Detailed information of TA system TA036376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 1100613..1101280
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N25_RS05160
• Protein ID: WP_083075108.1
• Coordinates: 1100613..1101005 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N25_RS05165
• Protein ID: WP_083075106.1
• Coordinates: 1101005..1101280 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS05150	1095934..1097097	+	1164	WP_083077372.1	trehalose-phosphatase	-
G6N25_RS05155	1097218..1100495	+	3278	Protein_1024	PE family protein	-
G6N25_RS05160	1100613..1101005	-	393	WP_083075108.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N25_RS05165	1101005..1101280	-	276	WP_083075106.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N25_RS05170	1101310..1102182	-	873	WP_083075104.1	MaoC family dehydratase	-
G6N25_RS05175	1102278..1102991	+	714	WP_083075102.1	histidine phosphatase family protein	-
G6N25_RS05180	1103034..1105034	+	2001	WP_083075100.1	SDR family oxidoreductase	-
G6N25_RS05185	1105163..1106118	+	956	Protein_1030	nucleoside hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-41)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14268.57 Da
• Isoelectric Point: 10.5032

>T36376 WP_083075108.1 NZ_AP022615:c1101005-1100613 [Mycobacterium heidelbergense]
MAAIYLDSSAIVKLAVREPESDALRRYLRTHRPRVSSALARTEVMRALLRQGESARKAGRRALAGLDLLRLDNRVLDLAG
GLLPFDLRSLDAIHLATAQRLGADLGRLCTYDDRMRDAAEALGMTVIALS

Nucleotide

• Length: 393 bp

>T36376 NZ_AP022615:c1101005-1100613 [Mycobacterium heidelbergense]
ATGGCGGCCATTTATCTCGACTCGTCCGCCATCGTCAAACTCGCGGTTCGTGAGCCGGAGTCGGACGCGCTGCGTCGGTA
CCTTCGCACCCACCGGCCCCGGGTGTCGAGCGCCCTGGCCCGGACGGAGGTCATGCGGGCTTTGCTGCGTCAGGGTGAAT
CAGCCCGGAAGGCCGGACGCCGGGCGCTGGCCGGCCTCGACCTGCTTCGCCTCGACAACCGGGTGCTCGATCTTGCCGGC
GGGCTGCTGCCGTTCGACCTGCGCAGCCTCGATGCGATTCACCTGGCGACAGCGCAGCGGCTCGGCGCCGATCTTGGCCG
GCTGTGTACCTACGACGACCGCATGCGCGACGCCGCCGAGGCGTTGGGCATGACGGTGATCGCCCTGTCCTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10036.39 Da
• Isoelectric Point: 4.4290

>AT36376 WP_083075106.1 NZ_AP022615:c1101280-1101005 [Mycobacterium heidelbergense]
MTAVGVRELRQRASELLRRVEAGETIEITDRGRPVALLSPMPEAGPYGQMLASGEIQRATVDFDDLPDPIDLEAGVELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT36376 NZ_AP022615:c1101280-1101005 [Mycobacterium heidelbergense]
ATGACTGCGGTGGGCGTGCGCGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGCCGCGTCGAGGCCGGAGAGACGATCGA
GATCACCGACCGCGGTCGGCCCGTCGCCCTTCTTTCGCCGATGCCGGAAGCGGGCCCTTACGGGCAGATGCTTGCAAGCG
GCGAAATACAGCGTGCCACAGTCGATTTCGATGACCTCCCCGATCCGATCGACCTCGAAGCGGGCGTCGAATTGCCGTCC
GTGACACTTGCCCGTCTGCGTGAGCATGAGCGTTGA