Detailed information of TA system TA036374

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 368050..368598
• Replicon: chromosome
• Accession: NZ_AP022615
• Organism: Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: G6N25_RS01830
• Protein ID: WP_083072814.1
• Coordinates: 368335..368598 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: G6N25_RS01825
• Protein ID: WP_083072812.1
• Coordinates: 368050..368331 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N25_RS01810	364247..365104	-	858	WP_083072808.1	type I methionyl aminopeptidase	-
G6N25_RS01815	365381..365704	-	324	Protein_358	hypothetical protein	-
G6N25_RS01820	365935..367749	-	1815	WP_083072810.1	penicillin-binding protein 2	-
G6N25_RS01825	368050..368331	+	282	WP_083072812.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N25_RS01830	368335..368598	+	264	WP_083072814.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N25_RS01835	368719..369573	-	855	WP_083072816.1	GNAT family N-acetyltransferase	-
G6N25_RS01840	369628..370788	-	1161	WP_083072817.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
G6N25_RS01845	370838..372058	-	1221	WP_083072819.1	M50 family metallopeptidase	-
G6N25_RS01850	372055..373230	-	1176	WP_083072821.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-
G6N25_RS01855	373315..373569	+	255	WP_071510275.1	DUF2631 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10294.88 Da
• Isoelectric Point: 12.0685

>T36374 WP_083072814.1 NZ_AP022615:368335-368598 [Mycobacterium heidelbergense]
VPHAVRFTATARRDLHKLPPRVRSAVVEFAFGDLSREPRRVGKPLRRELTGAFSARRGPYRILYRIDDERTTVWILRVDH
RADVYRR

Nucleotide

• Length: 264 bp

>T36374 NZ_AP022615:368335-368598 [Mycobacterium heidelbergense]
GTGCCTCACGCCGTCCGATTCACTGCAACAGCGCGCCGAGACCTGCATAAGCTGCCACCGCGAGTCCGCTCCGCGGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGTGAACCTCGTCGGGTGGGCAAGCCGCTTCGGCGCGAGTTGACCGGCGCGTTCA
GCGCACGTCGCGGGCCGTACCGCATCCTGTACCGCATCGACGACGAACGCACGACCGTATGGATCCTTCGCGTTGATCAC
CGCGCCGATGTCTACCGCCGATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10142.43 Da
• Isoelectric Point: 4.2584

>AT36374 WP_083072812.1 NZ_AP022615:368050-368331 [Mycobacterium heidelbergense]
MRTLPISKVKDKLNEFVDAVALTQDQITITKNGAPAAVLIGADEWESLQETLYWLAQPGIKESLAEADADIAAGRGYGED
EIRAEFGLPRRPS

Nucleotide

• Length: 282 bp

>AT36374 NZ_AP022615:368050-368331 [Mycobacterium heidelbergense]
ATGCGGACACTGCCGATCTCGAAGGTCAAGGACAAGCTCAATGAGTTCGTCGACGCTGTCGCGTTGACGCAGGACCAGAT
CACCATCACCAAGAACGGTGCGCCGGCGGCCGTCCTGATCGGCGCCGATGAGTGGGAATCGTTGCAGGAGACGCTGTATT
GGCTTGCACAACCGGGAATCAAGGAGTCGCTCGCCGAAGCCGACGCCGACATCGCGGCCGGCCGCGGCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCCTCCCGCGGCGCCCCAGCTAA