36373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 275448..276079 Replicon chromosome
Accession NZ_AP022615
Organism Mycobacterium heidelbergense strain JCM 14842

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N25_RS01365 Protein ID WP_083072714.1
Coordinates 275448..275846 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N25_RS01370 Protein ID WP_083072715.1
Coordinates 275843..276079 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N25_RS01345 271046..271918 + 873 WP_083072711.1 SAM-dependent methyltransferase -
G6N25_RS01350 271915..273600 - 1686 WP_083072712.1 ribonuclease J -
G6N25_RS01355 273608..274510 - 903 WP_083072713.1 4-hydroxy-tetrahydrodipicolinate synthase -
G6N25_RS01360 274655..275407 - 753 WP_083072875.1 FAD-dependent thymidylate synthase -
G6N25_RS01365 275448..275846 - 399 WP_083072714.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N25_RS01370 275843..276079 - 237 WP_083072715.1 antitoxin Antitoxin
G6N25_RS01375 276241..277290 - 1050 WP_083072716.1 restriction endonuclease subunit S -
G6N25_RS01380 277287..278687 - 1401 WP_083072717.1 type I restriction-modification system subunit M -
G6N25_RS01385 278684..279916 - 1233 WP_083072876.1 winged helix-turn-helix domain-containing protein -
G6N25_RS01390 279976..280677 - 702 WP_083072718.1 DivIVA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14438.52 Da        Isoelectric Point: 7.5187

>T36373 WP_083072714.1 NZ_AP022615:c275846-275448 [Mycobacterium heidelbergense]
VSDYVIDASALVLALVGKTDAADALRARLPEMRRHAPHLIDAEVGNVLRRHEQAGHIGTREADTALRVAGLLIDDRYPHV
GALARRAWSLRHNFSFYDALYVALASHLDVPLLTADTRLSRAPGLACRAELV

Download         Length: 399 bp

>T36373 NZ_AP022615:c275846-275448 [Mycobacterium heidelbergense]
GTGAGCGACTACGTTATCGATGCGTCCGCCCTCGTGCTGGCCTTGGTCGGCAAGACTGACGCCGCCGATGCACTCCGGGC
ACGGTTGCCCGAAATGCGGCGGCACGCACCGCATTTGATCGACGCTGAGGTCGGCAACGTGCTGCGCCGCCACGAGCAGG
CAGGACATATCGGCACCAGGGAAGCCGATACCGCGCTGCGCGTCGCCGGCTTGCTCATCGACGATCGCTATCCACACGTG
GGAGCGCTCGCCCGACGAGCGTGGAGCCTGCGGCACAACTTCAGTTTCTACGACGCGCTCTATGTGGCCCTGGCCAGTCA
CCTTGACGTTCCACTGCTGACCGCGGACACGCGCCTTAGCCGCGCACCGGGGCTGGCCTGCCGGGCCGAACTCGTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8652.72 Da        Isoelectric Point: 4.8279

>AT36373 WP_083072715.1 NZ_AP022615:c276079-275843 [Mycobacterium heidelbergense]
VATIQIREIPEDAYEVIRKRARVAGRSIQSYMRDWVIDFASRSTAEEALAAMEAAREESAKPGATTESILADLAADRR

Download         Length: 237 bp

>AT36373 NZ_AP022615:c276079-275843 [Mycobacterium heidelbergense]
GTGGCGACGATACAGATCCGGGAAATCCCCGAAGATGCGTACGAGGTGATCCGTAAGCGCGCCCGCGTCGCGGGGCGCTC
CATCCAGTCCTATATGCGTGATTGGGTGATCGACTTCGCGAGCCGGTCCACTGCGGAAGAGGCGTTGGCGGCCATGGAGG
CCGCGCGTGAGGAAAGCGCCAAACCGGGGGCGACGACGGAATCCATCCTCGCGGATCTGGCCGCAGACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References