Detailed information of TA system TA036393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 741999..742972
• Replicon: chromosome
• Accession: NZ_AP022616
• Organism: Mycolicibacterium phocaicum strain JCM 15301

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N46_RS03620
• Protein ID: WP_138249312.1
• Coordinates: 741999..742574 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: A0A7I7ZJ01
• Locus tag: G6N46_RS03625
• Protein ID: WP_064859148.1
• Coordinates: 742571..742972 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N46_RS03595	737733..738524	-	792	WP_138249316.1	SDR family NAD(P)-dependent oxidoreductase	-
G6N46_RS03600	738587..739183	-	597	WP_135356222.1	TetR family transcriptional regulator	-
G6N46_RS03605	739219..739530	-	312	WP_135356223.1	NIPSNAP family protein	-
G6N46_RS03610	740273..740824	-	552	WP_138249315.1	sugar O-acetyltransferase	-
G6N46_RS03615	740938..741489	-	552	WP_138249314.1	YaeQ family protein	-
G6N46_RS03620	741999..742574	-	576	WP_138249312.1	zeta toxin family protein	Toxin
G6N46_RS03625	742571..742972	-	402	WP_064859148.1	hypothetical protein	Antitoxin
G6N46_RS28235	743082..743228	+	147	WP_135356159.1	hypothetical protein	-
G6N46_RS03630	744202..744411	+	210	WP_138250388.1	hypothetical protein	-
G6N46_RS03635	744392..745325	-	934	Protein_722	IS3 family transposase	-
G6N46_RS03640	745322..745612	-	291	WP_103850853.1	transposase	-
G6N46_RS03645	745740..746456	+	717	WP_138250389.1	hypothetical protein	-
G6N46_RS03650	746479..747069	-	591	WP_138250390.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	736420..748037	11617

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 20975.94 Da
• Isoelectric Point: 8.5172

>T36393 WP_138249312.1 NZ_AP022616:c742574-741999 [Mycolicibacterium phocaicum]
VKRLDLVVGSNGAGKSTFVELTLAPLLPSSVFVNADEIAKQRWPTDALGHAYEAARIAAATREALIEQGRSFIAETVFSH
PSKLELIDAAHHAGYVVVLHIVLIPENLAVHRVRYRVAAGGHDVPEEKIRERYRRLWTLVAAAIVRVDSATIYDNSAASG
PQIVAQMSGGLSVDTPRWPSWTPEQLRSRWP

Nucleotide

• Length: 576 bp

>T36393 NZ_AP022616:c742574-741999 [Mycolicibacterium phocaicum]
GTGAAACGCCTGGACCTCGTCGTCGGCTCGAACGGTGCCGGAAAATCGACGTTCGTCGAACTCACGCTGGCTCCGCTGCT
ACCGAGCAGCGTGTTCGTCAACGCGGATGAGATCGCCAAGCAGCGCTGGCCTACCGACGCTTTGGGCCACGCCTACGAGG
CCGCGCGGATCGCCGCGGCGACGCGGGAAGCGTTGATCGAGCAGGGGCGTTCATTCATCGCCGAGACTGTGTTCTCGCAC
CCCTCCAAGCTGGAGCTGATCGATGCGGCCCATCATGCGGGGTACGTCGTGGTGTTGCACATTGTGCTGATTCCGGAGAA
CTTGGCCGTTCACCGCGTCCGCTACCGGGTTGCCGCCGGTGGCCACGATGTGCCCGAGGAGAAGATCCGGGAACGGTATC
GCCGGCTGTGGACGTTGGTGGCTGCAGCGATCGTTCGCGTCGACAGCGCAACGATTTACGACAATTCCGCGGCCAGCGGA
CCGCAGATCGTCGCGCAGATGAGTGGCGGGCTGAGTGTCGACACGCCCCGATGGCCGTCGTGGACTCCGGAACAGCTGCG
TAGTCGCTGGCCGTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14178.66 Da
• Isoelectric Point: 5.2217

>AT36393 WP_064859148.1 NZ_AP022616:c742972-742571 [Mycolicibacterium phocaicum]
MSDVADRVTRVSADLFEAAAAEGARQSRSAKQQLDHWARVGRAVSTQHTASRRRVEAALAGQIDIAVLNTEEGVVFNAEV
SAAIEESLARTDYGAVLASRGITTVALDEDGQIVEHRPDGTESVVGAVHSLRR

Nucleotide

• Length: 402 bp

>AT36393 NZ_AP022616:c742972-742571 [Mycolicibacterium phocaicum]
ATGTCCGACGTCGCCGATCGGGTCACCCGGGTGTCCGCTGACCTGTTCGAGGCCGCGGCCGCCGAGGGTGCCCGGCAGAG
TCGCTCCGCCAAGCAGCAACTCGACCATTGGGCGCGGGTGGGCCGCGCTGTATCGACCCAGCACACCGCTTCACGACGCA
GGGTGGAGGCTGCCCTCGCCGGTCAGATCGACATCGCCGTTCTTAACACCGAAGAAGGCGTGGTGTTCAATGCGGAGGTT
TCCGCGGCGATCGAGGAGAGTCTGGCCCGCACCGATTACGGTGCCGTGCTCGCCTCTCGTGGGATCACCACGGTGGCATT
GGATGAGGACGGCCAGATCGTCGAGCATCGCCCGGACGGCACCGAGTCCGTGGTTGGTGCGGTGCACTCGCTGCGTCGGT
GA

Structures

Antitoxin

• AlphaFold DB: A0A7I7ZJ01