Detailed information of TA system TA036385

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 3608719..3609359
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS17030
• Protein ID: WP_083077343.1
• Coordinates: 3608940..3609359 (+)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS17025
• Protein ID: WP_083010950.1
• Coordinates: 3608719..3608943 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS16995	3604057..3604326	+	270	WP_083077340.1	hypothetical protein	-
G6N25_RS17000	3604570..3604740	-	171	WP_158084940.1	hypothetical protein	-
G6N25_RS17005	3605518..3606702	+	1185	WP_142272878.1	hypothetical protein	-
G6N25_RS17010	3606799..3607004	-	206	Protein_3366	alcohol dehydrogenase	-
G6N25_RS17015	3607086..3607937	-	852	WP_179961677.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
G6N25_RS17020	3607934..3608491	-	558	WP_083077353.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
G6N25_RS17025	3608719..3608943	+	225	WP_083010950.1	antitoxin	Antitoxin
G6N25_RS17030	3608940..3609359	+	420	WP_083077343.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N25_RS17035	3609504..3610160	-	657	WP_142272879.1	RES domain-containing protein	-
G6N25_RS17040	3610161..3610499	-	339	WP_083077346.1	hypothetical protein	-
G6N25_RS17045	3612175..3613101	+	927	WP_142272880.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3601171..3615314	14143

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-138)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14815.81 Da
• Isoelectric Point: 6.7539

>T36385 WP_083077343.1 NZ_AP022615:3608940-3609359 [Mycobacterium heidelbergense]
VTALLDVNVLIALSWRNHAHHSAAREWFTRSSSNGWATTPITEVGFVRISSDRRVVQVSTTPATALAQLEALRALPGHAF
WPDDVPLVVGEGGDRGAVSSHRLVTDCHLIALVARYGGRLVTFDAALADSAPAGLVEVL

Nucleotide

• Length: 420 bp

>T36385 NZ_AP022615:3608940-3609359 [Mycobacterium heidelbergense]
GTGACAGCGCTGCTCGACGTCAATGTGCTTATCGCGTTGAGCTGGCGTAACCATGCTCATCACTCAGCGGCACGGGAGTG
GTTCACGCGGTCTTCGTCGAATGGATGGGCTACCACGCCGATCACCGAGGTGGGTTTTGTCCGGATTTCGAGCGATCGCA
GGGTGGTGCAGGTGTCGACGACTCCGGCGACTGCGCTTGCTCAGTTGGAAGCGCTGAGAGCTCTTCCGGGCCATGCGTTC
TGGCCTGATGACGTGCCGTTGGTGGTTGGTGAGGGGGGTGATCGTGGTGCTGTGTCGAGCCACCGCCTTGTCACTGACTG
TCATCTCATCGCGTTGGTCGCCCGGTACGGTGGCCGGCTGGTCACATTCGACGCTGCACTGGCCGATTCAGCACCCGCCG
GCCTGGTCGAGGTTCTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7986.02 Da
• Isoelectric Point: 3.9937

>AT36385 WP_083010950.1 NZ_AP022615:3608719-3608943 [Mycobacterium heidelbergense]
MRTTLQIDDDILEDARSIARSEGRSVGAVISDLARRSLRPVGIVVVDGLPMFDVPPDAPIIADEDVARGLEEDV

Nucleotide

• Length: 225 bp

>AT36385 NZ_AP022615:3608719-3608943 [Mycobacterium heidelbergense]
ATGCGCACCACTCTTCAAATCGATGACGATATCCTCGAAGATGCGCGGAGCATCGCTCGTTCGGAGGGCCGGTCGGTCGG
TGCGGTGATTTCCGATCTGGCGCGTCGGTCGCTTCGGCCCGTCGGGATTGTCGTGGTCGACGGGCTCCCGATGTTCGATG
TGCCGCCAGATGCGCCAATCATCGCCGACGAGGACGTCGCCCGGGGGCTCGAGGAAGACGTGTGA