Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5540046..5540734 Replicon chromosome
Accession NZ_AP022613
Organism Mycobacterium conspicuum strain JCM 14738

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N66_RS25515 Protein ID WP_085235757.1
Coordinates 5540297..5540734 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N66_RS25510 Protein ID WP_085235758.1
Coordinates 5540046..5540300 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N66_RS25490 5535543..5536349 + 807 WP_085235762.1 hypothetical protein -
G6N66_RS25495 5536330..5537142 - 813 WP_085235761.1 DUF3060 domain-containing protein -
G6N66_RS25500 5537176..5538453 - 1278 WP_085235760.1 serine hydrolase -
G6N66_RS25505 5538494..5539486 - 993 WP_085235759.1 ATP-binding cassette domain-containing protein -
G6N66_RS25510 5540046..5540300 + 255 WP_085235758.1 antitoxin Antitoxin
G6N66_RS25515 5540297..5540734 + 438 WP_085235757.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N66_RS25520 5540967..5541413 + 447 WP_139825487.1 MmpS family protein -
G6N66_RS25525 5541410..5544265 + 2856 WP_085235756.1 MMPL family transporter -
G6N66_RS25530 5544286..5544888 + 603 WP_085235800.1 TetR/AcrR family transcriptional regulator -
G6N66_RS25535 5545053..5545193 + 141 WP_085235755.1 tyrosine-type recombinase/integrase -
G6N66_RS25540 5545199..5545459 - 261 WP_085235754.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15450.52 Da        Isoelectric Point: 5.4489

>T36368 WP_085235757.1 NZ_AP022613:5540297-5540734 [Mycobacterium conspicuum]
MRIVDANVLLYAVNTAADHHETSRRWLDGALSGGDTVGLAWVPLLAFVKLTTRHGLFPSPLTADAAMAQVLDWCSAPGAV
IVTPTPRHGDVLSALLAQVGAGGNLVNDAHLAALAIEHRARIVSYDSDFGRFDGLRWETPDSLVD

Download         Length: 438 bp

>T36368 NZ_AP022613:5540297-5540734 [Mycobacterium conspicuum]
ATGAGAATCGTCGACGCCAATGTCCTGTTGTACGCCGTCAACACGGCCGCCGACCACCACGAGACCTCACGCCGCTGGCT
CGACGGTGCGCTGTCCGGCGGTGACACCGTCGGACTGGCCTGGGTGCCGCTACTCGCATTCGTGAAGTTGACGACTCGGC
ATGGGCTTTTCCCTTCGCCCCTGACTGCCGACGCGGCAATGGCTCAAGTACTCGACTGGTGTAGCGCACCAGGCGCCGTC
ATCGTGACGCCGACCCCGCGTCACGGCGACGTGCTGTCCGCGTTGCTGGCACAGGTCGGCGCGGGAGGAAATCTCGTCAA
CGACGCCCACCTTGCCGCCTTGGCGATCGAGCACCGCGCCCGAATAGTGAGTTACGACAGTGACTTTGGACGATTCGACG
GTCTGCGGTGGGAAACACCGGACTCACTGGTGGATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9791.25 Da        Isoelectric Point: 12.0046

>AT36368 WP_085235758.1 NZ_AP022613:5540046-5540300 [Mycobacterium conspicuum]
MRTTVTLDDDTLVVVRRLMRERRISFKQALNDAIRQGARQRRASTVFQTRTADLGVPSVKLDRALQLAGELEDEELIRRQ
RRRA

Download         Length: 255 bp

>AT36368 NZ_AP022613:5540046-5540300 [Mycobacterium conspicuum]
ATGCGCACCACGGTGACACTGGACGATGACACGCTCGTGGTTGTCCGGCGGCTGATGCGTGAACGCCGCATCTCGTTCAA
ACAGGCTCTCAATGACGCCATCCGGCAAGGCGCACGGCAGCGCCGGGCCAGTACGGTCTTCCAAACGCGCACAGCCGATT
TGGGTGTTCCGTCGGTCAAGCTGGACCGGGCGCTGCAGCTCGCCGGCGAACTCGAAGACGAAGAATTAATCCGGCGACAG
CGCCGCCGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References