Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PHD(antitoxin)
Location 5293522..5294205 Replicon chromosome
Accession NZ_AP022614
Organism Mycobacterium parmense strain JCM 14742

Toxin (Protein)


Gene name vapC Uniprot ID D5PEA4
Locus tag G6N48_RS24490 Protein ID WP_007168487.1
Coordinates 5293522..5293929 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1XBB9
Locus tag G6N48_RS24495 Protein ID WP_033711258.1
Coordinates 5293933..5294205 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N48_RS27900 5288803..5289018 + 216 WP_158514285.1 hypothetical protein -
G6N48_RS27905 5288957..5289202 + 246 WP_080711236.1 hypothetical protein -
G6N48_RS24460 5289178..5289489 + 312 WP_075362207.1 transposase -
G6N48_RS24465 5289523..5290758 + 1236 WP_085272092.1 IS30 family transposase -
G6N48_RS24470 5290875..5291045 - 171 Protein_4846 carnitinyl-CoA dehydratase -
G6N48_RS24480 5292794..5293099 - 306 WP_007168485.1 hypothetical protein -
G6N48_RS24485 5293160..5293501 - 342 WP_007168486.1 hypothetical protein -
G6N48_RS24490 5293522..5293929 - 408 WP_007168487.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N48_RS24495 5293933..5294205 - 273 WP_033711258.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
G6N48_RS24500 5294695..5295930 - 1236 WP_042909891.1 IS256 family transposase -
G6N48_RS24505 5296572..5296757 + 186 WP_132160383.1 hypothetical protein -
G6N48_RS24510 5296831..5297247 - 417 WP_007168492.1 type II toxin-antitoxin system VapC family toxin -
G6N48_RS24515 5297244..5297495 - 252 WP_007168493.1 ribbon-helix-helix protein, CopG family -
G6N48_RS24525 5298297..5298692 + 396 WP_007168495.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4983878..5313587 329709
- flank IS/Tn - - 5294695..5295930 1235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14464.55 Da        Isoelectric Point: 4.6697

>T36371 WP_007168487.1 NZ_AP022614:c5293929-5293522 [Mycobacterium parmense]
VIYLDTSALVKLIRIEVESDALADWLDERTETRWITSALAEVELPRAIRAVAPNGLSAVPSVLARLDRFEIDQVIRATAA
AYPDPALRSLDAIHLATAQIAASTAPLTAMVAYDSRLSDAARALGITIVTPGRNS

Download         Length: 408 bp

>T36371 NZ_AP022614:c5293929-5293522 [Mycobacterium parmense]
GTGATCTACCTGGATACCTCGGCTCTGGTCAAGCTGATCCGGATCGAAGTCGAATCTGATGCTCTAGCTGACTGGCTCGA
TGAACGCACCGAAACACGTTGGATAACATCTGCCTTGGCTGAAGTGGAGCTCCCCAGAGCCATCCGCGCAGTCGCCCCAA
ATGGCTTATCTGCTGTCCCCTCTGTGCTGGCCAGACTGGATCGGTTCGAAATCGACCAGGTCATCCGCGCCACCGCGGCC
GCCTACCCCGATCCGGCGCTGCGCTCGCTCGATGCGATACACCTGGCCACCGCTCAAATCGCCGCATCCACAGCACCATT
GACCGCCATGGTCGCCTATGACAGTCGACTCAGCGACGCCGCCCGTGCCCTCGGGATAACGATTGTCACACCTGGAAGAA
ACTCATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9764.35 Da        Isoelectric Point: 8.7382

>AT36371 WP_033711258.1 NZ_AP022614:c5294205-5293933 [Mycobacterium parmense]
MSEVPLRMLNQETAKVLARVKRGEEITLTERGEVIARIIPATAGPLDALITAGRVQPATLAGPAPRPTVPMHDNLDAGAL
LQRLRAEERY

Download         Length: 273 bp

>AT36371 NZ_AP022614:c5294205-5293933 [Mycobacterium parmense]
ATGAGTGAAGTACCTCTCCGAATGCTCAACCAAGAGACGGCAAAGGTCTTGGCCCGCGTCAAGCGTGGCGAAGAGATCAC
GCTTACTGAGCGCGGGGAAGTCATCGCCCGAATAATCCCCGCTACCGCCGGCCCACTGGATGCGTTGATCACTGCCGGCA
GAGTGCAACCGGCGACGCTGGCCGGCCCAGCCCCGCGGCCGACCGTTCCGATGCACGACAATCTCGACGCCGGCGCGCTA
TTGCAACGTCTGCGCGCCGAGGAAAGGTATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XAJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XBB9

References