Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3608719..3609359 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N25_RS17030 Protein ID WP_083077343.1
Coordinates 3608940..3609359 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N25_RS17025 Protein ID WP_083010950.1
Coordinates 3608719..3608943 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N25_RS16995 3604057..3604326 + 270 WP_083077340.1 hypothetical protein -
G6N25_RS17000 3604570..3604740 - 171 WP_158084940.1 hypothetical protein -
G6N25_RS17005 3605518..3606702 + 1185 WP_142272878.1 hypothetical protein -
G6N25_RS17010 3606799..3607004 - 206 Protein_3366 alcohol dehydrogenase -
G6N25_RS17015 3607086..3607937 - 852 WP_179961677.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
G6N25_RS17020 3607934..3608491 - 558 WP_083077353.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
G6N25_RS17025 3608719..3608943 + 225 WP_083010950.1 antitoxin Antitoxin
G6N25_RS17030 3608940..3609359 + 420 WP_083077343.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N25_RS17035 3609504..3610160 - 657 WP_142272879.1 RES domain-containing protein -
G6N25_RS17040 3610161..3610499 - 339 WP_083077346.1 hypothetical protein -
G6N25_RS17045 3612175..3613101 + 927 WP_142272880.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3601171..3615314 14143


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-138)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14815.81 Da        Isoelectric Point: 6.7539

>T36385 WP_083077343.1 NZ_AP022615:3608940-3609359 [Mycobacterium heidelbergense]
VTALLDVNVLIALSWRNHAHHSAAREWFTRSSSNGWATTPITEVGFVRISSDRRVVQVSTTPATALAQLEALRALPGHAF
WPDDVPLVVGEGGDRGAVSSHRLVTDCHLIALVARYGGRLVTFDAALADSAPAGLVEVL

Download         Length: 420 bp

>T36385 NZ_AP022615:3608940-3609359 [Mycobacterium heidelbergense]
GTGACAGCGCTGCTCGACGTCAATGTGCTTATCGCGTTGAGCTGGCGTAACCATGCTCATCACTCAGCGGCACGGGAGTG
GTTCACGCGGTCTTCGTCGAATGGATGGGCTACCACGCCGATCACCGAGGTGGGTTTTGTCCGGATTTCGAGCGATCGCA
GGGTGGTGCAGGTGTCGACGACTCCGGCGACTGCGCTTGCTCAGTTGGAAGCGCTGAGAGCTCTTCCGGGCCATGCGTTC
TGGCCTGATGACGTGCCGTTGGTGGTTGGTGAGGGGGGTGATCGTGGTGCTGTGTCGAGCCACCGCCTTGTCACTGACTG
TCATCTCATCGCGTTGGTCGCCCGGTACGGTGGCCGGCTGGTCACATTCGACGCTGCACTGGCCGATTCAGCACCCGCCG
GCCTGGTCGAGGTTCTGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7986.02 Da        Isoelectric Point: 3.9937

>AT36385 WP_083010950.1 NZ_AP022615:3608719-3608943 [Mycobacterium heidelbergense]
MRTTLQIDDDILEDARSIARSEGRSVGAVISDLARRSLRPVGIVVVDGLPMFDVPPDAPIIADEDVARGLEEDV

Download         Length: 225 bp

>AT36385 NZ_AP022615:3608719-3608943 [Mycobacterium heidelbergense]
ATGCGCACCACTCTTCAAATCGATGACGATATCCTCGAAGATGCGCGGAGCATCGCTCGTTCGGAGGGCCGGTCGGTCGG
TGCGGTGATTTCCGATCTGGCGCGTCGGTCGCTTCGGCCCGTCGGGATTGTCGTGGTCGACGGGCTCCCGATGTTCGATG
TGCCGCCAGATGCGCCAATCATCGCCGACGAGGACGTCGCCCGGGGGCTCGAGGAAGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References