Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 5014296..5014825 Replicon chromosome
Accession NZ_AP022614
Organism Mycobacterium parmense strain JCM 14742

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag G6N48_RS23190 Protein ID WP_007172144.1
Coordinates 5014296..5014601 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID D5P1N8
Locus tag G6N48_RS23195 Protein ID WP_007172145.1
Coordinates 5014598..5014825 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N48_RS23160 5009374..5009514 + 141 WP_007172137.1 hypothetical protein -
G6N48_RS23165 5009511..5009897 + 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
G6N48_RS23170 5009967..5010644 + 678 WP_101930854.1 hypothetical protein -
G6N48_RS23175 5010644..5010976 + 333 WP_033717256.1 hypothetical protein -
G6N48_RS23180 5011264..5011551 + 288 WP_007172141.1 hypothetical protein -
G6N48_RS23185 5012989..5013924 + 936 WP_109413176.1 hypothetical protein -
G6N48_RS23190 5014296..5014601 - 306 WP_007172144.1 hypothetical protein Toxin
G6N48_RS23195 5014598..5014825 - 228 WP_007172145.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N48_RS23200 5015311..5016801 + 1491 WP_007172147.1 type VII secretion protein EccB -
G6N48_RS23205 5016815..5017930 + 1116 WP_131727273.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4983878..5313587 329709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T36369 WP_007172144.1 NZ_AP022614:c5014601-5014296 [Mycobacterium parmense]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T36369 NZ_AP022614:c5014601-5014296 [Mycobacterium parmense]
GTGATCACACCCGGAGACATCACGCCAGGCCGCGACACCAACCAGGAACTGTACGTTGTCGTACTATCTAACACGATTCA
CCTCGCAGCCGCCACCGGCCAGGTGATCATCTGCCCCTTCATTCCCGGTGAAATCCCCAGCAGCACAATGGCTATGATCG
TCACAGTGCTGCAACCCAAAGGGGTTGTCTTACCGGAGCTCATCCAGTGGCTTCCTGTCGCGGCCCTCGACCAACCCATC
GGCAATATCGGCGGCATCGCGCTCGCTGACACGACCACGACCGCCGTCACCGCGCTCATTTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8153.21 Da        Isoelectric Point: 5.0079

>AT36369 WP_007172145.1 NZ_AP022614:c5014825-5014598 [Mycobacterium parmense]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKVYQANRAAGL

Download         Length: 228 bp

>AT36369 NZ_AP022614:c5014825-5014598 [Mycobacterium parmense]
ATGGCGAAAGCCAAAGTGTCCGTAATGATTGAAGAGGCCGTGCTGGCGGCGGCCGATGCGGACGCCCAGGCGGCCGGGCT
GAATCGTTCAGAGATGATCGAACGAGCCCTGCACAACGAGCATCTCCGAATCTCGCTCGAGAACTACACAACACACACTG
TGCCAACGCTCGACATCGACGCCTACGCGGAGAAGGTCTATCAGGCGAACCGGGCCGCTGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XDJ0

References