Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1424282..1424977 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N25_RS06845 Protein ID WP_083076716.1
Coordinates 1424552..1424977 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N25_RS06840 Protein ID WP_083076714.1
Coordinates 1424282..1424542 (+) Length 87 a.a.

Genomic Context


G6N25_RS06835G6N25_RS06840G6N25_RS06845G6N25_RS06850G6N25_RS06855G6N25_RS06860G6N25_RS06820G6N25_RS06825G6N25_RS06830
Location: 1422081..1424192 (2112 bp)
Type: Others
Protein ID: WP_083076712.1
Location: 1424282..1424542 (261 bp)
Type: Antitoxin
Protein ID: WP_083076714.1
Location: 1424552..1424977 (426 bp)
Type: Toxin
Protein ID: WP_083076716.1
Location: 1425009..1425923 (915 bp)
Type: Others
Protein ID: WP_083076718.1
Location: 1425989..1426453 (465 bp)
Type: Others
Protein ID: WP_083076720.1
Location: 1426731..1427075 (345 bp)
Type: Others
Protein ID: WP_083076775.1
Location: 1419674..1419952 (279 bp)
Type: Others
Protein ID: WP_083076705.1
Location: 1419972..1420487 (516 bp)
Type: Others
Protein ID: WP_083076708.1
Location: 1420487..1422022 (1536 bp)
Type: Others
Protein ID: WP_083076710.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N25_RS068201419674..1419952-279WP_083076705.1putative holin-
G6N25_RS068251419972..1420487-516WP_083076708.1DUF779 domain-containing protein-
G6N25_RS068301420487..1422022-1536WP_083076710.1aldehyde dehydrogenase-
G6N25_RS068351422081..1424192+2112WP_083076712.1prolyl oligopeptidase family protein-
G6N25_RS068401424282..1424542+261WP_083076714.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
G6N25_RS068451424552..1424977+426WP_083076716.1type II toxin-antitoxin system VapC family toxinToxin
G6N25_RS068501425009..1425923+915WP_083076718.1crotonase/enoyl-CoA hydratase family protein-
G6N25_RS068551425989..1426453+465WP_083076720.1DUF5078 domain-containing protein-
G6N25_RS068601426731..1427075+345WP_083076775.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-125)

Antitoxin

(1-82)


Sequences


Toxin        


Download         Length: 142 a.a.        Molecular weight: 15148.31 Da        Isoelectric Point: 5.1016

>T36380 WP_083076716.1 NZ_AP022615:1424552-1424977 [Mycobacterium heidelbergense]
MIIDTSAVLALIQDEQPHAVEVVAALAGARDPVMSAPTVAECLIVLTARHGPVARTIFERLRTEIDLDIADFTNEHAAAA
QRAFLRYGKGRHPAALNFGDCMTYAAAQISHQPLLAVGNDFPRTDLEFNGGVIGYWPIPAA

Download         Length: 426 bp

>T36380 NZ_AP022615:1424552-1424977 [Mycobacterium heidelbergense]
ATGATCATCGACACCAGCGCCGTCCTGGCGCTCATTCAAGACGAGCAGCCGCACGCCGTAGAGGTCGTCGCGGCCCTGGC
CGGCGCGCGTGACCCGGTGATGTCGGCGCCGACCGTCGCGGAATGTCTGATCGTCTTGACCGCCCGCCATGGGCCCGTCG
CGCGCACCATCTTTGAGCGTCTTCGCACCGAAATCGACTTGGATATAGCGGATTTCACCAACGAACATGCAGCCGCCGCG
CAACGCGCGTTCTTGCGGTACGGCAAGGGCCGCCATCCTGCAGCCCTCAACTTCGGCGACTGCATGACCTACGCCGCGGC
CCAAATCAGCCACCAACCGCTCCTGGCGGTCGGCAACGACTTCCCGCGCACCGACCTCGAGTTCAACGGTGGCGTCATCG
GCTACTGGCCGATCCCAGCTGCTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9813.28 Da        Isoelectric Point: 6.2259

>AT36380 WP_083076714.1 NZ_AP022615:1424282-1424542 [Mycobacterium heidelbergense]
MALNIKDPEVDRLATELAARLHTNKTGAIRHALNAQLALLQAHAGYREERLLDIMRTEIWPLLTDRTPVTKREREEILGY
DPEIGV

Download         Length: 261 bp

>AT36380 NZ_AP022615:1424282-1424542 [Mycobacterium heidelbergense]
ATGGCTCTGAATATCAAGGACCCCGAGGTCGACCGGCTAGCCACGGAGCTCGCCGCCCGCCTTCACACCAACAAGACCGG
CGCCATTCGCCATGCCCTCAACGCCCAACTGGCGCTACTGCAAGCGCACGCCGGCTACCGCGAGGAGCGGCTCCTCGACA
TCATGCGCACCGAAATATGGCCGCTGCTCACCGACCGCACCCCCGTGACCAAACGTGAACGCGAGGAAATCCTGGGCTAC
GACCCCGAGATCGGAGTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
No matching records found

References