Detailed information of TA system TA036382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1850883..1851728
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: G6N25_RS08730
• Protein ID: WP_083076655.1
• Coordinates: 1850883..1851416 (-)
• Length: 178 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: G6N25_RS08735
• Protein ID: WP_083076698.1
• Coordinates: 1851426..1851728 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS08705	1846103..1847080	-	978	WP_083076675.1	zinc-binding dehydrogenase	-
G6N25_RS08710	1847082..1848293	-	1212	WP_083076671.1	cytochrome P450	-
G6N25_RS08715	1848290..1848994	-	705	WP_083076667.1	NIPSNAP family protein	-
G6N25_RS08720	1848998..1849546	-	549	WP_083076663.1	hypothetical protein	-
G6N25_RS08725	1849680..1850849	-	1170	WP_083076659.1	CoA transferase	-
G6N25_RS08730	1850883..1851416	-	534	WP_083076655.1	GNAT family N-acetyltransferase	Toxin
G6N25_RS08735	1851426..1851728	-	303	WP_083076698.1	DUF1778 domain-containing protein	Antitoxin
G6N25_RS08740	1851979..1853102	-	1124	Protein_1736	PE family protein	-
G6N25_RS08745	1853367..1854044	+	678	WP_083076652.1	DUF427 domain-containing protein	-
G6N25_RS08750	1854117..1855037	-	921	WP_083076649.1	LLM class F420-dependent oxidoreductase	-
G6N25_RS08755	1855053..1855934	-	882	WP_083076645.1	thioesterase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1817347..1861163	43816

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (32-119)

Antitoxin

• Vibrio phage ICP1, Orf50 (16-92)

Sequences

Toxin

Protein

• Length: 178 a.a.
• Molecular weight: 19394.06 Da
• Isoelectric Point: 7.0625

>T36382 WP_083076655.1 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
MTEGGQAKPGEPEKLAKAHDRTGFESGAAELDEWLKKYSWQNQRANNATTYVSTFDGRVVGYYAITVAGYARGTAPEAVA
KKAPETVPCFLLARLAVDLEWQGRGLGWGLLRDAMRRVLLLSRSVAAPALLVHARDDTARAFSLHHAEFLESPVDPLHLF
LPMKAIASFLSADHDFA

Nucleotide

• Length: 534 bp

>T36382 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
TTGACGGAAGGCGGCCAAGCAAAGCCGGGCGAGCCGGAGAAACTTGCCAAAGCTCACGATCGGACCGGCTTCGAGTCAGG
TGCGGCCGAACTCGACGAGTGGCTCAAGAAGTACAGCTGGCAGAACCAACGCGCCAACAACGCGACCACCTACGTCAGTA
CCTTCGACGGTCGCGTTGTTGGCTACTACGCGATCACGGTCGCGGGCTACGCACGGGGCACTGCTCCCGAAGCGGTTGCA
AAGAAGGCCCCCGAAACGGTCCCGTGCTTTCTGCTGGCCCGGCTGGCCGTCGATCTCGAATGGCAGGGCCGTGGCCTGGG
CTGGGGTTTGTTGCGCGACGCGATGCGGCGAGTCCTCCTGTTATCGAGATCGGTGGCAGCGCCCGCCCTGTTGGTCCATG
CTCGCGACGACACCGCTCGCGCGTTCTCTCTCCATCACGCCGAGTTCCTGGAATCACCGGTCGATCCGCTTCATCTTTTC
TTGCCGATGAAGGCGATTGCCAGCTTCTTGTCGGCAGATCACGATTTCGCGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11458.85 Da
• Isoelectric Point: 4.8723

>AT36382 WP_083076698.1 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
MGNTDAATTKTARDQRLNFRVSAQQQQLIRQAAEATESTVTDFILDSVLESAERVLADRRWFVASEEQWAKFQALLDAPL
EPMPKLHRLLQRESPFAERD

Nucleotide

• Length: 303 bp

>AT36382 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
ATGGGCAACACCGACGCCGCCACCACCAAAACCGCTCGCGACCAGCGCTTGAATTTCCGAGTCAGCGCCCAGCAGCAGCA
GCTGATACGTCAGGCCGCAGAAGCGACAGAAAGCACGGTTACGGACTTCATTCTGGACAGCGTCTTGGAGAGCGCCGAGC
GGGTTCTTGCCGATCGCAGATGGTTCGTCGCCAGCGAAGAACAGTGGGCAAAGTTCCAGGCCCTGCTGGACGCTCCGCTA
GAGCCGATGCCCAAACTTCATCGACTTCTGCAGCGCGAGAGTCCATTCGCCGAGCGCGATTGA