Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 832523..833112 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag G6N25_RS03950 Protein ID WP_083073807.1
Coordinates 832523..832855 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag G6N25_RS03955 Protein ID WP_083073806.1
Coordinates 832855..833112 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N25_RS03930 827939..828754 - 816 WP_179961699.1 FAD/NAD(P)-binding protein -
G6N25_RS03935 828765..829889 - 1125 WP_083073907.1 4Fe-4S dicluster domain-containing protein -
G6N25_RS03940 829940..830932 - 993 WP_083073809.1 NAD(P)H nitroreductase -
G6N25_RS03945 831050..832225 - 1176 WP_083073808.1 cation:proton antiporter -
G6N25_RS03950 832523..832855 - 333 WP_083073807.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N25_RS03955 832855..833112 - 258 WP_083073806.1 antitoxin Antitoxin
G6N25_RS03960 833287..833538 + 252 WP_083073805.1 helix-turn-helix domain-containing protein -
G6N25_RS03965 833535..834905 + 1371 WP_083073804.1 HipA domain-containing protein -
G6N25_RS03970 834987..835304 + 318 WP_083073803.1 hypothetical protein -
G6N25_RS03975 835301..836638 + 1338 WP_083073802.1 helicase-associated domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11750.50 Da        Isoelectric Point: 10.7596

>T36375 WP_083073807.1 NZ_AP022615:c832855-832523 [Mycobacterium heidelbergense]
IERGEIYIVSLDPTSGHEQRGTRPVLIVSPAAFNRLTKTPVVLPITRGGNFARTAGFAVSLADAGTRTTGVVRCDQPRAI
DIGSRDGRRVERVPPAVLGEVLAKLATVFE

Download         Length: 333 bp

>T36375 NZ_AP022615:c832855-832523 [Mycobacterium heidelbergense]
ATTGAGCGCGGCGAAATCTACATTGTTTCGCTTGATCCAACATCGGGCCATGAGCAGCGTGGCACGCGCCCGGTGTTGAT
CGTGTCGCCAGCCGCATTTAATCGTCTGACGAAAACGCCGGTGGTGCTACCGATAACGCGCGGCGGAAACTTTGCCCGTA
CAGCGGGCTTCGCGGTATCGCTGGCAGATGCGGGCACCCGCACGACCGGCGTGGTTCGCTGCGATCAGCCACGCGCAATC
GATATTGGCTCGCGTGACGGCCGCAGAGTCGAACGTGTGCCGCCCGCGGTCTTGGGCGAAGTACTGGCCAAGCTTGCCAC
TGTCTTTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9141.51 Da        Isoelectric Point: 4.3707

>AT36375 WP_083073806.1 NZ_AP022615:c833112-832855 [Mycobacterium heidelbergense]
VYTTKLRKVGGSVMLAIPPAFLDVLRLHAGAAVALSVDEGQLVVEPQVRPRYTLDELLAQCDASADPTVEDREWLDGKPV
GGELL

Download         Length: 258 bp

>AT36375 NZ_AP022615:c833112-832855 [Mycobacterium heidelbergense]
GTGTACACAACGAAGCTTCGCAAAGTCGGCGGTTCGGTGATGCTGGCGATACCTCCCGCGTTCCTCGACGTACTTCGCCT
TCACGCTGGGGCAGCGGTCGCCCTGTCGGTCGACGAGGGCCAGCTGGTTGTCGAACCGCAGGTGCGCCCTCGCTACACGC
TGGATGAACTGCTGGCTCAGTGTGACGCCTCAGCCGACCCCACGGTTGAAGATCGGGAATGGCTCGATGGCAAACCGGTC
GGCGGTGAGTTGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References