Detailed information of TA system TA036387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 4053446..4054107
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS18985
• Protein ID: WP_158084880.1
• Coordinates: 4053446..4053880 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS18990
• Protein ID: WP_197745683.1
• Coordinates: 4053877..4054107 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS18960	4049646..4050461	-	816	WP_083074394.1	DUF2236 domain-containing protein	-
G6N25_RS18965	4050514..4051497	+	984	WP_083074393.1	cobalamin biosynthesis protein	-
G6N25_RS18970	4051479..4052285	-	807	WP_083074392.1	SURF1 family protein	-
G6N25_RS18975	4052285..4052776	-	492	WP_083074391.1	low molecular weight phosphotyrosine protein phosphatase	-
G6N25_RS18980	4052769..4053458	-	690	WP_083074390.1	HAD-IA family hydrolase	-
G6N25_RS18985	4053446..4053880	-	435	WP_158084880.1	PIN domain-containing protein	Toxin
G6N25_RS18990	4053877..4054107	-	231	WP_197745683.1	ribbon-helix-helix protein, CopG family	Antitoxin
G6N25_RS18995	4054241..4055272	+	1032	WP_083074389.1	threonine-phosphate decarboxylase	-
G6N25_RS19000	4055269..4056411	+	1143	WP_083074388.1	Nif3-like dinuclear metal center hexameric protein	-
G6N25_RS19005	4056408..4057145	+	738	WP_083074387.1	zinc ribbon domain-containing protein	-
G6N25_RS19010	4057142..4058224	+	1083	WP_083074386.1	bifunctional RNase H/acid phosphatase	-
G6N25_RS19015	4058355..4058885	+	531	WP_163672481.1	TetR/AcrR family transcriptional regulator C-terminal ligand-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endonuclease VapC20-like (3-134)

Antitoxin

• Ribbon-helix-helix protein, CopG (4-32)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 16457.42 Da
• Isoelectric Point: 6.2472

>T36387 WP_158084880.1 NZ_AP022615:c4053880-4053446 [Mycobacterium heidelbergense]
VKFADTGWWVAWALPGDARHSDALAMLGAVGRSEQILTTNLVAGETWTFLRRKDSHRTALAFLDRLDALSSAERLVVHRV
SEDQEAAAWDWLRKDDERVYSFVDATSFRVMRDRRLREALAFDRDFAAAGFVEVRASRQGQWES

Nucleotide

• Length: 435 bp

>T36387 NZ_AP022615:c4053880-4053446 [Mycobacterium heidelbergense]
GTGAAATTCGCTGACACGGGTTGGTGGGTGGCATGGGCGCTGCCCGGGGATGCTCGGCACAGCGACGCGCTCGCCATGCT
CGGGGCGGTGGGGCGGTCTGAGCAAATCCTCACAACCAACCTCGTTGCCGGCGAGACCTGGACGTTTCTGCGCCGAAAAG
ACAGCCACCGGACCGCGCTGGCCTTTCTCGACCGGCTCGATGCTCTGAGCAGCGCCGAACGCCTCGTCGTGCACCGGGTT
AGCGAGGACCAAGAAGCCGCAGCCTGGGACTGGCTCCGTAAGGACGATGAGCGGGTGTATTCCTTTGTCGACGCGACAAG
TTTTCGCGTCATGCGCGACCGGCGTCTGCGCGAGGCTTTAGCTTTCGACCGGGACTTCGCGGCGGCCGGATTCGTGGAGG
TCCGGGCCAGCCGTCAGGGACAATGGGAATCGTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8045.19 Da
• Isoelectric Point: 4.5203

>AT36387 WP_197745683.1 NZ_AP022615:c4054107-4053877 [Mycobacterium heidelbergense]
VKTVTITLPEELDALAAAEARRRGISKSELIRLGLGAVLSPPLGEPKDDLWRSLAGFGSARVSVEPGEIDDVIYGT

Nucleotide

• Length: 231 bp

>AT36387 NZ_AP022615:c4054107-4053877 [Mycobacterium heidelbergense]
GTGAAGACCGTCACGATCACGCTCCCCGAAGAACTCGACGCGCTGGCCGCCGCCGAAGCACGCCGACGTGGCATTTCCAA
GTCAGAGCTGATACGGCTGGGACTCGGTGCCGTCCTTTCGCCGCCGCTCGGCGAGCCCAAGGACGACCTTTGGCGTTCGC
TTGCCGGATTCGGCTCCGCCCGTGTCTCGGTGGAACCGGGCGAGATCGACGATGTCATCTATGGCACGTGA