Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 5224165..5224832 Replicon chromosome
Accession NZ_AP022614
Organism Mycobacterium parmense strain JCM 14742

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag G6N48_RS24115 Protein ID WP_007168407.1
Coordinates 5224440..5224832 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag G6N48_RS24110 Protein ID WP_007168406.1
Coordinates 5224165..5224440 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N48_RS27970 5219676..5220002 - 327 WP_033711234.1 hypothetical protein -
G6N48_RS24080 5219992..5220225 - 234 Protein_4769 transposase -
G6N48_RS24085 5220243..5221447 - 1205 Protein_4770 ISL3 family transposase -
G6N48_RS24090 5221586..5222218 - 633 Protein_4771 DDE-type integrase/transposase/recombinase -
G6N48_RS24095 5222212..5222301 - 90 Protein_4772 SDR family oxidoreductase -
G6N48_RS24100 5222354..5223057 - 704 Protein_4773 histidine phosphatase family protein -
G6N48_RS24105 5223140..5224012 + 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
G6N48_RS24110 5224165..5224440 + 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N48_RS24115 5224440..5224832 + 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N48_RS24120 5224980..5226139 - 1160 Protein_4777 trehalose-phosphatase -
G6N48_RS24125 5226181..5227519 - 1339 Protein_4778 DUF1298 domain-containing protein -
G6N48_RS24130 5227780..5227902 - 123 Protein_4779 IS1595 family transposase -
G6N48_RS24135 5228239..5229573 + 1335 Protein_4780 IS1182 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4983878..5313587 329709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T36370 WP_007168407.1 NZ_AP022614:5224440-5224832 [Mycobacterium parmense]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T36370 NZ_AP022614:5224440-5224832 [Mycobacterium parmense]
ATGGCGGCCATCTACCTGGACTCGTCCGCAATCGTCAAGCTTGCAGTTCGTGAGCCAGAGTCGGATGCGCTGCGTCGCTA
CCTTCGCACCCGGCTGCCGCGGGTGTCGAGTGCCCTTGCGCGGACGGAGGTCATGCGGGCTCTGCTCCACAAGGGTGAAT
CAGCCCGAAGAGCCGGACGCCGGGCGCTCGCGAGCCTAGACCTACTACGCATCGACAACCGATTGCTCGATCTTGCTGGT
GGGCTGCTGCCAATCGAGCTACGCACCCTCGATGCAATTCACCTGGCGACTGCCCAGCGGCTCGGCATGGATCTTGGCCG
GTTGTGCACTTACGACGACCGCATGCGCGACGCCGCCGAGGCGCTCGGCATGGCAGTGATTGCCCCGTCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT36370 WP_007168406.1 NZ_AP022614:5224165-5224440 [Mycobacterium parmense]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT36370 NZ_AP022614:5224165-5224440 [Mycobacterium parmense]
ATGTCTACGGTGGGCGTTCGTGAGCTGCGGCAGCGGGCCAGCGAACTCCTCCGTCGGGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGTGGTCGGCCTATCGCCCTTCTCTCGCCGATGCCGGAGGGCGGTCCGTACCAGCAGATGCTGGCAAGCG
GCGGGATCGAACGTGCGACGCTTGACTTTGATGACCTTCCCGAGCCGGTCCGACTCAAAACGGGTATCGAGCTGCCGTCC
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References