07610
• Protein ID: WP_133425925.1
• Coordinates: 1569013..1569216 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N46_RS07595	1564303..1565583	+	1281	WP_138248770.1	BREX system ATP-binding protein BrxD	-
G6N46_RS07600	1565580..1567667	+	2088	WP_138248769.1	DEAD/DEAH box helicase	-
G6N46_RS07605	1567850..1568365	+	516	WP_138248768.1	RNA methyltransferase	-
G6N46_RS07610	1569013..1569216	+	204	WP_133425925.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
G6N46_RS07615	1569213..1569614	+	402	WP_133425924.1	PIN domain nuclease	Toxin
G6N46_RS07620	1569597..1570736	-	1140	WP_138248767.1	hypothetical protein	-
G6N46_RS07625	1570729..1574007	-	3279	WP_061001013.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-120)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-41)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14814.98 Da
• Isoelectric Point: 6.0803

>T36395 WP_133425924.1 NZ_AP022616:1569213-1569614 [Mycolicibacterium phocaicum]
MILVDTSAWIEFLRNTGSGVCVRVDELLAEPIAICAPVQMEILAGARNDRHLKDLRGLLARAQTLPTSPTDYEDAATIYR
VCRRRGETVRRLIDCLIAAHAIREQIPILHSDGDFDAIARHTSLQLDTSPRPD

Nucleotide

• Length: 402 bp

>T36395 NZ_AP022616:1569213-1569614 [Mycolicibacterium phocaicum]
ATGATCCTCGTTGACACGTCAGCCTGGATCGAGTTTCTAAGGAACACCGGGAGCGGTGTGTGCGTGCGAGTCGACGAGCT
ACTCGCCGAGCCGATCGCGATCTGCGCTCCCGTCCAGATGGAAATCCTCGCCGGGGCCCGAAACGACCGCCACCTCAAGG
ATCTTCGTGGCCTGTTGGCACGCGCACAAACTCTACCGACATCCCCCACTGACTATGAAGACGCCGCAACCATTTACCGC
GTCTGTCGGCGTCGCGGTGAAACCGTACGCAGGCTGATCGACTGCCTCATCGCCGCGCACGCCATACGCGAACAGATTCC
AATCCTGCACTCCGACGGCGACTTCGACGCAATTGCGCGGCATACATCACTACAGCTGGATACCTCACCGCGGCCGGACT
GA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7754.72 Da
• Isoelectric Point: 6.4577

>AT36395 WP_133425925.1 NZ_AP022616:1569013-1569216 [Mycolicibacterium phocaicum]
MTRTNIDIDDHACEVVMRRFHLTSKRDAVNFALRNLAQEALDLKAARELRGSGWDADLDELRSDRVR

Nucleotide

• Length: 204 bp

>AT36395 NZ_AP022616:1569013-1569216 [Mycolicibacterium phocaicum]
ATGACCCGCACAAACATCGACATCGACGACCATGCGTGCGAGGTCGTCATGCGAAGGTTCCATTTGACCAGCAAGCGAGA
CGCGGTGAACTTCGCGTTGCGCAATCTCGCCCAGGAAGCATTGGACCTCAAAGCGGCCCGAGAACTCCGCGGGTCCGGAT
GGGACGCCGATCTCGATGAATTGCGCAGCGACCGCGTCCGATGA