Detailed information of TA system TA036384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 2968171..2968826
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS14080
• Protein ID: WP_179961672.1
• Coordinates: 2968171..2968569 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS14085
• Protein ID: WP_083075605.1
• Coordinates: 2968566..2968826 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS14065	2965047..2966255	-	1209	WP_083075600.1	FAD-dependent monooxygenase	-
G6N25_RS14070	2966336..2966872	+	537	WP_083075602.1	TetR/AcrR family transcriptional regulator	-
G6N25_RS14075	2966972..2967961	+	990	WP_083075603.1	LLM class F420-dependent oxidoreductase	-
G6N25_RS14080	2968171..2968569	-	399	WP_179961672.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N25_RS14085	2968566..2968826	-	261	WP_083075605.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
G6N25_RS14090	2968885..2969580	-	696	WP_083075638.1	hypothetical protein	-
G6N25_RS14095	2971090..2972154	+	1065	WP_083075606.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-122)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14050.06 Da
• Isoelectric Point: 4.8059

>T36384 WP_179961672.1 NZ_AP022615:c2968569-2968171 [Mycobacterium heidelbergense]
VTSTGVLDTSVFIAQESGRRLNASRFPDEVATTVVTVAELNLGVLAAASSDVRAQRLATLDAIADIFAFPVDDVAARMWA
RLRIHLAETGHRVRINDLWIAAIAASRGLPVVTQDADFDALDGVAGLIIVRV

Nucleotide

• Length: 399 bp

>T36384 NZ_AP022615:c2968569-2968171 [Mycobacterium heidelbergense]
GTGACCTCCACCGGCGTGCTCGACACATCAGTATTCATCGCACAGGAAAGCGGTCGCCGCCTCAATGCATCACGGTTTCC
TGACGAAGTGGCGACCACCGTGGTCACAGTGGCCGAACTCAACCTTGGCGTACTCGCAGCCGCCTCGTCGGACGTTCGTG
CGCAACGACTGGCAACCCTGGACGCGATTGCCGACATATTCGCATTTCCGGTCGATGACGTCGCAGCGCGTATGTGGGCG
CGACTTCGAATCCACCTGGCAGAGACCGGCCACCGAGTCCGCATCAATGACCTTTGGATCGCGGCCATCGCGGCTTCTCG
GGGACTGCCGGTGGTTACGCAAGACGCTGACTTCGATGCGCTCGACGGAGTCGCCGGTTTGATCATTGTGCGCGTCTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9347.64 Da
• Isoelectric Point: 5.0789

>AT36384 WP_083075605.1 NZ_AP022615:c2968826-2968566 [Mycobacterium heidelbergense]
MAVAASRELRNDTAGLLRRVQAGEDITVTVNGKAVALLTALQPTRCRWLGRDELLRRLDRAQADPALRQELAELAGDTTD
DLGPLP

Nucleotide

• Length: 261 bp

>AT36384 NZ_AP022615:c2968826-2968566 [Mycobacterium heidelbergense]
ATGGCTGTAGCGGCTTCCCGAGAACTGCGCAATGACACCGCCGGGCTACTACGGCGCGTCCAGGCGGGCGAAGACATCAC
CGTCACCGTCAACGGCAAGGCGGTCGCCCTTCTCACCGCTCTGCAGCCGACCCGGTGCAGATGGCTAGGCCGAGACGAAC
TGCTACGGAGGCTTGACCGCGCGCAAGCGGATCCTGCGTTGCGTCAGGAACTCGCTGAGCTGGCAGGCGACACCACCGAC
GACCTTGGGCCGCTTCCGTGA