Detailed information of TA system TA036389

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 4702304..4702806
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6N25_RS21980
• Protein ID: WP_083074058.1
• Coordinates: 4702304..4702558 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6N25_RS21985
• Protein ID: WP_083074122.1
• Coordinates: 4702555..4702806 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS21955	4697531..4699321	-	1791	WP_083074061.1	cytochrome c oxidase assembly protein	-
G6N25_RS21960	4699325..4700035	-	711	WP_083074060.1	zf-HC2 domain-containing protein	-
G6N25_RS21965	4700206..4700937	-	732	WP_083074059.1	RES domain-containing protein	-
G6N25_RS21970	4700952..4701341	-	390	WP_083074124.1	hypothetical protein	-
G6N25_RS21975	4701560..4702240	+	681	WP_142272628.1	glycoside hydrolase	-
G6N25_RS21980	4702304..4702558	-	255	WP_083074058.1	Txe/YoeB family addiction module toxin	Toxin
G6N25_RS21985	4702555..4702806	-	252	WP_083074122.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G6N25_RS21990	4703037..4704473	+	1437	WP_083074057.1	type I glutamate--ammonia ligase	-
G6N25_RS21995	4704490..4705773	-	1284	WP_083074056.1	HipA domain-containing protein	-
G6N25_RS22000	4705754..4706107	-	354	WP_083074055.1	helix-turn-helix domain-containing protein	-
G6N25_RS22005	4706429..4706665	+	237	WP_083074121.1	hypothetical protein	-
G6N25_RS22010	4706662..4707039	+	378	WP_083074054.1	type II toxin-antitoxin system HicB family antitoxin	-
G6N25_RS22015	4707036..4707392	+	357	WP_083074053.1	DUF732 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4678288..4747230	68942

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9793.11 Da
• Isoelectric Point: 8.8899

>T36389 WP_083074058.1 NZ_AP022615:c4702558-4702304 [Mycobacterium heidelbergense]
VNIVSAPQAWEDYTHWQTTDRAILKRINKLISEACRSPNEGIGKPEPLKYGLSGAWSRRITEEHRLVYRVVGEDLQILQA
RYHY

Nucleotide

• Length: 255 bp

>T36389 NZ_AP022615:c4702558-4702304 [Mycobacterium heidelbergense]
GTGAACATCGTCTCTGCGCCTCAGGCGTGGGAGGACTACACGCACTGGCAGACCACTGATCGGGCGATTCTCAAACGGAT
CAACAAGCTCATCAGCGAGGCTTGCCGTTCGCCTAACGAAGGCATTGGCAAGCCTGAGCCACTGAAGTATGGGCTCTCGG
GGGCGTGGTCGCGCCGTATCACCGAGGAGCACCGCTTGGTGTACCGGGTCGTGGGTGAGGATTTGCAGATCCTCCAGGCG
AGGTATCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9290.40 Da
• Isoelectric Point: 4.8411

>AT36389 WP_083074122.1 NZ_AP022615:c4702806-4702555 [Mycobacterium heidelbergense]
MAITASEARKNLFPLIEKVNADRTPVEITSKAGRAFLVAADDWEAWQETAYLFRSPENARRLLDAAAALDEGRGRRTDLD
RAE

Nucleotide

• Length: 252 bp

>AT36389 NZ_AP022615:c4702806-4702555 [Mycobacterium heidelbergense]
ATGGCAATCACAGCCAGTGAGGCGCGAAAGAACCTGTTTCCGTTGATCGAAAAAGTCAACGCTGACCGGACTCCGGTAGA
GATCACCTCCAAGGCCGGCCGGGCATTCCTTGTCGCCGCCGACGACTGGGAGGCGTGGCAGGAAACCGCTTATCTGTTCC
GTTCGCCGGAAAACGCGCGTCGGCTTCTCGATGCCGCCGCCGCCCTTGACGAAGGTCGGGGTAGGCGGACCGATCTAGAC
CGGGCGGAGTGA