Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1296700..1297346 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N25_RS06195 Protein ID WP_083074035.1
Coordinates 1296700..1297092 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N25_RS06200 Protein ID WP_083074012.1
Coordinates 1297089..1297346 (-) Length 86 a.a.

Genomic Context

G6N25_RS06185G6N25_RS06190G6N25_RS06215G6N25_RS06180G6N25_RS06195G6N25_RS06200G6N25_RS06205G6N25_RS06210
Location: 1295743..1296138 (396 bp)
Type: Others
Protein ID: WP_083074010.1
Location: 1296135..1296713 (579 bp)
Type: Others
Protein ID: WP_083074011.1
Location: 1299866..1302238 (2373 bp)
Type: Others
Protein ID: WP_083074014.1
Location: 1293201..1294322 (1122 bp)
Type: Others
Protein ID: WP_142272621.1
Location: 1296700..1297092 (393 bp)
Type: Toxin
Protein ID: WP_083074035.1
Location: 1297089..1297346 (258 bp)
Type: Antitoxin
Protein ID: WP_083074012.1
Location: 1297825..1298766 (942 bp)
Type: Others
Protein ID: WP_083074013.1
Location: 1298769..1299710 (942 bp)
Type: Others
Protein ID: WP_083074036.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N25_RS061801293201..1294322-1122WP_142272621.1hypothetical protein-
G6N25_RS061851295743..1296138+396WP_083074010.1DUF1778 domain-containing protein-
G6N25_RS061901296135..1296713+579WP_083074011.1GNAT family N-acetyltransferase-
G6N25_RS061951296700..1297092-393WP_083074035.1type II toxin-antitoxin system VapC family toxinToxin
G6N25_RS062001297089..1297346-258WP_083074012.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
G6N25_RS062051297825..1298766-942WP_083074013.1class I SAM-dependent methyltransferase-
G6N25_RS062101298769..1299710-942WP_083074036.1class I SAM-dependent methyltransferase-
G6N25_RS062151299866..1302238+2373WP_083074014.1flippase-like domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-50)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14104.01 Da        Isoelectric Point: 4.4978

>T36379 WP_083074035.1 NZ_AP022615:c1297092-1296700 [Mycobacterium heidelbergense]
VTVRRALADTSIFIGIEAARFDDDRFTEYEWGVSVITLGELRLGVLQASGPDTAARRLSTYQLAQRFEPLSIDETVSEAW
ALLVSKLRAANLRAPINDSWIAATAVAHGIPIVTQGSDYSAMPGVEVITI

Download         Length: 393 bp

>T36379 NZ_AP022615:c1297092-1296700 [Mycobacterium heidelbergense]
GTGACGGTTCGGCGGGCCCTCGCCGACACGTCCATCTTCATCGGGATCGAGGCGGCACGATTCGACGACGACCGATTTAC
CGAATACGAATGGGGCGTCTCGGTGATCACACTGGGTGAGCTGCGGCTGGGTGTCCTGCAAGCCAGTGGCCCGGACACCG
CCGCACGCCGGCTCTCCACATACCAGCTTGCTCAGCGGTTCGAACCACTGAGCATCGACGAGACGGTCTCCGAAGCGTGG
GCATTGCTGGTATCCAAGCTGCGCGCCGCCAACCTGCGAGCACCGATCAACGACAGTTGGATTGCGGCAACTGCCGTGGC
GCATGGCATTCCGATCGTGACCCAGGGCAGCGACTACTCTGCGATGCCAGGCGTTGAGGTCATAACAATCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9590.95 Da        Isoelectric Point: 4.8279

>AT36379 WP_083074012.1 NZ_AP022615:c1297346-1297089 [Mycobacterium heidelbergense]
MAATIPARDLRNRTAEVLRRVAAGEEIEVLKDNRPVARIVPLTRRRQWLPAAEVIGELMRLGPDTTNLSEELPETLTQTT
DDVSW

Download         Length: 258 bp

>AT36379 NZ_AP022615:c1297346-1297089 [Mycobacterium heidelbergense]
ATGGCTGCTACGATACCCGCCCGCGATCTCCGTAACCGCACCGCTGAGGTGCTGCGGCGAGTTGCGGCAGGCGAGGAGAT
CGAGGTGCTCAAGGACAATCGTCCTGTGGCGCGCATAGTCCCACTCACACGGCGCCGCCAATGGCTACCGGCAGCGGAGG
TAATCGGCGAACTCATGCGCCTGGGTCCCGATACCACCAACCTCAGCGAGGAACTGCCGGAGACGCTGACACAGACCACG
GACGACGTGTCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References