Detailed information of TA system TA036378

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1127933..1128558
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS05300
• Protein ID: WP_083075066.1
• Coordinates: 1128148..1128558 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS05295
• Protein ID: WP_083075068.1
• Coordinates: 1127933..1128157 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS05260	1123444..1123740	+	297	WP_083075079.1	WhiB family transcriptional regulator	-
G6N25_RS05265	1123941..1124354	+	414	WP_083075119.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G6N25_RS05270	1124351..1124659	+	309	WP_083075077.1	XRE family transcriptional regulator	-
G6N25_RS05275	1124648..1125862	-	1215	WP_083075075.1	cytochrome P450	-
G6N25_RS05280	1126026..1126487	-	462	WP_142272723.1	hypothetical protein	-
G6N25_RS05285	1127242..1127493	-	252	WP_083075072.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G6N25_RS05290	1127490..1127762	-	273	WP_083075070.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
G6N25_RS05295	1127933..1128157	+	225	WP_083075068.1	hypothetical protein	Antitoxin
G6N25_RS05300	1128148..1128558	+	411	WP_083075066.1	PIN domain nuclease	Toxin
G6N25_RS05305	1128751..1130376	-	1626	WP_083075064.1	chaperonin GroEL	-
G6N25_RS05310	1130460..1130762	-	303	WP_003873391.1	co-chaperone GroES	-
G6N25_RS05315	1131067..1132098	-	1032	WP_083075062.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD	-
G6N25_RS05320	1132095..1132562	-	468	WP_083075060.1	ribosomal protein S18-alanine N-acetyltransferase	-
G6N25_RS05325	1132559..1133179	-	621	WP_083075058.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (21-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14995.32 Da
• Isoelectric Point: 4.7160

>T36378 WP_083075066.1 NZ_AP022615:1128148-1128558 [Mycobacterium heidelbergense]
VAVTSWLIDKSAYTRLAASIDAQMWVDRIERGLVRISTITRLEIAYSFRSAVQAREESASPPLTLMPLEYLTPAAEERAI
AVQLLLADRGQHRAPSIPDLLIAATAEVANLTVLALDKDFDLIADITGQPIERLRL

Nucleotide

• Length: 411 bp

>T36378 NZ_AP022615:1128148-1128558 [Mycobacterium heidelbergense]
GTGGCGGTAACCTCGTGGCTCATCGACAAGTCGGCCTACACCCGCCTTGCAGCATCCATCGATGCCCAGATGTGGGTAGA
TCGAATCGAACGCGGTCTGGTTCGGATCAGCACCATCACACGACTTGAAATTGCCTACTCGTTTCGGAGTGCTGTGCAAG
CGCGCGAAGAATCGGCCTCACCGCCGCTTACTTTGATGCCCTTGGAGTATCTGACACCTGCGGCCGAGGAGCGTGCGATC
GCGGTTCAATTGCTCCTCGCCGACCGTGGCCAGCACCGTGCACCATCGATTCCTGATCTGCTGATTGCGGCCACCGCCGA
GGTCGCTAATCTGACAGTCTTGGCTCTGGACAAGGACTTTGATCTGATAGCAGATATCACCGGGCAACCGATCGAGCGCC
TACGTTTATGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8136.98 Da
• Isoelectric Point: 4.6050

>AT36378 WP_083075068.1 NZ_AP022615:1127933-1128157 [Mycobacterium heidelbergense]
MADVLIRGLSDAAVARIDADAASQGVSRNEYLRRRFESERSAGPDSKLTVEDLRRAAEAAKDLDDGQVMESAWR

Nucleotide

• Length: 225 bp

>AT36378 NZ_AP022615:1127933-1128157 [Mycobacterium heidelbergense]
ATGGCAGATGTACTCATTCGGGGATTGTCCGATGCCGCTGTGGCCCGCATCGACGCCGACGCGGCTTCCCAGGGGGTGTC
GCGCAATGAATACCTTCGCCGCAGATTTGAGTCTGAACGATCCGCCGGTCCGGACAGCAAACTCACCGTCGAGGATCTCC
GTCGGGCTGCCGAGGCCGCCAAGGATCTTGACGATGGACAGGTAATGGAGTCTGCGTGGCGGTAA