Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1850883..1851728 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag G6N25_RS08730 Protein ID WP_083076655.1
Coordinates 1850883..1851416 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag G6N25_RS08735 Protein ID WP_083076698.1
Coordinates 1851426..1851728 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N25_RS08705 1846103..1847080 - 978 WP_083076675.1 zinc-binding dehydrogenase -
G6N25_RS08710 1847082..1848293 - 1212 WP_083076671.1 cytochrome P450 -
G6N25_RS08715 1848290..1848994 - 705 WP_083076667.1 NIPSNAP family protein -
G6N25_RS08720 1848998..1849546 - 549 WP_083076663.1 hypothetical protein -
G6N25_RS08725 1849680..1850849 - 1170 WP_083076659.1 CoA transferase -
G6N25_RS08730 1850883..1851416 - 534 WP_083076655.1 GNAT family N-acetyltransferase Toxin
G6N25_RS08735 1851426..1851728 - 303 WP_083076698.1 DUF1778 domain-containing protein Antitoxin
G6N25_RS08740 1851979..1853102 - 1124 Protein_1736 PE family protein -
G6N25_RS08745 1853367..1854044 + 678 WP_083076652.1 DUF427 domain-containing protein -
G6N25_RS08750 1854117..1855037 - 921 WP_083076649.1 LLM class F420-dependent oxidoreductase -
G6N25_RS08755 1855053..1855934 - 882 WP_083076645.1 thioesterase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1817347..1861163 43816


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-119)

Antitoxin

Vibrio phage ICP1, Orf50

(16-92)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19394.06 Da        Isoelectric Point: 7.0625

>T36382 WP_083076655.1 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
MTEGGQAKPGEPEKLAKAHDRTGFESGAAELDEWLKKYSWQNQRANNATTYVSTFDGRVVGYYAITVAGYARGTAPEAVA
KKAPETVPCFLLARLAVDLEWQGRGLGWGLLRDAMRRVLLLSRSVAAPALLVHARDDTARAFSLHHAEFLESPVDPLHLF
LPMKAIASFLSADHDFA

Download         Length: 534 bp

>T36382 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
TTGACGGAAGGCGGCCAAGCAAAGCCGGGCGAGCCGGAGAAACTTGCCAAAGCTCACGATCGGACCGGCTTCGAGTCAGG
TGCGGCCGAACTCGACGAGTGGCTCAAGAAGTACAGCTGGCAGAACCAACGCGCCAACAACGCGACCACCTACGTCAGTA
CCTTCGACGGTCGCGTTGTTGGCTACTACGCGATCACGGTCGCGGGCTACGCACGGGGCACTGCTCCCGAAGCGGTTGCA
AAGAAGGCCCCCGAAACGGTCCCGTGCTTTCTGCTGGCCCGGCTGGCCGTCGATCTCGAATGGCAGGGCCGTGGCCTGGG
CTGGGGTTTGTTGCGCGACGCGATGCGGCGAGTCCTCCTGTTATCGAGATCGGTGGCAGCGCCCGCCCTGTTGGTCCATG
CTCGCGACGACACCGCTCGCGCGTTCTCTCTCCATCACGCCGAGTTCCTGGAATCACCGGTCGATCCGCTTCATCTTTTC
TTGCCGATGAAGGCGATTGCCAGCTTCTTGTCGGCAGATCACGATTTCGCGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11458.85 Da        Isoelectric Point: 4.8723

>AT36382 WP_083076698.1 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
MGNTDAATTKTARDQRLNFRVSAQQQQLIRQAAEATESTVTDFILDSVLESAERVLADRRWFVASEEQWAKFQALLDAPL
EPMPKLHRLLQRESPFAERD

Download         Length: 303 bp

>AT36382 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
ATGGGCAACACCGACGCCGCCACCACCAAAACCGCTCGCGACCAGCGCTTGAATTTCCGAGTCAGCGCCCAGCAGCAGCA
GCTGATACGTCAGGCCGCAGAAGCGACAGAAAGCACGGTTACGGACTTCATTCTGGACAGCGTCTTGGAGAGCGCCGAGC
GGGTTCTTGCCGATCGCAGATGGTTCGTCGCCAGCGAAGAACAGTGGGCAAAGTTCCAGGCCCTGCTGGACGCTCCGCTA
GAGCCGATGCCCAAACTTCATCGACTTCTGCAGCGCGAGAGTCCATTCGCCGAGCGCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References