Detailed information of TA system TA036380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1424282..1424977
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS06845
• Protein ID: WP_083076716.1
• Coordinates: 1424552..1424977 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS06840
• Protein ID: WP_083076714.1
• Coordinates: 1424282..1424542 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS06820	1419674..1419952	-	279	WP_083076705.1	putative holin	-
G6N25_RS06825	1419972..1420487	-	516	WP_083076708.1	DUF779 domain-containing protein	-
G6N25_RS06830	1420487..1422022	-	1536	WP_083076710.1	aldehyde dehydrogenase	-
G6N25_RS06835	1422081..1424192	+	2112	WP_083076712.1	prolyl oligopeptidase family protein	-
G6N25_RS06840	1424282..1424542	+	261	WP_083076714.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
G6N25_RS06845	1424552..1424977	+	426	WP_083076716.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N25_RS06850	1425009..1425923	+	915	WP_083076718.1	crotonase/enoyl-CoA hydratase family protein	-
G6N25_RS06855	1425989..1426453	+	465	WP_083076720.1	DUF5078 domain-containing protein	-
G6N25_RS06860	1426731..1427075	+	345	WP_083076775.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15148.31 Da
• Isoelectric Point: 5.1016

>T36380 WP_083076716.1 NZ_AP022615:1424552-1424977 [Mycobacterium heidelbergense]
MIIDTSAVLALIQDEQPHAVEVVAALAGARDPVMSAPTVAECLIVLTARHGPVARTIFERLRTEIDLDIADFTNEHAAAA
QRAFLRYGKGRHPAALNFGDCMTYAAAQISHQPLLAVGNDFPRTDLEFNGGVIGYWPIPAA

Nucleotide

• Length: 426 bp

>T36380 NZ_AP022615:1424552-1424977 [Mycobacterium heidelbergense]
ATGATCATCGACACCAGCGCCGTCCTGGCGCTCATTCAAGACGAGCAGCCGCACGCCGTAGAGGTCGTCGCGGCCCTGGC
CGGCGCGCGTGACCCGGTGATGTCGGCGCCGACCGTCGCGGAATGTCTGATCGTCTTGACCGCCCGCCATGGGCCCGTCG
CGCGCACCATCTTTGAGCGTCTTCGCACCGAAATCGACTTGGATATAGCGGATTTCACCAACGAACATGCAGCCGCCGCG
CAACGCGCGTTCTTGCGGTACGGCAAGGGCCGCCATCCTGCAGCCCTCAACTTCGGCGACTGCATGACCTACGCCGCGGC
CCAAATCAGCCACCAACCGCTCCTGGCGGTCGGCAACGACTTCCCGCGCACCGACCTCGAGTTCAACGGTGGCGTCATCG
GCTACTGGCCGATCCCAGCTGCTTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9813.28 Da
• Isoelectric Point: 6.2259

>AT36380 WP_083076714.1 NZ_AP022615:1424282-1424542 [Mycobacterium heidelbergense]
MALNIKDPEVDRLATELAARLHTNKTGAIRHALNAQLALLQAHAGYREERLLDIMRTEIWPLLTDRTPVTKREREEILGY
DPEIGV

Nucleotide

• Length: 261 bp

>AT36380 NZ_AP022615:1424282-1424542 [Mycobacterium heidelbergense]
ATGGCTCTGAATATCAAGGACCCCGAGGTCGACCGGCTAGCCACGGAGCTCGCCGCCCGCCTTCACACCAACAAGACCGG
CGCCATTCGCCATGCCCTCAACGCCCAACTGGCGCTACTGCAAGCGCACGCCGGCTACCGCGAGGAGCGGCTCCTCGACA
TCATGCGCACCGAAATATGGCCGCTGCTCACCGACCGCACCCCCGTGACCAAACGTGAACGCGAGGAAATCCTGGGCTAC
GACCCCGAGATCGGAGTGTGA