Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5499134..5499788 Replicon chromosome
Accession NZ_AP022614
Organism Mycobacterium parmense strain JCM 14742

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N48_RS25555 Protein ID WP_085270071.1
Coordinates 5499327..5499788 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N48_RS25550 Protein ID WP_085270072.1
Coordinates 5499134..5499322 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N48_RS25540 5495110..5496693 + 1584 WP_085270074.1 serine hydrolase -
G6N48_RS25545 5496690..5499065 + 2376 WP_085270073.1 HAD-IC family P-type ATPase -
G6N48_RS25550 5499134..5499322 + 189 WP_085270072.1 antitoxin Antitoxin
G6N48_RS25555 5499327..5499788 + 462 WP_085270071.1 SRPBCC family protein Toxin
G6N48_RS25560 5499822..5500256 + 435 WP_085270070.1 hypothetical protein -
G6N48_RS25565 5500261..5500749 - 489 WP_085270141.1 VOC family protein -
G6N48_RS25570 5500749..5502281 - 1533 WP_085270069.1 carotenoid oxygenase family protein -
G6N48_RS25575 5502284..5503510 - 1227 WP_085270068.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16787.50 Da        Isoelectric Point: 10.0951

>T36372 WP_085270071.1 NZ_AP022614:5499327-5499788 [Mycobacterium parmense]
MAKLSGSIDVPLPPETAWKHASDLSRFKEWLTIHRVWRSKLPDDIDKGTVVESIVEVKGMYNRIKWTVVRYKPPEGMTLN
GEGVGGVKVKLMAKIQPKEQGSVVAFDVHLGGPALFGPIGMIVAAALRSDIDASLQNFVTVFTRPDPATNGHR

Download         Length: 462 bp

>T36372 NZ_AP022614:5499327-5499788 [Mycobacterium parmense]
ATGGCCAAACTCTCCGGATCGATCGACGTCCCGCTGCCTCCCGAGACCGCGTGGAAGCACGCGTCGGACCTGTCCCGTTT
CAAGGAATGGCTGACCATTCACCGCGTGTGGCGCAGCAAGTTGCCCGACGACATCGACAAGGGCACGGTTGTCGAGTCCA
TCGTCGAGGTGAAGGGCATGTACAACCGGATCAAATGGACCGTGGTGCGCTACAAGCCGCCGGAAGGCATGACGCTCAAC
GGAGAGGGCGTCGGCGGTGTGAAGGTCAAGCTGATGGCCAAGATTCAGCCCAAGGAACAGGGGTCGGTCGTCGCGTTCGA
TGTCCACCTGGGCGGTCCGGCGCTGTTCGGACCGATCGGCATGATCGTCGCCGCCGCGCTGCGAAGCGACATCGACGCGT
CCCTGCAGAACTTCGTCACGGTGTTCACCAGGCCCGATCCGGCCACGAACGGACACCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6644.36 Da        Isoelectric Point: 4.7066

>AT36372 WP_085270072.1 NZ_AP022614:5499134-5499322 [Mycobacterium parmense]
MGFLDKAKDLLSQNADKVEMAIDKAGEFVDDKTQGKYSDTIHKVADEAKKAADSAAAGDQKN

Download         Length: 189 bp

>AT36372 NZ_AP022614:5499134-5499322 [Mycobacterium parmense]
ATGGGATTCTTGGACAAGGCGAAGGACCTGTTGTCGCAGAACGCCGACAAAGTCGAGATGGCGATCGATAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATTCACAAGGTGGCCGACGAGGCCAAGAAGGCTGCGGACT
CCGCCGCCGCGGGCGACCAGAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References