Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1850883..1851728 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag G6N25_RS08730 Protein ID WP_083076655.1
Coordinates 1850883..1851416 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag G6N25_RS08735 Protein ID WP_083076698.1
Coordinates 1851426..1851728 (-) Length 101 a.a.

Genomic Context

G6N25_RS08745G6N25_RS08705G6N25_RS08710G6N25_RS08715G6N25_RS08720G6N25_RS08725G6N25_RS08730G6N25_RS08735G6N25_RS08740G6N25_RS08750G6N25_RS08755
Location: 1853367..1854044 (678 bp)
Type: Others
Protein ID: WP_083076652.1
Location: 1846103..1847080 (978 bp)
Type: Others
Protein ID: WP_083076675.1
Location: 1847082..1848293 (1212 bp)
Type: Others
Protein ID: WP_083076671.1
Location: 1848290..1848994 (705 bp)
Type: Others
Protein ID: WP_083076667.1
Location: 1848998..1849546 (549 bp)
Type: Others
Protein ID: WP_083076663.1
Location: 1849680..1850849 (1170 bp)
Type: Others
Protein ID: WP_083076659.1
Location: 1850883..1851416 (534 bp)
Type: Toxin
Protein ID: WP_083076655.1
Location: 1851426..1851728 (303 bp)
Type: Antitoxin
Protein ID: WP_083076698.1
Location: 1851979..1853102 (1124 bp)
Type: Others
Protein ID: Protein_1736
Location: 1854117..1855037 (921 bp)
Type: Others
Protein ID: WP_083076649.1
Location: 1855053..1855934 (882 bp)
Type: Others
Protein ID: WP_083076645.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N25_RS087051846103..1847080-978WP_083076675.1zinc-binding dehydrogenase-
G6N25_RS087101847082..1848293-1212WP_083076671.1cytochrome P450-
G6N25_RS087151848290..1848994-705WP_083076667.1NIPSNAP family protein-
G6N25_RS087201848998..1849546-549WP_083076663.1hypothetical protein-
G6N25_RS087251849680..1850849-1170WP_083076659.1CoA transferase-
G6N25_RS087301850883..1851416-534WP_083076655.1GNAT family N-acetyltransferaseToxin
G6N25_RS087351851426..1851728-303WP_083076698.1DUF1778 domain-containing proteinAntitoxin
G6N25_RS087401851979..1853102-1124Protein_1736PE family protein-
G6N25_RS087451853367..1854044+678WP_083076652.1DUF427 domain-containing protein-
G6N25_RS087501854117..1855037-921WP_083076649.1LLM class F420-dependent oxidoreductase-
G6N25_RS087551855053..1855934-882WP_083076645.1thioesterase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1817347..186116343816


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-119)

Antitoxin

Vibrio phage ICP1, Orf50

(16-92)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19394.06 Da        Isoelectric Point: 7.0625

>T36382 WP_083076655.1 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
MTEGGQAKPGEPEKLAKAHDRTGFESGAAELDEWLKKYSWQNQRANNATTYVSTFDGRVVGYYAITVAGYARGTAPEAVA
KKAPETVPCFLLARLAVDLEWQGRGLGWGLLRDAMRRVLLLSRSVAAPALLVHARDDTARAFSLHHAEFLESPVDPLHLF
LPMKAIASFLSADHDFA

Download         Length: 534 bp

>T36382 NZ_AP022615:c1851416-1850883 [Mycobacterium heidelbergense]
TTGACGGAAGGCGGCCAAGCAAAGCCGGGCGAGCCGGAGAAACTTGCCAAAGCTCACGATCGGACCGGCTTCGAGTCAGG
TGCGGCCGAACTCGACGAGTGGCTCAAGAAGTACAGCTGGCAGAACCAACGCGCCAACAACGCGACCACCTACGTCAGTA
CCTTCGACGGTCGCGTTGTTGGCTACTACGCGATCACGGTCGCGGGCTACGCACGGGGCACTGCTCCCGAAGCGGTTGCA
AAGAAGGCCCCCGAAACGGTCCCGTGCTTTCTGCTGGCCCGGCTGGCCGTCGATCTCGAATGGCAGGGCCGTGGCCTGGG
CTGGGGTTTGTTGCGCGACGCGATGCGGCGAGTCCTCCTGTTATCGAGATCGGTGGCAGCGCCCGCCCTGTTGGTCCATG
CTCGCGACGACACCGCTCGCGCGTTCTCTCTCCATCACGCCGAGTTCCTGGAATCACCGGTCGATCCGCTTCATCTTTTC
TTGCCGATGAAGGCGATTGCCAGCTTCTTGTCGGCAGATCACGATTTCGCGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11458.85 Da        Isoelectric Point: 4.8723

>AT36382 WP_083076698.1 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
MGNTDAATTKTARDQRLNFRVSAQQQQLIRQAAEATESTVTDFILDSVLESAERVLADRRWFVASEEQWAKFQALLDAPL
EPMPKLHRLLQRESPFAERD

Download         Length: 303 bp

>AT36382 NZ_AP022615:c1851728-1851426 [Mycobacterium heidelbergense]
ATGGGCAACACCGACGCCGCCACCACCAAAACCGCTCGCGACCAGCGCTTGAATTTCCGAGTCAGCGCCCAGCAGCAGCA
GCTGATACGTCAGGCCGCAGAAGCGACAGAAAGCACGGTTACGGACTTCATTCTGGACAGCGTCTTGGAGAGCGCCGAGC
GGGTTCTTGCCGATCGCAGATGGTTCGTCGCCAGCGAAGAACAGTGGGCAAAGTTCCAGGCCCTGCTGGACGCTCCGCTA
GAGCCGATGCCCAAACTTCATCGACTTCTGCAGCGCGAGAGTCCATTCGCCGAGCGCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References