Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4998389..4999056 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N25_RS23185 Protein ID WP_083075166.1
Coordinates 4998389..4998820 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N25_RS23190 Protein ID WP_083075168.1
Coordinates 4998817..4999056 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N25_RS23165 4994592..4995827 - 1236 WP_083075161.1 hypothetical protein -
G6N25_RS23170 4996452..4996831 - 380 Protein_4580 TetR/AcrR family transcriptional regulator -
G6N25_RS23175 4997489..4997716 + 228 WP_083075162.1 antitoxin -
G6N25_RS23180 4997713..4998102 + 390 WP_083075164.1 PIN domain-containing protein -
G6N25_RS23185 4998389..4998820 - 432 WP_083075166.1 PIN domain-containing protein Toxin
G6N25_RS23190 4998817..4999056 - 240 WP_083075168.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N25_RS23195 4999567..4999797 + 231 WP_083075170.1 antitoxin -
G6N25_RS23200 4999784..5000131 + 348 WP_083075171.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N25_RS23205 5000339..5001148 - 810 WP_083075173.1 sulfotransferase -
G6N25_RS23210 5001433..5001681 + 249 WP_083075175.1 hypothetical protein -
G6N25_RS23215 5001766..5002959 - 1194 WP_083075176.1 PPE family protein -
G6N25_RS23220 5002974..5003273 - 300 WP_083075178.1 PE family protein -
G6N25_RS23225 5003502..5003696 + 195 WP_142272736.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4972893..5016520 43627
- flank IS/Tn - - 4992700..4994289 1589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15934.05 Da        Isoelectric Point: 6.2101

>T36391 WP_083075166.1 NZ_AP022615:c4998820-4998389 [Mycobacterium heidelbergense]
VTRALLDVNVLIALLDSDHVDHERVRGWIDAEIVHGWASCAITQNGFARIVSQPRYPSPVPPAQAIARLARAAATEYHEY
WTCSVSLLDDELFDYTRLHGHRQVTDAYLLALATANGCRFATLDQTIPIDAVRRADARNLTLI

Download         Length: 432 bp

>T36391 NZ_AP022615:c4998820-4998389 [Mycobacterium heidelbergense]
GTGACGCGCGCCCTGCTGGACGTCAATGTCCTCATTGCGCTGCTTGACAGCGATCACGTCGATCACGAGCGTGTTCGTGG
GTGGATCGACGCCGAGATCGTCCACGGCTGGGCGTCGTGTGCGATAACTCAGAACGGCTTCGCTCGGATCGTCAGCCAGC
CTCGATACCCCAGCCCGGTGCCACCTGCACAGGCAATCGCCAGGTTGGCTCGCGCCGCGGCGACCGAGTATCACGAGTAC
TGGACATGTTCGGTCAGTCTGCTCGACGACGAGCTTTTCGACTACACGCGGCTGCACGGACATCGTCAGGTGACCGACGC
ATATCTACTCGCGCTCGCAACCGCCAACGGCTGCCGGTTCGCGACTCTGGATCAGACGATTCCCATCGACGCTGTCCGGC
GCGCCGATGCGCGCAACCTGACGCTTATCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8893.88 Da        Isoelectric Point: 4.8096

>AT36391 WP_083075168.1 NZ_AP022615:c4999056-4998817 [Mycobacterium heidelbergense]
MRTTLSLDDDVLLAVKERARRENRTAGEVLSDLARQALTQQCQTGTPTRESFYGFEPFEHRGAAVSNALIDRLRDEEAV

Download         Length: 240 bp

>AT36391 NZ_AP022615:c4999056-4998817 [Mycobacterium heidelbergense]
ATGCGCACCACGCTGTCCTTGGATGATGACGTATTGCTCGCGGTGAAGGAACGCGCGCGCCGCGAGAACCGCACAGCAGG
CGAAGTTCTGTCCGATCTCGCGCGGCAGGCGCTGACACAACAGTGCCAGACCGGCACGCCCACACGGGAAAGCTTCTACG
GTTTCGAACCCTTCGAGCATCGAGGGGCTGCCGTGTCCAACGCTCTCATCGACCGGCTGCGTGACGAGGAAGCCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References